Materials and methods. Monitoring and analysis of features of bone metastases clinical progress in 304 patients with breast, renal, colorectal and non-small cell lung cancer. Results. The research showed that bone metastases most frequently appear during the first clinical relapse (89-96% of all patients with bone metastases) with the exception of colorectal cancer (54%). Relation between bone metastases progress and disease stage has not been revealed. Metastatic spread varied from disseminated (breast cancer) to moderate (lung cancer) and minimal (renal and colorectal cancer). From 17% (colorectal cancer) to 38% (breast cancer) of patients had pathological bone fractures at the moment of bone metastasis identification. Pain syndrome, requiring treatment with narcotics, was strongest for patients with renal cancer (49,5%) and minimal for patients with breast cancer (5,4%). Possibility of dose decrease or recall of analgetics was highest for patients with breast cancer (77%) and lowest for patients with renal cancer (45,5%) and lung cancer (26,4%). Surgical interventions were done to cope with neurological disorders, clinical pain syndrome and as a radical treatment of the disease. Neurological disorders required surgical intervention mostly for patients with renal cancer (11,1%) and colorectal cancer (7,3%), while surgery for pain syndrome was most frequent for patients with renal cancer (9,1%). 21,1% of patients with renal cancer were operated to cure solitary bone metastases. Resume. Modern therapy of bone metastases helps to preserve satisfactory quality of life for the majority of patients. The role of bisphosphonates in bone metastases treatment (with the exception of breast cancer) is still not clearly defined.

Qbiective. To analyze and estimate the oncological and functional results of surgical treatment of patients with tumors of the upper chest wall Materials and methods. During the period from 2005 to 2011 17 patients, with tumors of the upper part of the chest wall with involvement of bone structures, were treated. Primary tumors of the ribs, sternum or clavicle were found in 8 (46,8%) cases, soft tissues tumors of the of the chest wall with invasion of adjacent bony structures in 5 (30%), metastasis of the chest wall was in 4 (23,2%) cases. Isolated involvement of bone structures diagnosed - in 7 (41%) cases, combined - in 10 (59%) cases. Involvement in the neoplastic process of the chest cavity was in 3 (17,4%) cases. Results. Excellent and good orthopedic and functional results were achieved in 14 patients (82%) and satisfactory in 3 (18%) patients. Progressive disease was noted in 4 (23,5%) cases after 3 to 12 months. Median follow-up of patients was 14,7 months. Died from disease progression 4 (23,5%) patients died from disease progression in the period from 10 to 34 months after the surgery. Conclusion. Our results indicate the need for selecting an active surgical approach in this category of patients. The vast majority of the operations in view of the tentative large deficiency of chest wall is not possible to manage without a reconstructive plastic surgery, which allows to restore the function of skeletal completely, and to prevent the development of cardio-respiratory disturbances and thus to achieve good functional and orthopedic outcome.

The aim of the study was to obtain experimental data on the specific antitumor activity of the thermochemotherapy (TCT), which combines local ultrasound hyperthermia and chemotherapy with cisplatin and doxorubicin. Material and methods. The experiments were performed on mice with murine intramuscular transplanted hematogenic metastatic tumors Lewis lung carcinoma LLC and melanoma B16 with average volume of 0,6-1,1 cm³. Local ultrasound hyperthermia (US-HT) was performed on the original ultrasonic device USDT-m with ultrasound of two frequencies (0,88 and 2,64 MHz) simultaneously with a maximum intensity of 2,5-3,0 W/cm² in the temperature range 41,5-43 °C. Ultrasonic treatment was carried out after systemic chemotherapy with cisplatin (CP) and doxorubicin (Dox). Results. It was shown that local ultrasound hyperthermia and chemotherapy with cisplatin and doxorubicin allows to reduce the size of the tumor in 3-3,5 times, depending on tumor size and dose of cytostatics, with a satisfactory tolerability of treatment. Conclusion. The obtained results suggest a clinical trial of the TCT method with usage of USDT-m promising for preoperative treatment of patients with soft tissue sarcoma in order to achieve operability through cytoreduction of tumor mass.

118 patients with locally advanced STS examined and treated in MRRC were analyzed. In group 1 were included 31 patients treated by only surgery (S). The group 2 consisted of 33 patients treated with preoperative chemo-radiotherapy (CRT) followed by S. The group 3 included 22 patients received preoperative thermo-chemo-radiotherapy (TCRT) and S. The group 4 consisted of 32 patients, who received preoperative TCRT and S with intraoperative radiation therapy (IORT). Preoperative TCRT increased number of patients with stage III & IV of tumor therapeutic pathomorphism. TCRT and IORT didn't increase an incidence of complications and allowed to perform an increase organ-saving operations. None of the patients in group with TCRT had local recurrence during 3-5 years. The locoregional-recurrence-free-survival (LRFS), metastasis-free survival and overall survival rates (73-100, 56-88, 68-95%) were higher in group with combined treatment compared to first group (30, 20,5, 29%) respectively.

