Acquired melanocytic nevi formally belong to the group of benign tumors, but they (Spitz/Reed nevi, dysplastic, combined and blue nevi) require special attention and constant medical supervision due to the high risk of malignancy. Management of acquired nevi with high risk of malignancy depends on the results of clinical and dermatoscopy examination.

Background. Optimization of diagnostics of embologenic venous thrombosis and prevention of venous thromboembolism in patients with malignant tumors of bone and soft tissue was the aim of this study.
Methods. 84 patients were examined with sarcomas of bone and soft tissue, that underwent surgical treatment. Patients of the main group (49 patients) received daily ultrasound examinations of the inferior vena cava, and iliac veins of the lower extremities. Patients in the control group (35 patients) ultrasound examinations were performed only in cases of clinical symptoms of venous thrombosis. The clinical manifestations of thrombosis have been studied in patients of both groups.
Results. The coincidence of the clinical manifestations of thrombosis and results of ultrasound diagnosis of thrombosis was 34% of cases. Ultrasonic studies of the dynamics conducted in patients of the main group, revealed embologenic asymptomatic venous thrombosis in 11 patients. Prevention of pulmonary embolism, based on the results of ultrasound, allowed to prevent the development of venous thromboembolism in patients of the main group.
Conclusion. Systematic ultrasound of inferior vena cava, and iliac veins of the lower extremities, performed during the special treatment of malignant tumors of bone and soft tissues, can detect embologenic thrombosis and contribute to the implementation of effective prevention of venous thromboembolism.

Injuries and diseases of the musculoskeletal system are the second most common cause of temporary disability of the population and the third leading cause of disability and death. An effective treatment of these patients is arthroplasty. Annually 500–1000 patients per 1 million people in the world need prosthetics. In modern traumatology and orthopedics there has been a tendency to personified arthroplasty. The use of titanium alloys for the manufacture of implants allow most fully realize the important benefits: the best biocompatibility, high corrosion resistance, low modulus, high specific strength and endurance.

This article presents literature review on metastatic endometrial stromal sarcoma (ESS). Ultrasonic characteristics of ESS metastasis in abdominal cavity, retroperitoneal area, pelvis and soft tissues are widely discussed. Several case reports of patients undergoing treatment in our clinic are presented and discussed.

Background. To estimate the effectiveness of locally advanced soft tissue sarcomas of the extremities using an isolated perfusion chemotherapy in conditions of hyperthermia.
Methods. We performed the treatment results analysis of 57 patients with extremity soft tissue sarcomas. Patients were divided into 2 groups: first – 21 patients who received treatment with an isolated limb regional perfusion (ILP), melphalan (10 mg/l for lower limbs, and 13 mg/L for upper limb); second (control group) – 36 patients were treated with conventional methods of mutilating surgery. During the ILP original methodology for monitoring of chemotherapy income levels in the systemic circulation was used.
Results. Patients undergoing ILP with locally advanced soft tissue sarcomas of the limbs can achieve overall 2year survival rate of 90,5% comparing to 75% in the control group. Local toxicity in most cases did not exceed grade I and II under Wieberdink scale. Systemic grade I–II by CTC scale toxicity was observed in only few cases.
Conclusion. ILP is a promising method for the treatment of soft tissue sarcomas, contributing to the reduction of the tumor and prevent recurrence of the disease, thus avoiding performing the amputation surgery.

Resection of tumors of the anterior abdominal wall often leaves significant tissue defect. Modern methods of reconstruction allow to restore the integrity of the abdominal wall. Excision of locally advanced lesions often leads to complex defects requiring layered closure that allows radical treatment of cancer avoiding such complications as a postoperative hernia, postoperative wound infection and necrosis of soft tissues. This article provides an overview of the prevalence of preoperative assessment of tumor process, defect analysis, surgical planning and the choice of optimal surgical technique for replacing a defect.

The article contains description of the clinical case of primary hyperparathyroidism and osteodystrophy due to parathyroid adenoma. Difficulties of the differential diagnosis of osteodystrophy in the setting of metabolic disorders and massive pseudotumor lesions in bones are discussed. Results of the complex cytological, radiographic and biochemical tests of the patient are also presented.