Preview

Bone and soft tissue sarcomas, tumors of the skin

Advanced search

Case report: role of multidisciplinary approach in a case of spine osteosarcoma with oligometastatic heart disease

https://doi.org/10.17650/2219-4614-2023-15-4-56-63

Abstract

Introduction. Primary spinal osteosarcoma and rare metastatic heart lesion are considered significant factors for poor prognosis. The available work indicates that combined treatment, including the radical surgery of heart solitary metastatic lesion, probably provides the best outcome.

Case report. Man, 27-year-old, with Th8 spinal osteosarcoma and solitary left atrial metastasis. From October 2019 to February 2020 5 cycles of chemotherapy (high doses of platinum and doxorubicin) were carried out with positive effect. Next steps were surgery: March 2020 – spondylectomy of the Th8 vertebra with combined stabilization; September 2020 – subtotal resection with plasty of the right atrium, tricuspid valve and prosthesis of the right coronary artery. Between the first and second surgery, 4 more same chemotherapy cycles were carried out. Currently, 24 months after completion of treatment, there are no signs of the disease.

Conclusion. The article presents a unique case of treatment of primary osteosarcoma and metastatic lesion of rare location. Multidisciplinary approach and combination treatment in specialized centers increase the probability of favorable outcome in such cases.

About the Authors

A. A. Tararykova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

Anastasia Alekseevna Tararykova

24 Kashirskoe Shosse, Moscow 115522



A. K. Valiev
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

24 Kashirskoe Shosse, Moscow 115522



P. V. Kononets
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

24 Kashirskoe Shosse, Moscow 115522



E. R. Charchyan
B.V. Petrovsky Russian Surgery Research Center
Russian Federation

2 Abrikosovsky Lane, Moscow 119991



R. M. Kabardaev
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

24 Kashirskoe Shosse, Moscow 115522



A. V. Fedorova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

24 Kashirskoe Shosse, Moscow 115522



G. S. Batyrova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

24 Kashirskoe Shosse, Moscow 115522



A. R. Shin
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

24 Kashirskoe Shosse, Moscow 115522



N. A. Kozlov
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

24 Kashirskoe Shosse, Moscow 115522



References

1. Katonis P., Datsis G., Karantanas A. et al. Spinal osteosarcoma. Clin Med Insights Oncol 2013;7:199–208. DOI: 10.4137/CMO.S10099

2. Bishop M.W., Chang Y.C., Krailo M.D. et al. Assessing the prognostic significance of histologic response in osteosarcoma: a comparison of outcomes on CCG-782 and INT0133-A report from the Children’s Oncology Group Bone Tumor Committee. Pediatr Blood Cancer 2016;63(10):1737–43. DOI: 10.1002/pbc.26034

3. SEER Preliminary Cancer Incidence Rate Estimates for 2017, and diagnosis years 2000 to 2017, SEER 18. Available by: https://seer.cancer.gov/statistics/preliminary-estimates/.

4. Malignant neoplasms in Russia in 2020 (morbidity and mortality). Ed. by A.D. Kaprin, V.V. Starinsky, A.O. Shakhzadova. P.A. Herzen Institute of Medical Research – branch of the Federal State Budgetary Institution “NMIC of Radiology” of the Ministry of Health of Russia, 2021. 252 p. (In Russ.).

5. Salah S., Ahmad R., Sultan I. et al. Osteosarcoma with metastasis at initial diagnosis: current outcomes and prognostic factors in the context of a comprehensive cancer center. Mol Clin Oncol 2014;2(5):811–6. DOI: 10.3892/mco.2014.325

6. Yedururi S., Morani A.C., Gladish G.W. et al. Cardiovascular involvement by osteosarcoma: an analysis of 20 patients. Pediatr Radiol 2016;46(1):21–33. DOI: 10.1007/s00247-015-3449-y

7. Hartemayer R., Kuo C., Kent P. Osteosarcoma metastases with direct cardiac invasion: a case report and review of the pediatric literature. J Pediatr Hematol Oncol 2017;39(3):188–93. DOI: 10.1097/MPH.0000000000000808

8. Maleki M., Mozaffari K., Givtaj N. et al. Metastatic osteosarcoma and heart: a rare involvement in an unusual cardiac location. Heart Asia 2013;5(1):120–1. DOI: 10.1136/heartasia-2013-010342

9. Grebenc M.L., Rosado de Christenson M.L., Burke A.P. et al. Primary cardiac and pericardial neoplasms: radiologic-pathologic correlation. Radiographics 2000;20(4):1073–103. DOI: 10.1148/radiographics.20.4.g00jl081073

10. Platonov M.A., Turner A.R., Mullen J.C. et al. Tumour on the tricuspid valve: metastatic osteosarcoma and the heart. Can J Cardiol 2005;21(1):63–7.

11. Kvashnin A.V., Sagatov I.E., Dosmailov N.S. et al. Our experience in surgical treatment of primary heart tumors. Vestnik hirurgii Kazahstana = Bulletin of Surgery of Kazakhstan 2017;2(51):45–50. (In Russ.).

12. Sokolskaya N.O., Kopylova N.S., Skripnik E.V. Surgical treatment of primary heart tumors. Klinicheskaya fiziologiya krovoobrashcheniya = Clinical Physiology of Circulation 2017;14(4):238–42. (In Russ.). DOI: 10.24022/1814-6910-2017-14-4-238242

13. Burke A., Virmani R. Tumors of the heart and great vessels. In: Atlas of tumor pathology. 3rd series, fasc 16. Washington, DC: Armed Forces Institute of Pathology, 1996.

14. Bussani R., De-Giorgio F., Abbate A., Silvestri F. Cardiac metastases. J Clin Pathol 2007;60(1):27–34. DOI: 10.1136/jcp.2005.035105

15. Hashimoto W., Hashizume K., Ariyoshi T. et al. Primary cardiac osteosarcoma with imaging that revealed no calcification. Gen Thorac Cardiovasc Surg 2011;59(3):184–6. DOI: 10.1007/s11748-010-0656-1

16. Seibert K.A., Rettenmier C.W., Waller B.F. et al. Osteogenic sarcoma metastatic to the heart. Am J Med 1982;73(1):136–41. DOI: 10.1016/0002-9343(82)90940-8


Review

For citations:


Tararykova A.A., Valiev A.K., Kononets P.V., Charchyan E.R., Kabardaev R.M., Fedorova A.V., Batyrova G.S., Shin A.R., Kozlov N.A. Case report: role of multidisciplinary approach in a case of spine osteosarcoma with oligometastatic heart disease. Bone and soft tissue sarcomas, tumors of the skin. 2023;15(4):56-63. (In Russ.) https://doi.org/10.17650/2219-4614-2023-15-4-56-63

Views: 312


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2219-4614 (Print)
ISSN 2782-3687 (Online)