Endoprosthetics is the basic method of treatment choice in children with bone tumor. Radical resection of damaged bone region in patients with immature bone skeleton leads to shortening of the treated limb. Expanding endoprosthesis is the optimal choice in the solution of this problem. The historical excursion of evolution of expanding endoprosthesis creation is presented.

Methods. We performed a prospective study incidence, risk factors and haemodynamic effects associated with bone cement implantation syndrome (BSIS) at 211 oncological patients undergoing cemented joint replacement: total hip (30), knee (141), ankle (6), femur (9), elbow (3), hemischoulder (22) arthroplasty. The anesthetic technique consisted of superficial general or spinal anesthesia with epidural or conductive analgesia. The cardiovascular changes were determined. Multivariate logistic regression analysis was conducted to determine which clinical variables were predictive of BCIS.
Results. The incidence of BCIS was 7.8% (11/141), 3.3% (1/30), 0% (0/22) among patients undergoing knee, hip and shoulder arthroplasty accordingly; intraoperative mortality was 0% (0/211). Independed patient-related risk factors have been implicated in the genesis of BCIS including old age, body mass index. There were three cases of BCIS during knee arthroplasty with inflated tourniquet.
Conclusion. The cardiovascular indicators during cemented period could significantly increase that means cardiovascular reserves preservation.

Examination data of CT with multiplanar reconstruction of 109 pathological vertebral fractures were studied. The sensitivity of the method and the negative predictive value was 100%. This indicates the high accuracy of CT with multiplanar reconstruction in determining the group with osteoporotic vertebral fractures. The specificity is lower and amounts 85–88%, indicating the limitations of this method in determining the group with pathologic fractures on the background of the tumor lesion.

Soft tissue sarcoma (STS) – a heterogeneous group of tumors, which includes about 50 subtypes. generally STS are located on the extremities. The aim of the study is to analyze the possibility of using of isolated regional perfusion of extremities in the treatment of soft tissue sarcomas. According to major studies, the percentage of responses after the ILP is 70%, while a complete response develops in 20% of cases. Despite numerous studies and their optimistic results, the problem of the treatment of locally common extremity soft tissue sarcomas has not been fully resolved. To increase the efficiency of the ILP with melphalan and its wider use in the practice of specialized clinics the basic parameters of its implementation must be clearlyworked out, a patient selection criteria for integrated and combined treatment with the use of the ILP must be clearly formed.

Background. Analysis of the structure of subsequent malignancies in a follow up group of patients after the treatment of skin cancer.
Methods. 2801 case reports of the patients with skin cancer.
Results. 2801 patients were actively followed during 32 years. among these persons were observed 740 subsequent neoplasms at various sites, mainly at skin, gastrointestinal system, lung, breast and prostate.
Conclusion. It is advisable to make adjustments to existing screening programs.

Dendritic cell vaccine therapy induces activation of antitumor immune response, which in some cases can cause tumor regression even in advanced melanoma patients. Vaccine therapy after surgical treatment for prevention of tumor recurrence may be more effective. In this trial we present results for clinical and immunological effectiveness of dendritic vaccine therapy of stage III–IV cutaneous melanoma after surgical treatment.

Objective – to improve functional and aesthetic results after microsurgical mandible reconstructions, using 3d-printing. This method was used at 4 patients with massive oral cavity malignant tumors. surgical tumor resection and simultaneous reconstruction, using fibula flap was performed. Yirtual three-dimensional models of the mandible and operation planning was performed using ct-scans. These models were printed in 1:1 scale with 3d-printer(fused deposition modeling – FDM) and plastic models were used during fibula shaping. The sterilization of the models was done in the formaline chamber. This method allowed to get better functional results and decrease the operation time. resection of the tumor, raising of the flap and shaping could be done simultaneously.

Background. To study quality of life in patients with osteosarcoma, chondrosarcoma, giant cell tumor and bone metastases.
Patients and methods. During the period 2012–2015 the data of psychological research in 119 patients with bone tumor were obtained. There were four groups depending on diagnosis: the group of patients with osteosarcoma (41 persons), patients with giant cell tumor (31 persons), the group of chondrosarcoma patients (30 persons) and patients with bone metastases (adenocarcinoma) (17 persons). The methods were: «SF-36 Health Status Survey», Quality of Life Questionnary-Core 30 of European Organization for Research and Treatment Cancer with module Bone Metastases 22, «prevalent emotional condition», «The type of relation to disease», «Coping strategies».
Results. patients with bone metastasis have lower quality of life compared to patients with primary bone tumors. Patients with primary bone tumors are inclined to increased anxiety, low emotional stability and response to disease according to the type «escape into work».
Conclusion. patients with bone metastases have lower quality of life in the parameters general health, pain and fatigue compared to patients with osteosarcoma, chondrosarcoma and giant cell tumor (p<0,05). This corresponds to objective physical state of these patients’ groups. Emotional status in patients with bone metastases was higher than in other groups (p<0,05). It is due to high level of compliance in these patients.