Возможности применения таргетной терапии при лечении остеосаркомы у детей и подростков (литературный обзор)
Аннотация
Методы лечения остеосаркомы на протяжении последних двадцати лет практически не менялись. существуют пять основных препаратов (цисплатин, адриамицин, метотрексат, ифосфамид, этопозид), которые применялись в различных комбинациях и дозах. результаты выживаемости приблизительно одинаковые. У пациентов с локализованным вариантом остеосаркомы 5-летняя общая выживаемость 75%, 5-летняя бессобытийная выживаемость – 62%. У пациентов с метастатической остеосаркомой результаты намного хуже: 5-летняя общая выживаемость – 35%, 5-летняя бессобытийная выживаемость – 20%.
Актуальность данной темы обусловлена тем, что результаты лечения остеосаркомы остаются неудовлетворительными, и оптимальная терапевтическая стратегия неизвестна. В связи с чем разрабатываются новые программы, опираясь на опыт применения протоколов, существовавших ранее, с учетом молекулярно-биологических особенностей опухолевых клеток. Исследование различных клеточных сигнальных путей, опухолевого микроокружения открывает путь к применению совершенно новых классов лекарственных препаратов (мультикиназных ингибиторов и моноклональных антител), клеточной и цитокиновой терапии.
Об авторе
Э. Р. Сенжапова
НИИ ДОИГ ФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина»
Россия
Россия
г. Москва
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Рецензия
Для цитирования:
Сенжапова Э.Р. Возможности применения таргетной терапии при лечении остеосаркомы у детей и подростков (литературный обзор). Саркомы костей, мягких тканей и опухоли кожи. 2014;(2):34-44.
For citation:
Senzhapova E.R. Possibility of targeted therapy of osteosarcoma in children and adolescents (literature review). Bone and soft tissue sarcomas, tumors of the skin. 2014;(2):34-44. (In Russ.)
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