Results of combined treatment of primary and recurrent locally advanced soft tissue sarcoma with the use of local hyperthermia
Abstract
Background. To estimate the effectiveness of locally advanced soft tissue sarcomas in patients treated with local hyperthermia in combination with preoperative radiation therapy and intraoperative radiotherapy.
Methods. 111 patients with locally advanced STS were analyzed. In the study group 56 patients were included, they received гadiation therapy, local hyperthermia and intraoperative radiotherapy. In the control group 55 patients the treatment was carried out according the same scheme but without local hyperthermia.
Results. The locoregionalrecurrencefreesurvival (LRFS), metastasisfree survival and overall survival rates (87,5; 91,07; 100%) at 2 years were higher in a study group, comparing to control group (76,2; 81,82; 90,91%) respectivly. Local hyperthermia didn’t increase incidence of postoperative complications.
Conclusion. Local hyperthermia was shown to be a promising treatment method that enhances tumor sensitivity to radiation therapy, reducing recurrence incidence and improving oncology and social results.
About the Authors
A. I. Konovalov
Federal State Budgetary Cancer Research Institution «Tomsk National Research Medical Center of the Russian Academy of Sciences»
Russian Federation
Russian Federation
Tomsk
Zh. A. Startseva
Federal State Budgetary Cancer Research Institution «Tomsk National Research Medical Center of the Russian Academy of Sciences»
Russian Federation
Russian Federation
Tomsk
Yu. I. Tyukalov
Federal State Budgetary Cancer Research Institution «Tomsk National Research Medical Center of the Russian Academy of Sciences»
Russian Federation
Russian Federation
Tomsk
A. V. Bogoutdinova
Federal State Budgetary Cancer Research Institution «Tomsk National Research Medical Center of the Russian Academy of Sciences»
Russian Federation
Russian Federation
Tomsk
O. V. Kotova
Federal State Budgetary Cancer Research Institution «Tomsk National Research Medical Center of the Russian Academy of Sciences»
Russian Federation
Russian Federation
Tomsk
P. K. Sitnikov
Federal State Budgetary Cancer Research Institution «Tomsk National Research Medical Center of the Russian Academy of Sciences»
Russian Federation
Russian Federation
Tomsk
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Review
For citations:
Konovalov A.I., Startseva Zh.A., Tyukalov Yu.I., Bogoutdinova A.V., Kotova O.V., Sitnikov P.K. Results of combined treatment of primary and recurrent locally advanced soft tissue sarcoma with the use of local hyperthermia. Bone and soft tissue sarcomas, tumors of the skin. 2017;(3):28-31. (In Russ.)
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