The review of the literature is devoted to epidemiology, classification and diagnostic imaging of pathological vertebral fractures (PVF). Osteoporosis and tumor lesion are known as the most common causes of PVF. The development of treatment methods requires accurate differential diagnosis of PVF etiology with diagnostic imaging. MRI represents the highest accuracy in differential diagnosis of PVF.

Purpose. To estimate the relevance of surgical treatment of patients with metastatic bone disease.
Materials and methods. from april 2015 to april 2016, we have consulted 231 patients with metastatic bone disease.
Results. We performed 107 operations in 74 patients from which minimally invasive techniques performed in 53 (71%) patients. Spine stabilizing operations and bone resections conducted in 21 (29%) of patients.
Conclusion. The demand of orthopedic treatment in patients with metastatic bone disease is 35%. Without minimally invasive techniques, this value is 9%. There were no significant complications after performed surgeries in all groups. pain has decreased fully or partially in 66 (89%) of patients. neurologic status has improved in 8 of 12 (66%) of subjects. Increased ECOG and MSTS functional status was observed in 18 of 74 (24%) and 7 of 10 (70%) of patients respectively.

The paper presents experience of surgical treatment of 33 patients with tumors of sacroiliac joint. all patients underwent surgery without disturbing the pelvic ring. The mean age of patients was 39 years (18 to 72). histological type of the tumors were: chondrosarcoma – 12 (36,4%), aneurysmal bone cyst – 6 (18,2%), osteochondroma – 5 (15,1%), giant cell tumor – 4 (12,1%), osteoblastoma – 2 (6%), others – 3 (9%). Mean operative time was 150 minutes (60 to 300). The volume of intraoperative blood loss averaged 1500 ml (100 to 6000). Postoperative complications were observed in 4 (12%) patients. average follow-up was 53,4 months (6–132 months). recurrence were observed in three patients in the period from 3 to 34 months. The mean MSTS score at last available follow-up was 83% (66–100%).

Background. Еvaluation of stereotactic radiation therapy (SRT) in the treatment of primary and metastatic bone lesions.
Methods. We represent the results of bone treatment (both primary and metastatic bone tumors) in «Oncostop» clinic from 2013 up to 2015 – totally 74 cases, including 44 metastatic (61%) and 25 primary lesions (35%). all patients received Srt  using «Cyberknife-VSI».
Results. The median follow-up in metastatic and primary tumor groups was 14,5 and 15 months correspondingly. We found 9 cases of local recurrence, including 2 among 44 metastatic tumors (4,5%) and 7 – among 25 primary bone tumors (28%). Median recurrence-free interval in metastatic group was 4,5 months, in primary tumors group – 12 months. Among 9 recurrences, 8 patients received SRT after previous irradiation. The average irradiated volume among recurrences was 169,5 cc (max 410 cc). Three patients with recurrence received stereotactic reirradiation with good effect.
Conclusion. SRT is able to provide a long local disease and pain control among inoperable bone tumors (more than 12 months). The outcome of treatment depends on irradiated volume and sequence of methods. It is reasonable to use SRT in primary treatment of radioresistant disease, in case of recurrence repeated stereotactic irradiation is possible.

Background. To study a role of pathomorphosis as an index of the effectiveness of intra-arterial chemotherapy in non-epithelial malignancies of the maxilla, nasal cavity and paranasal sinuses.
Materials and methods. During the period 2000–2008 and in 2013–2015 48 patients with non-epithelial malignant tumors of the maxilla and the paranasal sinuses were treated. Patients depending on the method of treatment at the first stage were divided into 4 groups: 1) long intra-arterial chemotherapy with local UHF-hyperthermia and radiation therapy (10 patients); 2) long intra-arterial chemotherapy and radiation therapy (14 patients); 3) systemic chemotherapy and radiation therapy (12 patients); 4) radiation therapy with a subsequent operation (12 patients). After 3–4 weeks after completion of neoadjuvant treatment, the patients underwent surgery.
Results. A comparative study of the expression of the therapeutic pathomorphism in groups, it was found that the III–IV degree pathomorphosis in group 1 were detected in 4 (57%) patients in 2nd group – 5 (50%) in 3^d group – 4 (36%) and the 4^nd group – 2 (20%) patients. Analyzing the data by group, it shows that most pathomorphosisism stage III–IV was found in 1^st group, then in the 2^nd group of patients.
Conclusion. In patients who received neoadjuvant chemotherapy, a regional intraarterial direct morphological effect (degree pathomorphosisism) of treatment was greater than in patients who received systemic chemotherapy.

This article presents the first experience of using ultrasound extractor of bone cement in removing of broken plastic endoprosthetic stem after 14 months of implanting. This method allowed by saving potential bone for possible future re-replacement, to achieve a similar quality to the primary tumor endoprosthesis stem fixation. solving the problem of any kind of replacement complications is the search and development of unique, non-standard, but at the same time rational and easy implementation techniques. The present study shows the possibility of ultrasound extractor to remove not only the bone cement in difficult extractable stems, but if necessary any plastic endoprosthesis elements.

Despite therapeutic advances in metastatic melanoma, fundamental changes in the section of adjuvant therapy has not yet come. The problem of adjuvant therapy in cutaneous melanoma in Russia is of particular importance due to the large proportion of advanced forms of the disease in the patient population with the local and regional stages. To date, it is shown that recombinant interferon alpha-2a and alpha-2b (IFN alpha) are an effective drugs for adjuvant therapy melanoma. high-dose interferon alpha-2b (HDI) is the standard treatment in the Us in patients with IIB–III melanoma stages. In this article we consider the portability of hdI during adjuvant therapy in patients with high-risk melanoma in a specialized department.

We evaluated serum S-100B protein in 45 patients with melanoma and in 40 healthy donors as a control group. Results revealed elevation of S-100В in cases with primary tumors and cases with recurrent disease. Test sensitivity was 63%, specificity – 72,5%, accuracy – 67,4%. S-100B is primary diagnostic marker that may predict disease progression but further studies are needed.

Lymphedema – the consequence of surgical damage to the lymphatic vessels. This pathology is associated with lymph node and/or radiotherapy. selecting treatment methods lymphedema varies depending on the severity of edema and fibrosis of the affected limb. lymphovenous anastomosis is the most effective and long term solution for the treatment of lymphostasis limbs. The technique of vascularized transplantation of lymph nodes is to move the tissue containing the lymph nodes in the supply vessels, followed by the imposition of microsurgical anastomosis in the recipient area. This paper describes a clinical case of delayed reconstruction of the left breast TRAM-flap with simultaneous transfer of the inguinal lymph nodes in the axilla. The first evaluation of the effectiveness of the operation carried out 3 months after surgery, regression of lymphedema is about 29%. The use of modern methods of reconstructive surgery and high-tech equipment allows you to achieve both a good aesthetic results after surgical treatment of breast cancer, and significantly reduce lymphedema of the upper limbs.

Case report of patient with primary multiple melanomas in one anatomic area in different time frames and different pathologic characteristics is presented. Time intervals were 2 and 3 years between new lesions. Follow up was 4 year. Absence of distant metastasis during follow up period shows better prognosis in primary multiple melanoma comparing to recurrent disease cases.