Method checkpoints of intraarterial regional chemotherapy in the treatment of osteosarcoma of the extremities
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Abstract
Regional intra-arterial chemotherapy in the treatment of high grade osteosarcomas is used to decrease the tumor volume and increase the amount of limb salvage surgeries. Combined neoadjuvant chemotherapy including systemic and regional infusion also decreases the risk oflocal recurrence and metastasis. Using combined intra-arterial and intra-venal chemotherapy good pathologic response was achieved in 81% of patients with 23% of complete necrosis. 5- year survival of 68% was achieved in children. Local recurrences where observed in 8,7% comparing to 27/5% in the group withjust adjuvant chemo. 5- year RFS and PFS were 66,8 % and 46.5% respectively. Regional chemotherapy maybe recommended for routine use due to high efficacy and low percent of complications.
About the Authors
B. I. Dolgushin
N.N. Blokhin Russian Cancer Research Center, Russian Academy ofMedical Sciences
Russian Federation
Russian Federation
E. R. Virshke
N.N. Blokhin Russian Cancer Research Center, Russian Academy ofMedical Sciences
Russian Federation
Russian Federation
G. A. Kushinskiy
N.N. Blokhin Russian Cancer Research Center, Russian Academy ofMedical Sciences
Russian Federation
Russian Federation
G. N. Machak
N.N. Blokhin Russian Cancer Research Center, Russian Academy ofMedical Sciences
Russian Federation
Russian Federation
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For citations:
Dolgushin B.I., Virshke E.R., Kushinskiy G.A., Machak G.N. Method checkpoints of intraarterial regional chemotherapy in the treatment of osteosarcoma of the extremities. Bone and soft tissue sarcomas, tumors of the skin. 2010;(2):27-34. (In Russ.)
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ISSN 2219-4614 (Print)
ISSN 2782-3687 (Online)
ISSN 2782-3687 (Online)
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