Fibroblstic sarcomas
Abstract
Fibroblastic sarcomas are a heterogeneous group of tumors that account for about 1% of adult cancers. The group includes 11 low-grade and high-grade tumors located on the extremities and trunk. All tumors composed of neoplastic fibroblasts and myofibroblasts. Fibroblastic sarcomas are rare and not well studied. Little is known about it histology, genetic, natural history or optimal treatment. This article summarizes what is known to date about fibroblastic sarcomas, including classification, epidemiology, approach to diagnosis and outcomes of these tumors.
References
1. Abbott J.J, Olivera A.M., Nascimento A.G. The prognostic significance of fibrosarcomatous transformation in dermatofibrosarcoma protuberans. Am. J. Surg. Pathol. 2006, v. 30, p. 305-309.
2. Andersen H.D. Fibroblastic tumors in children. A.M. A. Arch. Pathol. 1951, v. 51, p. 548-552.
3. Angervaal L., Kindblom L.G., Merck C. Myxofibrosarcoma. A study of 30 cases. Acta Pathol. Microbiol. Scand [A]. 1977, v. 85A, p. 127-140.
4. Antonescu C.R., Erlandson R.A., Huvos A.G. Primary fibrosarcoma and malignant fibrous histiocytoma of bone. Ultrastruct. Pathol. 2000, v. 24, p. 83-91.
5. Antonescu C.R., Rosenblum M.K., Pereira P. еt al. Sclerosing epithelioid fibrosarcoma: a study of 16 cases and confirmation of a clinicopathologically distinct tumor. Am. J. Surg. Pathol. 2001, v. 25, p. 699-709.
6. Bahrami A., Folpe A.L. Adult type fibrosarcoma: a reevaluation of 163 putative cases diagnosed at a single institution over 48-year period. Am. J. Surg. Pathol. 2010, v. 34, p. 1504-1513.
7. Borst M. Die Lehre von den Geschwulsten mit einem mikroskopischen Atlas. Wiesbaden: Bergmann. 1902.
8. Chung E.B., Enzinger F.M. Infantile fibrosarcoma. Cancer (Philad.). 1976, v. 38, p. 729-734.
9. Coffin C.M., Dehner L.P. Fibroblastic-myofibroblastic tumors in children and adolescents: a clinicopathologic study of 108 examples in 103 patients. Pediatr. Pathol. 1991, v. 11, p. 569-588.
10. Coffin C.M., Watterson J., Priest J.R. et al. Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am. J. Surg. Pathol. 1995, v. 19, p. 859-872.
11. Coffin C.M., Patel A., Perkins S. et al. ALK1 and p80 expression and chromosomal rearrangements involving 2p23 in inflammatory myofibroblastic tumor. Mod. Pathol. 2001, v. 14, p. 569-576.
12. Cools J., Wlodarska I., Somers R. Identification of novel fusion partners of ALK in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor. Genes Chromosomes Cancer. 2002, v. 34, p. 354-362.
13. Deyrup A.T., Weiss S.W. Grading of soft tissue sarcomas. Histopathology. 2006, v. 48, p. 42-50.
14. Evans H.L. Low-grade fibromixoid sarcoma. Am. J. Clin. Pathol. 1987, v. 88, p. 615-619.
15. Eyden B.P., Christensrn L. Leiomyosarcoma versus myofirosarcoma: observations and terminology. Ultrastruct. Pathol. 1993, v. 17, p. 231-239.
16. Fisher C. Low-grade sarcomas with CD34-positive fibroblasts and low grade myofibroblastic sarcomas. Ultrastruct. Pathol. 2004, v. 28, p. 291-305.
17. Fisher C. Myofibrosarcoma. Virchows Arch. 2004, v. 445, p. 215-223.
18. Fletcher C.D.M., Unni K.K., Mertens F. eds. Pathology and Genetics of Tumors of Soft Tissue and Bone. World Health Organization Classification of Tumours. Lyon: IARC Press. 2001.
19. Folpe A.L., Lane K.L., Paull G. еt al. Low-grade fibromyxoid sarcoma and hyalinizing spindle cell tumor with giant rosettes: a clinicopathologic study of 73 cases supporting their identity. Am. J. Surg. Pathol. 2000, v. 24, p. 1353-1360.
20. Jemal A., Siegel R. World Cancer Statistics, 2006. CA Cancer. J. Clin. 2006, v. 56, p. 106.
21. Hallor K.H., Sciot R., Staaf J. et al. Two genetic pathways t(1;10) and amplification of 3p11-12 in myxoinflammatory fibroblastic sarcoma. J. Pathol. 2009, v. 217, p. 716-727.
