Radiation-induced osteosarcoma of the mandible
Abstract
The article describes one of the most controversial topics of oncology – radiation-induced tumors, in particular, sarcomas of the head and neck region.
Radiation therapy is one of the most important methods of treating malignant neoplasms in modern oncology as an independent variant (possibly in combination with chemotherapy) and as adjuvant treatment after the operation. however, with the improvement of the results of treatment of cancer patients, more attention is devote to the side effects and complications of radiotherapy. one of the most rare and late complications are radiation-induced tumors that develop in irradiated tissues after a certain latent period.
About the Authors
M. A. KropotovRussian Federation
G. O. Agabekyan
Russian Federation
Moscow
L. P. Yakovleva
Russian Federation
References
1. Thiagarajan A., Iyer N.G. Radiation-induced sarcomas of the head and neck. 2014, v. 5 (5), p. 973-981.
2. Huvos A.G., Woodard H.Q., Cahan W.G., Higinbotham N.L., Stewart F.W. et al. Postradiation osteogenic sarcoma of bone and soft tissues. A clinicopathologic study of 66 patients. Cancer. 1985, v. 15, 55 (6), p. 1244-1255.
3. King A.D., Ahuja A.T., Teo P., Tse G.M., Kew J. Radiation induced sarcomas of the head and neck following radiotherapy for nasopharyngeal carcinoma. Clin. Radiol. 2000, v. 55, p. 684-689.
4. Tay G.C., Iyer N.G., Ong W.S., Tai D., Ang M.K., Ha T.C. et al. Outcomes and Prognostic Factors of Radiation-Induced and de novo Head and Neck Squamous Cell Carcinomas. American Academy of Otolaryngology – Head and Neck Surgery. 2016, v. 154 (5), p. 880-887.
5. William G., Cahan M.D. Radiation-induced sarcoma – 50 years later. Cancer. 1998, v. 1, p. 6-7.
6. Chan J.Y., To V.S., Wong S.T., Wei W.I. Radiation-induced squamous cell carcinoma of the nasopharynx after radiotherapy for nasopharyngeal carcinoma. Head Neck. 2014, v. 36 (6), p. 772-775.
7. Cai P.Q., Wu Y.P, Li L., Zhang R., Xie C.M., Wu P.H. et al. CT and MRI of radiation-induced sarcomas of the head and neck following radiotherapy for nasopharyngeal carcinoma. Clin. Radiol. 2013, v. 68 (7), p. 683-689.
8. Pellitteri P.K., Ferlito A., Bradley P.J., ShahaA.R., RinaldoA. Management of sarcomas of the head and neck in adults. Oral. Oncol. 2003, v. 39, p. 2-12.
9. Samartzis D., Nishi N., Cologne J., Funamoto S., HayashiM., Kodama K., Miles E.F., Suyama A., Soda M., Kasagi F. Ionizing radiation exposure and the development of soft-tissue sarcomas in atomic-bomb survivors. J. Bone Joint. Surg. Am. 2013, v. 95, p. 222-229.
10. Samartzis D., Nishi N., Hayashi M., Cologne J., Cullings H.M., Kodama K. et al. Exposure to ionizing radiation and development of bone sarcoma: new insights based on atomic-bomb survivors of Hiroshima and Nagasaki. J. Bone Joint. Surg. Am. 2011, v. 93, p. 1008-1015.
11. Kuttesch J.F., Wexler L.H., Marcus R.B., Fairclough D., Weaver McClure L., WhiteM. et al. Second malignancies after Ewing’s sarcoma: radiation dose-dependency of secondary sarcomas. J. Clin. Oncol. 1996, v. 14, p. 2818-2825.
12. Mark R.J., Poen J., Tran L.M., Fu Y.S., Selch M.T. et al. Postirradiation sarcomas. A single-institution study and review of the literature. Cancer. 1994, v. 73, p. 2653-2662.
13. Gladdy R.A., Qin L.X., Moraco N., Edgar M.A., Antonescu C.R., Alektiar K.M., Brennan M.F., Singer S. Do radiation-associated soft tissue sarcomas have the same prognosis as sporadic soft tissue sarcomas? J. Clin. Oncol. 2010, v. 28, p. 2064-2069.
14. Gregory S.K. Lau, Jimny Y.W. Chan, William L. Wei. Role of the surgery in treatment of radiation induced sarcomas of the head and neck. J. Sci. Ther. 2011, s. 2, p. 25-30.
Review
For citations:
Kropotov M.A., Agabekyan G.O., Yakovleva L.P. Radiation-induced osteosarcoma of the mandible. Bone and soft tissue sarcomas, tumors of the skin. 2017;(3):8-13. (In Russ.)