Chemoperfusion as a method of choice in sarcomas treatment

G. I. Gafton; U. V. Semiletova; K. U. Senchik; A. M. Belyaev; I. G. Gafton

Chemoperfusion as a method of choice in sarcomas treatment

G. I. Gafton, U. V. Semiletova, K. U. Senchik, A. M. Belyaev, I. G. Gafton

Full Text:

PDF (Rus) |

Generate QR code

Abstract

Increased incidence of melanoma and soft tissue sarcomas of the extremities is observed nowadays. High probability of developing locally advanced forms of melanoma and soft tissue sarcomas of extremities lead to the use of combined treatment methods is quite high. In the 21^st century the possibility of isolated limb perfusion chemotherapy gives patients a high objective response to therapy without their systemic administration, improving quality of life through the limb salvage. This review describes currently used therapeutic agents, results of ongoing clinical trials and personal data.

Keywords

melanoma, sarcoma, treatment, perfusion

References

1. Kurbatov G.K. i soavt. Analiz lecheniya zlokachestvennoi melanomy kozhi v otdelenii obshchei onkologii GUZ AKOD za period s 2007 po 2009 g. Dostizheniya sovremennoi onkologii. Pod red. d-ra med. nauk prof. A.F. Lazareva. Barnaul, 2010.

2. Ryazantseva A.A. i soavt. Molekulyarno-biologicheskie podkhody k differentsial'noi diagnostike melanomy kozhi. Arkhiv patologii. Moskva, «Meditsina». 2009, t. 71, № 5.

3. Trishkin V.A. i soavt. Otsenka effektivnosti kombinirovannogo lecheniya bol'nykh pervichnymi sarkomami myagkikh tkanei konechnostei, podvergshikhsya sberegatel'nym operatsiyam. Voprosy onkologii. 2009, t. 55, № 6, s. 722-726.

4. Fedenko A.A., Gorbunova V.A. Lechenie disseminirovannykh sarkom myagkikh tkanei. Sostoyanie problemy v Rossii. Voprosy onkologii. 2009, t. 55, № 5, s. 644-648.

5. Chissov V.I. i soavt. Zlokachestvennye novoobrazovaniya v Rossii v 2007 godu (Zabolevaemost' i smertnost'). M., 2009.

6. Alexander H.R. Jr., Butler C.C. Development of isolated hepatic perfusion via the operative and percutaneous techniques for patients with isolated and unresectable liver metastases. Cancer J. 2010, v. 16 (2), p. 132-141.

7. Koops H.S., Vaglini M., Suciu S. et al. Prophylactic isolated limb perfusion for localized, high-risk limb melanoma: results of a multicenter randomized Phase III trial. European organization for research and treatment of cancer malignant melanoma cooperative group protocol 18832, the world health organization melanoma program trial 15, and the north american perfusion group southwest oncology group-8593. J. Clin. Oncol. 1998, v. 16 (9), p. 2906-2912.

8. Balch C.M., Buzaid A.C., Soong S.J. et al. Final version of the American joint committee on cancer staging system for cutaneous melanoma. Journal of Clinical Oncology. 2001, v. 19, No. 16, p. 3635-3648.

9. Creech O. Jr., Krementz E.T, Ryan R.F. et al. Chemotherapy of cancer: regional perfusion utilizing extracorporeal circuit. Ann. Surg. 1958, v. 148, p. 616-632.

10. De Wilt J.H., Manusama E.R et al. Prerequisites for effective isolated limb perfusion using tumour necrosis factor alpha and melphalan in rats. Br. J. Cancer. 1999, v. 80 (1-2), p. 161-166.

11. Eggermont A.M., de Wilt J.H.W., ten Hagen T.L.M. Current uses of isolated limb perfusion in the clinic and a model system for new strategies. Lancet Oncol. 2003, v. 4, p. 429-437.

12. Flaherty K.T., Puzanov I., Kim K.B. et al. Inhibition of mutated, activated BRAF in metastatic melanoma. The New England Journal of Medicine. 2010, v. 363, No. 9, p. 809-819.

