Evaluation of the proliferative activity of dermal fibroblasts in the presence of composite materials based on titanium silicides in vitro
Abstract
Objective. To evaluate the proliferative activity of dermal fibroblast cultures in the presence of composite materials based on titanium silicides in in vitro conditions.
Materials and methods. To assess the proliferative activity of dermal fibroblasts by in vitro direct contact test, with the use of titanium silicide, titanium carbosilicide oxidized in vacuum and without vacuum, titanium VT00 (comparison group). The proliferation index, the doubling time and the number of culture doubling during the cultivation time were calculated.
Results. To assess the proliferative activity of dermal fibroblasts by in vitro direct contact test, with the use of titanium silicide, titanium carbosilicide oxidized in vacuum and without vacuum, titanium VT00 (comparison group). The proliferation index, the doubling time and the number of culture doubling during the cultivation time were calculated.
Сonclusion. Active cell proliferation testifies to the non-toxicity and biocompatibility of the investigated alloys.
About the Author
A. N. Nikolaenko
Federal State Budget Educational Institution of Higher Education «Samara State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Samara
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Review
For citations:
Nikolaenko A.N. Evaluation of the proliferative activity of dermal fibroblasts in the presence of composite materials based on titanium silicides in vitro. Bone and soft tissue sarcomas, tumors of the skin. 2017;(3):32-37. (In Russ.)
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