This study examined the results of surgical treatment of 29 patients with brain metastases of melanoma (25 patients), and sarcoma (4 patients), complicated with tumor hemorrhage. Based on the obtained clinical and morphological data, there are three types of tumor hemorrhage. The frequency of thromboembolic complications in this group of patients. Through this study the factors affecting the development of local recurrence on postoperative mortality and survival of patients after surgical treatment.

The bone resection with endoprosthetic replacement of large joints is the method of choice for tumors and tumor-like diseases of the bones. In more than 80% of cases of primary and metastatic bone tumors, with modern integrated treatment approach to conservative intervention in the amount of bone resection with endoprosthetic replacement. However, the frequency of endoprosthetic revision for the various complications ranges from 5 to 50% according to different sources. The difficulty of performing the endoprosthetic revision is often due to a lack of unmodified bone tissue, soft tissue, infection lodge of the endoprosthesis.

Breast cancer is the most frequent oncological disease among women. It has especial predisposition for the bone metastatic disease and in 70% of cases the metastases to the spinal column can be found. It is a vital importance problem, because it can lead to such complications, as pathological fractures, pain syndrome, neurological deficits because of the compression of the spinal cord by the bone fragments. These complications can result in invalidization.
On the basis of the statistical analysis group of 76 patients was evaluated for functional results and follow – up of different types of the local treatment of the breast cancer metastases to the spinal column.

The review presents the recent data on the different types of the local treatment of patients with advanced breast cancer with spinal metastases.

The review of the literature is devoted to the classification, epidemiology, clinical presentation and radiological findings of osteoid-osteoma. Osteoid-osteoma is a benign bone producing tumor, that develops in a young group of patients. Clinical presentation of osteoid-osteoma, in spite of it small sizes (not more than 2 cm), followed with a severe pain. Along with clinical symptoms CT examination reveals osteoid-osteoma with a high accuracy.

Surgical treatment of primary and metastatic tumors, localized in the pelvic ring, is one of the most complex and little-known sections of oncology. Current problem is the replacement of the bone defect after resection. Limb salvage surgery, in combination with chemotherapy and postoperative radiation therapy, have replaced the classical hemipelvectomy in the treatment of pelvic bone tumors. The high frequency of complications associated with infection and instability of the implant, shows the relevance of the further development of methods of surgical treatment of these patients. The development of medical technologies and surgical techniques helped improve oncological outcomes and reduce the incidence of complications when compared with the results of 10-year-old. The article presents a literature review of the problem.

Combined approach is a standard of treatment of Ewing sarcoma patients. Chemotherapy, radiotherapy, surgery and possible targeted therapy are the main steps of successful treatment. Evolution of chemotherapy is discussed in this literature review.

Radiographic correlation is an essential adjunct for the accurate diagnosis of orthopedic lesions, yet it is a skill neglected by pathologists. The purpose of this review is to demonstrate why per- forming this correlation is an essential part of the diagnostic process and not merely an interesting adjunct to the surgical pathology of orthopedic lesions. The relationships between x-rays and tissues are explored with an emphasis on bone and soft tissue composition and structure. in addition, the rudiments of complementary imaging studies and how to incorporate their data into diagnoses are examined.

In this article we showed successful experience of surgical treatment of massive recurrent chondrosarcoma of the 3th rib with infiltration of left lung and pericardium. Reconstruction of the combined defect was performed with latissimus dorsi flap, Gore-Tex mesh and STRATOS titanium plate. Good oncological and functional result shows the benefits of radical surgical treatment with proper reconstructive methods.

Presents a clinical case of observation of the patient with multiple primary tumors of the three localizations.