13. Hayes A.J. Isolated limb perfusion with melphalan and tumor necrosis factor alpha for advanced melanoma and soft-tissue sarcoma. Ann. Surg. Oncol. 2007, v. 14(1), p. 230-238.

14. Hodi F.S., O’Day S.J., McDermott D.F. et al. Improved survival with ipilimumab in patients with metastatic melanoma. The New England Journal of Medicine. 2010, v. 363, No. 8, p. 711-723.

15. Hoekstra H.J. The European approach to in-transit melanoma lesions. International Journal of Hyperthermia. 2008, v. 24, No. 3, p. 227-237.

16. Klaase J.M, Kroon B.B et al. Prognostic factors for tumor response and limb recurrence-free interval in patients with advanced melanoma of the limbs treated with regional isolated perfusion with melphalan. Surgery. 1994, v. 115, p. 39-45.

17. Klaase J.M., Kroon B.B.R. et al. Relation between calculated melphalan peak concentrations and toxicity in regional isolated perfusion for melanoma. Reg. Cancer Treat. 1992, v. 4, p. 309-312.

18. Klauser J.M., Lev-Chelouche D., Meller I. et al. Isolated limb perfusion in the treatment of advanced soft-tissue sarcomas. Musculoskeletal Cancer Surgery. 2001, p. 75-84.

19. Klopp C.T., Alford T.C. et al. Fractional intra-arterial cancer chemotherapy. Ann. Surg. 1950, v. 132, p. 811-832.

20. Liénard D., Eggermont A.M. et al. Isolated limb perfusion with tumour necrosis factor-alpha and melphalan with or without interferon-gamma for the treatment of in-transit melanoma metastases: a multicentre randomized phase II study. Melanoma Res. 1999, v. 9 (5), p. 491-502.

21. McDermott D.F. et al. Dvoinoe slepoe randomizirovannoe issledovanie II fazy kombinatsii sorafeniba i dakarbazina u bol'nykh s rasprostranennoi melanomoi: soobshchenie issledovatel'skoi gruppy 11715. Journal of Clinical Oncology, russkoe izdanie. 2008, t. 2, № 3, s. 176-183.

22. Minor D.R., Allen R.E. et al. A clinical and pharmacokinetic study of isolated limb perfusion with heat and melphalan for melanoma. Cancer. 1985, v. 55, p. 2638-2644.

23. Pollock R.E. The seminal role of Cancer in our under- standing of sarcoma. Cancer. 2008, v. 113 (7 Suppl.), p. 1969-1979.

24. Ryan R.F., Krementz E.T. et al. Selected perfusion of isolated viscera with chemotherapeutic agents an using an extracorporeal circuit. S.Forum. 1957, v. 8, p. 158-161.

25. Thompson J.F., Gianoutsos M.P. Isolated limb perfusion for melanoma: effectiveness and toxicity of cisplatin compared with that of melphalan and other drugs. World J. Surg. 1992, v. 16 (2), p. 227-233.

26. Wernberg J.A. et al. Isolated regional Therapy. The Chemotherapy Source Book, Perry M.C. 2008, p. 99-107.

For citations:

Gafton G.I., Semiletova U.V., Senchik K.U., Belyaev A.M., Gafton I.G. Chemoperfusion as a method of choice in sarcomas treatment. Bone and soft tissue sarcomas, tumors of the skin. 2015;(4):42-47. (In Russ.)

This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 2219-4614 (Print)
ISSN 2782-3687 (Online)

Username
Password
	Remember me
Not a user? Register with this site Forgot your password?

Bone and soft tissue sarcomas, tumors of the skin

Chemoperfusion as a method of choice in sarcomas treatment

Full Text:

Abstract

Keywords

About the Authors

References

Review

For citations:

User

Bone and soft tissue sarcomas, tumors of the skin

Chemoperfusion as a method of choice in sarcomas treatment

Full Text:

Abstract

Keywords

About the Authors

References

Review

For citations:

Cookies policy