О роли и возможностях лучевой терапии в лечении мягкотканных сарком
Аннотация
Постулат о радиорезистентности сарком существует уже несколько десятилетий. но современные представления о гетерогенности этой группы опухолей позволяют усомниться в его абсолютности. Лучевая терапия традиционно применялась на послеоперационном этапе лечения для улучшения показателей локального контроля, практика адъювантного облучения после радикального удаления сарком размером более 5 см в диаметре и особенно после R1-резекции является стандартной в настоящее время и рекомендована многими известными онкологическими центрами. Однако и предоперационное облучение сарком имеет явные теоретические преимущества, в ряде случаев подкрепленные экспериментальными и клиническими данными. в настоящее время наиболее перспективными направлениями в радиотерапии мягкотканных сарком признаны следующие: комбинация с химиопрепаратами и таргетными агентами; современные технологии облучения: IMRT, интраоперационная лучевая терапия, брахитерапия; применение альтернативных видов излучения: протонная, нейтронная лучевая терапия и облучение тяжелыми ионами; гипертермия.
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Рецензия
Для цитирования:
Деньгина Н.В. О роли и возможностях лучевой терапии в лечении мягкотканных сарком. Саркомы костей, мягких тканей и опухоли кожи. 2015;(4):52-62.
For citation:
Dengina N.V. Implications and opportunities for radiotherapy in soft tissue sarcomas treatment. Bone and soft tissue sarcomas, tumors of the skin. 2015;(4):52-62. (In Russ.)
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