Purpose. Improving the results of local treatment of patients with lung cancer metastasis to the spine. Materials and methods. We analyzed the data of 106 patients with metastatic spinal lesions of lung cancer, mean age 55.9 years. The immediate and long-term results of treatment were studied, the prediction factors for the disease were searched for and ranked. Results. One-year survival of patients with lung cancer was 68%, 2-year-old - 25%, 5-year-old - only 3%. The levels of overall survival were not significantly different in adenocarcinoma groups without mutations, small cell and squamous cell carcinomas, and also depending on the method of treatment used. An attempt to use the Tokuhashi, Tomita and Bauer scales in patients with metastases to the spine with an unfavorable cancer prognosis indicated that the use of these prognostic tools was low. It is shown that the most significant for the prognosis in patients with lung cancer with metastases in the spine are such factors as the tumor histological type, molecular genetic features of the tumor, number of lesions, tumor process extent, presence of metastases in the visceral zones, functional state of the patient and number of chemotherapy courses. Obviously, these factors should be taken into account when developing treatment tactics and further monitoring of these patients. Conclusion. Indications for surgical treatment of patients with spine metastases of lung cancer should be determined taking into account the neurological and orthopedic status, as well as the general condition of the patient. Surgical local treatment is advisable to conduct patients with a life expectancy of at least 3-4 months; its volume depends on the expected life expectancy, which can be determined on the basis of individual prognostic factors. For patients with extremely poor prognosis (3 months or less), palliative radiotherapy is indicated in mono regimen. In patients with conditionally favorable oncologic prognosis after surgical local treatment, postoperative radiotherapy has been shown to consolidate the effect.

The purpose of this work is to present in Russia a modern classification for various forms of soft tissue sarcoma. Also present possible genetic aberrations for all types of tumors.

Pathological fracture is a severe complication of metastatic lesions of the long bones. The development of this complication leads to a significant reduction of the quality of life, as well as the risk of progression of the oncological process, due to the impossibility of carrying out specific antitumor treatment. The surgical stage of treatment improves both functional and oncological results of treatment, apart from pain relief and mobilization. It also allows doctors to start antitumor treatment at the earliest possible date after surgery.

In 1947, McCance removed a tumor in a 15-year old girl who had experienced 2 years of bone and muscle pain, with weakness and skeletal deformity. The lesion consisted of a degenerative osteoid tissue with giant cells that were well vascularized [1]. At that time, McCance did not put together clinical manifestations and skeletal changes. Several months later the patient recovered from her symptoms. This case history is considered to be the first report of oncogenic osteomalacia. The first correlation of clinical symptoms, osteomalacia and tumor deccribed Prader in 1957 based on the case of giant cell granuloma of the rib [5]. Subsequently described lesions, although given a plethora of names, may be characterized as mostly vascular and mesenchуmal in nature [3]. It has been shown that mesenchymal tumors, associated with oncogenic osteomalacia overexpress fibroblast growth factor-23, a recently described protein capable of inhibiting renal tubular epithelial phosphate transport. This is now thought to be the mechanism underlying most cases of oncogenic osteomalacia [2, 7, 8].

One of the characteristics of pelvic Ewing’s sarcoma is its ability to spread to healthy pelvic bones. Pelvic Ewing’s sarcoma is generally a late diagnosis due to lack of pathognomonic signs and symptoms. The majority of diagnosed cases are advanced with big size of tumor spread to two or even three pelvic bones often with distant metastases. Most patients are treated with chemoradiotherapy: half of pelvis is exposed to radiation with total radiation dose of 55-60 Gy which leads to severe radiation injuries of soft tissues and pelvic bones. Radiation boost led to significant decrease of radiation injuries. Due to high frequency of lung metastases preventive wide-field radiation therapy is used although treatment with total radiation dose of 12 Gy didn’t lead to long-term result improvement. Increase to 20 Gy resulted in total absence of lung metastases which significantly improved long-term results, 10-year survival rate was 62.5%. In the paper we provide information of modern treatment methods and report clinical case.

The preclinical studies of the functional suitability (therapeutic potential) of a new radiopharmaceutical intended for radionuclide verterboplasty were performed. In experiments on laboratory animals after 6 hours after filling the bone defect, the proportion of radiopharmaceutical retained was 99.89% on average. After 72 hours, the agent remained at the injection site by almost 100%, the accumulation of the agent in non-target organs and tissues was on the baseline, indicating a complete fixation of radiopharmaceutical in bone cement. The condition of animals treated with radiopharmaceutical varied from almost complete failure to the full recovery of limbs activity (equivalent use of both limbs). This indicates not only a decrease in the severity of pain, but also a stabilization of the bone structure with impaired integrity. In the group of untreated animals, impaired function was not restored, at the autopsy, spontaneous fractures of the tibia bone were found in the area of the bone defect. In vitro studies showed a slowdown in the formation of monolayer cells of the mammary adenocarcinoma in the culture flasks of the monolayer and their death on the 2^nd day after the start of incubation in the presence of radiopharmaceutical. The results of the studies indicate the functional suitability of the developed.

This clinical case is presented the example of the combined treatment of squamous cell carcinoma of the skin that developed on the background of an extensive post-burn scar. This type of tumor is characterized by the higher risk of relapses and metastases. Follow up was 8 months.There is no signs of progression or recurrence of the disease during this period, signs.