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New therapeutic approaches in the treatment of chondrosarcoma

Abstract

Chondrosarcoma is the second most common malignant neoplasm of the skeleton, the complexity of its treatment is due to its radiation and chemoresistance, which significantly reduces the therapeutic potential of the treating doctor. In this article will be considered one of the ways to influence this tumor – the Hedgehog signaling pathway.

About the Authors

A. O. Akhov
Russian Scientific Center of Radiography and Radiology Ministry of Health of the Russian Federtion
Russian Federation

Moscow



V. V. Teplyakov
Russian Scientific Center of Radiography and Radiology Ministry of Health of the Russian Federtion
Russian Federation

Moscow



A. A. Fedenko
N.N. Blokhin Russian Cancer Research Center Ministry of Health of the Russian Federation
Russian Federation

Moscow



P. S. Sergeev
Russian Scientific Center of Radiography and Radiology Ministry of Health of the Russian Federtion
Russian Federation

Moscow



Y. A. Li
Russian Scientific Center of Radiography and Radiology Ministry of Health of the Russian Federtion
Russian Federation

Moscow



A. A. Shaposhnikov
Russian Scientific Center of Radiography and Radiology Ministry of Health of the Russian Federtion
Russian Federation

Moscow



A. V. Lazukin
Russian Scientific Center of Radiography and Radiology Ministry of Health of the Russian Federtion
Russian Federation

Moscow



References

1. Nusslein-Volhard et al. Nature. 1980, v. 287, p. 795-801.

2. Taipale et al. Nature. 2002, v. 418, p. 892.

3. Stone et al. Nature. 1996, v. 384, p. 129.

4. Bovée J.V.M.G., Cleton-Jansen A.M., Taminiau A.H.M., Hogendoorn P.C.W. Emerging pathways in the development of chondrosarcoma of bone and implications for targeted treatment. Lancet Oncol. 2005, v. 6 (8), p. 599-607.

5. VanOosterwijk J.G., HerpersB.,Meijer D. et al. Restoration of chemosensitivity for doxorubicin and cisplatin in chondrosarcoma in vitro:BCL-2 family members cause chemoresistance. Ann. Oncol. 2012, v. 23 (6), p. 1617-1626.

6. Wyman J.J., Hornstein A.M., Meitner P.A. et al. Multidrug resistance-1 and p-glycoprotein in human chondrosarcoma cell lines: expression correlates with decreased intracellular doxorubicin and in vitro chemoresistance. J. Orthop. Res. 1999, v. 17 (6), p. 935-940.

7. Frezza A.M., Cesari M., Baumhoer D. et al. Mesenchymal chondrosarcoma: prognostic factors and outcome in 113 patients. A European Musculoskeletal Oncology Society study. Eur. J. Cancer. 2015, v. 51 (3), p. 374-381.

8. Murphey M.D., Walker E.A., Wilson A.J., Kransdorf M.J., Temple H.T., Gannon F.H. From the archives of the AFIP: imaging of primary chondrosarcoma: radiologicpathologic correlation. Radiographics. 2003, v. 23 (5), p. 1245-1278.

9. Van Oosterwijk J.G., Anninga J.K., Gelderblom H., Cleton-Jansen A.M., Bovee J.V. Update on targets and novel treatment optionsfor high-grade osteosarcoma and chondrosarcoma. Hematol. Oncol. Clin. North Am. 2013, v. 27 (5), p. 1021-1048.

10. Zhang Y., Kalderon D. Hedgehog acts as a somatic stem cell factor in the Drosophila ovary. Nature. 2001, v. 410 (6828), p. 599-604.

11. Daya-GrosjeanL.,Couve-PrivatS.SonicHedgehog signaling in basal cell carcinomas. CancerLett. 2005, v. 225 (2), p. 181-192.

12. Rubin L.L., De Sauvage F.J. Targeting the Hedgehog pathway in cancer. Nat. Rev. Drug Discov. 2006, v. 5 (12), p. 1026-1033.

13. Tiet T.D., Hopyan S., Nadesan P. et al. Constitutive Hedgehog signaling in chondrosarcoma up-regulatestumor cell proliferation. Am. J. Pathol. 2006, v. 168 (1), p. 321-330.

14. Campbell V.T., Nadesan P., Ali S.A. et al. Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth. Mol. Cancer Ther. 2014, v. 13 (5), p. 1259-1269.

15. Xiang W., JiangT., Guo F. et al. Hedgehog pathway inhibitor-4 suppresses malignant properties of chondrosarcoma cells by disturbing tumor ciliogenesis. Oncol. Rep. 2014, v. 32 (4), p. 1622-1630.

16. Sun Y., Guo W., Ren T. et al. Gli1 inhibition suppressed cell growth and cell cycle progression and induced apoptosis as well as autophagy depending on ERK1/2 activity in human chondrosarcoma cells. Cell Death Dis. 2014, v. 5, e979.


Review

For citations:


Akhov A.O., Teplyakov V.V., Fedenko A.A., Sergeev P.S., Li Y.A., Shaposhnikov A.A., Lazukin A.V. New therapeutic approaches in the treatment of chondrosarcoma. Bone and soft tissue sarcomas, tumors of the skin. 2017;(2):16-21. (In Russ.)

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ISSN 2219-4614 (Print)
ISSN 2782-3687 (Online)