The review of the literature is devoted to the classification, epidemiology, clinical presentation and radiological findings of fibrous dysplasia of the skeleton. fibrous dysplasia (FD) is a benign process of the skeleton that develops in childhood. The clinical presentation of FD is largely determined by the lesion localization and its extent in the skeleton. Small size fibrous dysplasia may be asymptomatic and revealed as an accidental finding. In some cases radiological presentation of FD is similar to benign bone tumors resulting in difficulties of the differential diagnosis of these processes.

Three patients underwent calcaneus bone resection and reconstruction of the defect with toracodorsal flap. Three patients underwent calcaneus bone resection with replacement of the defect with thoracodorsal flap. age of patients was 11 years, 20 years and 50 years. complications of surgical treatment were not observed. all patients 3 months after surgery can move without additional support. Thoracodorsal flap is the method of choice for reconstruction of extensive defects of the calcaneus.

The best method of reconstruction after resection of malignant tumors of the bone diaphysis is unknown. We present a retrospective review of 19 patients who underwent limb salvage using a bone diaphyseal endoprosthetic replacement following excision of a bone tumor. Complications included aseptic loosening in six patients, progression diseases in two and one local recurrence. Six patients required revision surgery. rates of complication and revision were high, but diaphyseal replacement following resection of bone tumors enables early return to function, additional adjuvant treatment and provides an alternative to other surgical options, without apparent compromise of patient survival.

Treatment of malignant bone tumors of pelvis at the present time is a difficult clinical task, and requires careful preoperative evaluation of patients and planning of surgical intervention. During surgery for tumors in the area of acetabulum and posterior half of pelvis with disruption of continuity of the pelvic ring is required reconstructive phase of the intervention. One of the options of reconstruction during surgery, is endoprosthesis replacement using a modular or individual implants.

The ability of malignant tumors to metastasize remains a major obstacle to curative treatment for cancer. If the tumor process is generalized, systemic therapy is necessary to benefit from surgery. numerous retrospective studies have demonstrated that surgical removal of metastases limited to the lungs may prolong survival of cancer patients. This article describes the state of treatment of pulmonary metastatic disease. Different surgical approaches including single-stage unilateral or bilateral surgery, lymph node dissection, and repeated surgical interventions are discussed. The treatment of pulmonary metastases from bone and soft tissue sarcomas is discussed separately.

Material of the research were the results of the survey of 37 patients with uterus leiomyosarcoma (LMS), who were treated and observed at federal state scientific institution «Russian Cancer Research Center them. Blokhin» in the period from 2012 to 2014. Sonographic signs of metastases and recurrent uterus LMS are mostly hypoechogenic – the same as the signs of primary tumor. Echographic diagnostics makes possible to detect the presence of a pathological process, its localization, structure and sizes of tumor, clarify the diagnosis.

Sarcomas include soft tissue to tumors with high vascularization where angiogenesis plays an important role in their development and metastasis. most soft tissue sarcomas have a complex genetic profile with multiple mutations or aberrations, which make it difficult for the treatment with kinase inhibitors. Pazopanib – multityrosine kinase inhibitor of angiogenesis, targeted to receptors VEGFR-1, -2 and -3, and receptor and PDGFR-A and -B, c-Kit, which can provide long-term stabilization and objective responses in sarcomas.
Objective. Aim of the study was to evaluate the efficacy and safety of pazopanib in treatment of patients with soft tissue sarcomas.
Materials and Methods. 42 patients with metastatic soft tissue sarcomas in age from 19 till 78 years old after one or more lines of chemotherapy were enrolled in the study. Pazopanib was used in a dose of 800 mg Po daily.
Results. Efficacy of pazopanib was evaluated in 40 patients: CR – none, PR – in 1 patient (2.5%), SD – in 30 patients (75%), PD – in 9 patients (22.5%). Thus, control of tumor growth (complete remission, partial remission, stabilization) was achieved in 77.5%. The median time to progression was 8.3 months. The median overall survival has not been reached. Toxicity was mild and durable and almost the same as were reported in previous worldwide studies.
Conclusions. Based on the data obtained in this study pazopanib can be used as the second or more line of therapy. In some clinical cases efficacy of pazopanib was reported in patients with rare chemoresistant subtypes of STS.

Nerve sheath tumors that involve the sacral canal are rare because of delayed presentation and are required combined posterior and anterior approach. 20 patients with presacral neurogenic tumors with involving the sacral canal were operated by combined approach. The offered techniques allow to achieve good oncological outcome; laparoscopic removal of anterior part of tumor improves functional results.

Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer that is often associated with Merkel cell polyomavirus (MCPyV) infection. MCPyV prevalence and its relationship with clinical features and prognosis in MCC remain unclear. The aim of the study was to investigate the frequency and pattern of the MCPyV expression in primary and metastatic tumors from patients with MCC and evaluate the role of MCPyV in prognosis of patients with MCC in russia.

The need for bone repair is one of the major concerns in bone defects, fracture healing, and reconstructive surgery. There are many approaches to bone tissue engineering. In this review we describe molecular and cellular processes of osteal tissue and implant interaction.

Benign fibro-osseous lesions (Bfol) of the craniofacial area are represented by a variety of pathologic processes that are characterized by pathologic ossifications and calcifications in association with a hypercellular fibroblastic marrow element. The concept of Bfol has evolved over the last several decades and now includes two major entities: fibrous dysplasia and ossifying fibroma. We have analyzed 28 cases of Bfols of the craniofacial area in children and adolescents.

Background. To study a role of long intra arterial chemotherapy in surgical treatment of patients with non-epithelial malignant tumors of the maxilla, cavity of a nose and the paranasal sinuses.
Methods. During the period 2000–2008 and in 2014 38 patients with non-epithelial malignant tumors of the maxilla and the paranasal sinuses were treated. Patients depending on a method of treatment at the first stage were divided into 4 groups:
1) long intra-arterial chemotherapy with local uhf-hyperthermia and radiation therapy (10 patients); 2) long intra-arterial chemotherapy and radiation therapy (13 patients); 3) systemic chemotherapy and radiation therapy (5 patients); 4) radiation therapy with a subsequent operation (9 patients).
Results. Surgical treatment at the second stage of complex treatment, was carried out in 31 (83,7%) out of 37 patients. Partial resection of the мaxilla, removal of the struck anatomical structure was done in 2 (6,4%) patients. maxilla resection was done in 14 (45,1%) patients. Extended maxilla resection was performed in 13 (41,9%) pts. maxilla resection with orbital exenteration was made in 1 (3,2%) case. ethmoid sinus resection was performed in 1 (3,2%) patients.
Conclusion. Thus, neoadjyuvantny intraarterial chemotherapy in the 1^st and 2^nd groups of patients, allowed to reduce the volume of surgeries than at sick 3^rd and 4^th groups, which received traditional methods of treatment.

Existing legal framework regulating the management of medical devices is analyzed. Legal problems that hinder the development of production of medical devices are identified. Those rules and regulations that require improvement are denoted, including rules of state registration of medical devices, suggested consideration of the procedure of registration of medical devices depending on the class of risk. Nomenclature of the classifier of medical devices, harmonized with the global medical device nomenclature (GMDN) is widely discussed together with the draft of federal law «Management of medical devices» and a number of normative legal acts in the field of medical devices contained in the agreement of eurasian economic union.