Aim. To investigate risk factors for the development of soft tissue sarcoma recurrence.
Materials and methods. We analyzed treatment results of 168 patients (86 men and 82 women, age – 22 to 85 years, average age was 41 years) with primary soft tissue sarcomas (STS) of extremities and trunk. All patients with STS underwent surgical treatment, mainly wide excisions and 17 amputations were performed. Local relapses developed 39 patients. Multifactor analysis was performed to evaluate combined influence of the selected risk factors on the occurrence of the relapse. A prognostic scoring scale has been developed to provides an integral assessment of the possibility of the relapse taking into account all analyzed factors.
Results. On the basis of own and published data, a number of risk factors were selected to calculate prognostic factors (PF), with a maximum PC amount of 56, a minimum of 26, and a scale of 82 points. On the basis of nomographs by Gubler E.V. (1973), the upper (14) and lower (–9) thresholds were selected, dividing the entire scale into 3 distribution zones of forecasts in accordance with the values of the PF. The analysis of 39 STS relapse cases showed that only in 2 (5%) patients the prognosis outcome with this scale was qualified as «unclear», in the remaining 37 cases relapses were confirmed. In 129 patients without tumor recurrence, the prognosis was assessed as «unclear» in 12 patients, in other cases the prognosis was correct.
Conclusion. The conducted study showed the effectiveness of the developed approach for the prediction of sarcoma recurrence. An algorithm of individualized approach of postoperative followup is proposed and its implementation in a daily practice allows early detection of early recurrence in STS patients.

The article describes one of the most controversial topics of oncology – radiation-induced tumors, in particular, sarcomas of the head and neck region.
Radiation therapy is one of the most important methods of treating malignant neoplasms in modern oncology as an independent variant (possibly in combination with chemotherapy) and as adjuvant treatment after the operation. however, with the improvement of the results of treatment of cancer patients, more attention is devote to the side effects and complications of radiotherapy. one of the most rare and late complications are radiation-induced tumors that develop in irradiated tissues after a certain latent period.

The article describes case of using 3 dimensional technologies in the creation pelvic tumor endoprosthesis. At the first stage, computer simulation of surgical intervention was created and design of prosthesis was done. The next stage, titanium prosthesis was manufactured by 3D-additive technology. four courses of neoadjuvant chemotherapy with adriamycin and cisplatin was given preoperatively. The 3D-patient specific pelvic prosthesis was implanted accordingly preoperative plan. The article contains also surgical procedure and early outcomes of treatment.

Among malignant tumors, tumor lesions of the skeleton are relatively rare. However, most often disease affects young people of active age. Skeletal tumors often lead to disability of the patient. Thus, bone tumors are not just purely medical problem, but also a social one. Research of effective treatment for this group of patients remains an urgent task among orthopedic oncology.

Background. To estimate the effectiveness of locally advanced soft tissue sarcomas in patients treated with local hyperthermia in combination with preoperative radiation therapy and intraoperative radiotherapy.
Methods. 111 patients with locally advanced STS were analyzed. In the study group 56 patients were included, they received гadiation therapy, local hyperthermia and intraoperative radiotherapy. In the control group 55 patients the treatment was carried out according the same scheme but without local hyperthermia.
Results. The locoregionalrecurrencefreesurvival (LRFS), metastasisfree survival and overall survival rates (87,5; 91,07; 100%) at 2 years were higher in a study group, comparing to control group (76,2; 81,82; 90,91%) respectivly. Local hyperthermia didn’t increase incidence of postoperative complications.
Conclusion. Local hyperthermia was shown to be a promising treatment method that enhances tumor sensitivity to radiation therapy, reducing recurrence incidence and improving oncology and social results.

Objective. To evaluate the proliferative activity of dermal fibroblast cultures in the presence of composite materials based on titanium silicides in in vitro conditions.
Materials and methods. To assess the proliferative activity of dermal fibroblasts by in vitro direct contact test, with the use of titanium silicide, titanium carbosilicide oxidized in vacuum and without vacuum, titanium VT00 (comparison group). The proliferation index, the doubling time and the number of culture doubling during the cultivation time were calculated.
Results. To assess the proliferative activity of dermal fibroblasts by in vitro direct contact test, with the use of titanium silicide, titanium carbosilicide oxidized in vacuum and without vacuum, titanium VT00 (comparison group). The proliferation index, the doubling time and the number of culture doubling during the cultivation time were calculated.
Сonclusion. Active cell proliferation testifies to the non-toxicity and biocompatibility of the investigated alloys.

The article presents the results of clinical-psychological studies of the effectiveness of phantom pain psychological correction method in cancer patients using progressive muscle relaxation in combination with music and color rendering. Data analysis on a scale VAS before and after the correction showed a significant reduction in phantom pain in patients: respectively from 73,9±9 to 58,9±7,9 points, on a scale Wong–Baker intensity of phantom pain significantly decreased from 7.7±1,1 to 5,7±1,1 points. Along with a reduction in phantom pain, all patients noted improvement in sleep, mood, increasing physical activity.

In modern oncological orthopedics, an active search for the most optimal concept for the design of the manufacture of artificial joints and fixation parts of endoprostheses of rare anatomical areas continues, and the development of techniques for performing operations. The functional capabilities of patients after segmental resection of the proximal and distal femur significantly outweigh the patients after total femoral bone replacement, even with extensive resection. The preservation of the muscular apparatus of the upper and middle part of the femur with diaphysis-preserving total endoprosthetics, minimizes the risks of hip joint luxation, it is important to achieve similar functional results with segmental resection of the femur.