Pathomorphosis as a prognostic indicator of complex treatment with combination of intra-arterial chemotherapy in non-epithelial malignant tumors of the maxilla, nasal cavity and paranasal sinuses
Abstract
Background. To study a role of pathomorphosis as an index of the effectiveness of intra-arterial chemotherapy in non-epithelial malignancies of the maxilla, nasal cavity and paranasal sinuses.
Materials and methods. During the period 2000–2008 and in 2013–2015 48 patients with non-epithelial malignant tumors of the maxilla and the paranasal sinuses were treated. Patients depending on the method of treatment at the first stage were divided into 4 groups: 1) long intra-arterial chemotherapy with local UHF-hyperthermia and radiation therapy (10 patients); 2) long intra-arterial chemotherapy and radiation therapy (14 patients); 3) systemic chemotherapy and radiation therapy (12 patients); 4) radiation therapy with a subsequent operation (12 patients). After 3–4 weeks after completion of neoadjuvant treatment, the patients underwent surgery.
Results. A comparative study of the expression of the therapeutic pathomorphism in groups, it was found that the III–IV degree pathomorphosis in group 1 were detected in 4 (57%) patients in 2nd group – 5 (50%) in 3d group – 4 (36%) and the 4nd group – 2 (20%) patients. Analyzing the data by group, it shows that most pathomorphosisism stage III–IV was found in 1st group, then in the 2nd group of patients.
Conclusion. In patients who received neoadjuvant chemotherapy, a regional intraarterial direct morphological effect (degree pathomorphosisism) of treatment was greater than in patients who received systemic chemotherapy.
About the Authors
A. I. Khasanov
Head and Neck tumors department, National Research Center of Oncology MH of RUz
Russian Federation
Russian Federation
Tashkent
R. M. Bekmirzayev
Head and Neck tumors department, National Research Center of Oncology MH of RUz
Russian Federation
Russian Federation
Tashkent
D. A. Nishonov
Head and Neck tumors department, National Research Center of Oncology MH of RUz
Russian Federation
Russian Federation
Tashkent
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Review
For citations:
Khasanov A.I., Bekmirzayev R.M., Nishonov D.A. Pathomorphosis as a prognostic indicator of complex treatment with combination of intra-arterial chemotherapy in non-epithelial malignant tumors of the maxilla, nasal cavity and paranasal sinuses. Bone and soft tissue sarcomas, tumors of the skin. 2016;(1):45-50. (In Russ.)
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