The first experience of electrochemotherapy in the treatment of patients with melanoma of the skin superficial metastasis
Abstract
Objective. Demonstration of the use of electrochemotherapy (ECT) in the treatment of superficial metastases of skin melanoma.
Materials and methods. ECT was performed in 4 patients with stage IV skin melanoma. Bleomycin was administered intravenously bolus 15 mg/m2. The effects of electrical impulses on each tumor site and adjacent tissues were performed through the needle electrode of a pulse generator (Cliniporator, Igea, Modena, Italy).
Results. In all patients, after 15–30 days from the time of ECT, complete regression of the tumor nodes was observed. In 2 patients from the moment of ECT there is no recurrence and growth of new foci within 10 months. In 1 patient 3 months after the ECT there was a relapse of the tumor, in 1 – in 5 months there was a relapse of metastatic formations and the appearance of new foci in the nearby anatomical areas.
The conclusion. ECT can be a method of choice of treatment in patients with superficial melanoma metastases, which allows to increase the effectiveness of systemic and local therapy.
About the Authors
G. R. Serikbaev
Kazakh scientific research institute of oncology and radiology
Kazakhstan
Kazakhstan
Almaty
D. A. Tuleuova
Kazakh scientific research institute of oncology and radiology
Kazakhstan
Kazakhstan
Almaty
A. K. Kurmanaliyev
Kazakh scientific research institute of oncology and radiology
Kazakhstan
Kazakhstan
Almaty
K. M. Ormanov
Kazakh scientific research institute of oncology and radiology
Kazakhstan
Kazakhstan
Almaty
References
1. Gogas H.J., Kirkwood J.M., Sondak V.K. Chemotherapy for metastatic melanoma: time for a change? Cancer. 2007, v. 109 (3), p. 455-464.
2. Overett T.K., Shiu M.H. Surgical treatment of distant metastatic melanoma. Cancer. 1985, v. 565, p. 1222.
3. Бохян Б.Ю. Буров Д.А., Божченко Я.А., Тарарыкова А.А. Первично-множественная меланома кожи. Саркомы костей, мягких тканей и опухоли кожи. 2016, № 1, с. 76-80.
4. Krementz E.T., Carter R.D., Sutherland C.M., Muchmore J.H., Ryan R.F., Creech O. Jr. Regional chemotherapy for melanoma. A 35-year experience. Ann. Surg. 1994, v. 220 (4), р. 520-535.
5. Abhirami Hallock, MD, Olga Vujovic, MD, Edward Yu, MD. Is radiotherapy an еffective treatment option for recurrent metastatic malignant melanoma? A case report of short-course, large-fraction radiation and a literature review. Can. J. Plast. Surg. 2011, v. 19 (4), р. 153-155.
6. Corrado Caracò, Nicola Mozzillo, Ugo Marone, Ester Simeone, Lucia Benedetto, Gianluca Di Monta, Maria Luisa Di Cecilia, Gerardo Botti and Paolo Antonio Ascierto. Long-lasting response to electrochemotherapy in melanoma patients with cutaneous metastasis. BMC Cancer. 2013, v. 13, р. 564.
7. Mir L.M., Glass L.F., Sersa G., Teissié J., Domenge C., Miklavcic D., Jaroszeski M.J., Orlowski S., Reintgen D.S., Rudolf Z., Belehradek M., Gilbert R., Rols M.P., Belehradek J. Jr., Bachaud J.M., DeConti R., Stabuc B., Cemazar M., Coninx P., Heller R. Effective treatment of cutaneous and subcutaneous malignant tumors by electrochemotherapy. Br. J. Cancer. 1998, v. 77 (12), р. 2336-2342.
8. John O. Larkin, MB, AFRCSI, Christopher G. Collins, PhD, AFRCSI, Simon Aarons, PhD, Mark Tangney, PhD, Maria Whelan, MB, AFRCSI, Seamus O’Reily, BSc, MD, PhD, FRCPI,† Oscar Breathnach, MB, MRCPI,† Declan M. Soden, BSc, PhD, and Gerald C. O’Sullivan, MCh, FRCSI, FRCSG (Hons), FACS. Electrochemotherapy Aspects of Preclinical Development and Early Clinical Experience. Ann. Surg. 2007, v. 245 (3), р. 469-479.
9. Кайдарова Д.Р., Ауэзова Э.Т., Чингисова Ж.К., Сейсенбаева Г.Т., Ажмагамбетова А.Е., Жылкайдарова А.Ж. Показатели онкологической службы Республики Казахстан за 2015 год. С. 126, 142-143, 145.
10. American Cancer Society. Cancer Facts and Figures 2016. Atlanta: American Cancer Society. 2017.
11. Balch C.M., Soong S.J., Gershenwald J.E., Thompson J.F., Reintgen D.S., Cascinelli N., Urist M., McMasters K.M., Ross M.I., Kirkwood J.M., Atkins M.B., Thompson J.A., Coit D.G., Byrd D., Desmond R., Zhang Y., Liu P.Y., Lyman G.H., Morabito A. Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. J. Clin. Oncol. 2001, v. 19 (16), р. 3622-3634.
12. Campana L.G., Valpione S., Mocellin S., Sundararajan R., Granziera E., Sartore L., Chiarion-Sileni V., Rossi C.R. Electrochemotherapy for disseminated superficial metastases from malignant melanoma. Br. J. Surg. 2012, v. 99 (6), р. 821-830.
13. Larkin J.O., Collins C.G., Aarons S., Tangney M., Whelan M., O’Reily S., Breathnach O., Soden D.M., O’Sullivan G.C. Electrochemotherapy: aspects of preclinical development and early clinical experience. Ann. Surg. 2007, v. 245 (3), р. 469-479.
14. Marko Snoj, Maja Cemazar, Breda Slekovec Kolar, Gregor Sersa. Effective Treatment of Multiple Unresectable Skin Melanoma Metastases by Electrochemotherapy. Croat. Med. J. 2007, v. 48 (3), р. 391-395.
Review
For citations:
Serikbaev G.R., Tuleuova D.A., Kurmanaliyev A.K., Ormanov K.M. The first experience of electrochemotherapy in the treatment of patients with melanoma of the skin superficial metastasis. Bone and soft tissue sarcomas, tumors of the skin. 2017;(4):28-33. (In Russ.)
Views:
1320
Email this article 