Backgrounds: Explanation of physical bases of spectrophotometric intracutaneous analysis (siascopy) - a new noninvasive method of screening, prophylaxis and early diagnostic for melanoma and skin cancer for adult and children with burdened family history (cases of melanoma in family), I-fototype (red hair, freckles, green eyes), FAMM syndrome, and another risk factors is discussed. Introduction of this method to the clinical practice gives the possibility of dinamic control and early treatment options for the patients with melanoma of the skin.

The expression levels of MMP-1,-2,-9 has been investigated in 10 benign cartilaginous tumors (osteochondroma - 5, chondroma - 5) and 39 chondrosarcomas (classic central - 14, periosteal - 4, dedifferentiated - 7, secondary - 14). The matrix metalloproteinase expression was negative in all examined benign human cartilaginous bone tumors. Our study have shown significant positive expression of metalloproteinase in chondrosarcoma cells: MMP-1 in 84,6% of cases, MMP-2 in 73,7 % of cases, MMP-9 in 97,4% of cases with the expression levels from 10 to 60%. No correlation was found between MMP-1 levels and gender of the patient, size and grade of the tumor, but correlate with the age. Expression of MMP-1 was more prominent in central and dedifferentiated chondrosarcomas. The levels of MMP-1(+) are closely associated with 3 year free survival and 5 year overall survival rate. The MMP-1 expression suggested aggressive behavior of the tumor. MMP-2 expression in chondrosaromas did not reflect clinical features, histological grade and variations of the tumor, and did not show prognostic value. MMP-9 expression correlate with the grade and size of the tumor (T criteria). MMP-9 expression more than 40% highly correlate with poor prognosis, less than 40% express positive factor for the 3 year free survival. The size of the tumor T3 in combination with MMP-9 expression more than 40% was considered a risk factor for relapse within

Background. The goal of this study was to analyze significance of AGT expression as predictive marker of efficacy of Dacar bazine+Cisplatin+Nidran regimen in patients with metastatic skin melanoma Methods. 26 patients with metastatic skin melanoma were enrolled in the retrospective study. Immunohistochemical analysis of AGT expression was performed on paraffin-embedded tissue sections of primary tumor or available metastasis. Results. High AGT expression in tumor cells was associated with low efficacy of Dacarbazine+Cisplatin+Nidran regimen. Disease progression was observed in 85,7% patient with AGT-positive tumor and 29,4% - AGT-negative (р=0,023). There was a not significant difference of time without progression between two groups of patients. Conclusion. AGT expression could be potentially useful tool for predicting response of metastatic melanoma patients to Dacarbazine+Cisplatin+Nidran regimen.

Serum levels of interferon γ (IF-γ) in healthy donors and in patients with benign bone neoplasms were significantly high comparing to borderline and malignant bone tumors. No reliable distinguishes were found between serum levels of IF-α in patients with benign, borderline and malignant bone tumors. Invert correlation was shown between age and serum level of IF-α in healthy donors, on the contrary no correlations were observed between age and serum levels of IF-γ and of IF-α in patients with bone neoplasms. and also serum IF-γ and IF-α levels in patients with bone sarcomas are not dependant on the tumors histology and on the size of primary bone tumors. No correlations were found in the levels of IF-α and IF-γ in patients with localized and metastatic tumor processes. direct correlation was found between IF-α and IF-γ serum levels in patients with malignant bone tumors in condition of maximal IF-concentrations in blood serum and advanced tumors.

Metastasis of different kinds of sarcomas in the brain is really rare pathology. This article contains own clinical work material (2 patients with metastasis of osteosarcoma and 1 patient with metastasis of alveolar soft tissue sarcoma in the brain) with time estimation from detection of primary site to metastasis into the brain, outcome analysis of given multimodatily treatment to patients with brain metastasis of sarcomas, quality and life of patients that underwent surgery, neurovisualization data in postoperative period and duration of disease remission.

Case report of 48-year-old female with dumbbell neurogenic tumor of cervical spine with spread to upper thorax aperture. Patient complained on lower paraparesis and pain syndrome. First stage of treatment was decompression laminectomy with removal of intraspinal part of the tumor and posterior fusion. Second stage included lateral approach, removal of paravertebral edge resection of CVI-ThI vertebral bodies and anterior stabilization with a.vertebralis reconstruction.