22. Hansen T, Katenkamp K., Brodhun M., Katenkamp D. Low grade fibrosarcoma. Histopathology. 2006, v. 49, p. 152-160.
23. Karakousis C.P., Perez R.P. Soft Tissuue Sarcomas in Adults. Cancer (Philad.). 1994, v. 44, p. 200-210.
24. Kindblom L.G., Merck C., Svendsen P. Myxofibrosarcoma: a pathologico-anatomical, angiographic correlative study of eight cases. Br. J. Radiol. 1977, v. 50, p. 876-887.
25. Knezevich S.R., McFadden D.E., Tao W et al. ETV6-NTRK3 gene fusion in congenital fibrosarcoma. Nat. Genet. 1998, v. 18, р. 184-187.
26. Konstantinopoulos P.A., Fountzilas E., Goldsmith J.D. et al. Analysis of multiple sarcoma expression datasets: implication for classification, oncogenic pathway activation and chemotherapy resistance. PloS ONE. 2010, v. 5, p. 9747-9753.
27. Lagace R., Schurch W., Seemayer T.A. Myofibroblasts in soft tissue sarcomas. Virchows Arch. A Pathol. Anat. Histol. 1980, v. 389, p. 1-11.
28. Lagace R., Seemayer T.A., Schurch W et al. Myofibroblastic sarcoma. Am. J. Surg. Pathol. 1999, v. 23, p. 1432-1446.
29. Lane K.L., Shannon R.J., Weiss S.W. Hialinizing spindle cell tumor with giant rosettes A distinctive tumor closely resembling low grade fibromyxoid sarcoma. Am. J. Surg. Pathol. 1997, v. 21, p. 1481-1488.
30. Mackenzie D.H. The differential diagnosis of fibroblastic disorders. Oxford: Blackwell Scientific Publications. 1970.
31. Matushansky I., Maki R.G. Mechanisms of sarcomagenesis. Haematology and Oncology clinics of North America. 2005, v. 3, p. 427-449.
32. Meis J.M., Enzinger F.M. Inflammatory fibrosarcoma of the mesentery and retroperitoneum. A tumor closely simulating inflammatory pseudotumor. Am. J. Surg. Pathol. 1991, v. 15, p.1146-1154.
33. Meis-Kindblom J.M., Kindblom L.G., Enzinger F.M. Sclerosing epithelioid fibrosarcoma. Am. J. Surg. Pathol. 1995, v. 19, p. 979-993.
34. Meis-Kindblom J.M., Kindblom L.G. Acral myxoinflammatory fibroblastic sarcoma. Am. J. Surg. Pathol. 1998, v. 22, p. 911-924.
35. Mentzel T., Calonje E., Wadden C. et al. Mixofibrosarcoma. Clinicopathologic analisis of 75 cases with emphasis on low grade variant. Am. J. Surg. Pathol. 1996, v. 20, p. 391-405.
36. Mentzel T., Beham A., Katenkamp D., Dei Tos A.P., Fletcher C.D.M. Fibrosarcomatous (high-grade) dermatofibrosarcoma protuberans: clinicopathologic and immunohistochemical study of a series of 41 cases. Am. J. Surg. Pathol. 1998, v. 22, p. 576-587.
37. Mentzel T., Dry S., Katenkamp D. et al. Low-grade myofibro-blastic sarcoma: analisis of 18 cases in spectrum myofibroblastic tumors. Am. J. Surg. Pathol. 1998, v. 22, p. 1228-1234.
38. Montgomery E., Devaney K.O., Giordano TJ. et al. Inflammatory myxohyaline tumor of distal extremities with virocyte or Reed-Sternberg-like cells. Mod. Pathol. 1998, v. 11, p. 384-391.
39. Montgomery E., Goldblum J.R., Ficher C. Myofibrosarcoma: a clinicopathologic study. Am. J. Surg. Pathol. 2001, v. 25, p. 219-228.
40. Montgomery E., Fisher C. Myofibroblastic differentiation in malignant fibrous histiocytoma (pleomorphic myofibrosarcoma): a clinicopathological study. Histopathology 2001, v 8, p. 499-509.
41. Mosquera J-M., Fletcher C.D.M. Expanding the spectrum of malignant progression in solitary fibrous tumors. Am. J. Surg. Pathol. 2009, v. 33, p. 1314-1321.
42. Murray E.M., Werner D., Greef E.A. et al. Postradiation sarcomas: 20 cases and a literature review. Int. J. Radiat. Oncol. Biol. Phys. 1999, v. 45, p. 951-964.
43. Nielsen G.P., O'Connel J.X., Dickersin G.R., Rosenberg A.E. Solitary fibrous tumor of soft tissue: a report 15 cases including 5 malignant examples. Mod. Pathol. 1997, v. 10, p. 1028-1037.
44. Panagopuulos I., Storlazzi C.T., Fletcher C.D. et al. The chimeric FUS/CREB3l2 gene is specific for low grade fibromyxoid sarcoma. Genes Chromosomes Cancer. 2004, v. 40, p. 218-228.
45. Pritchard D.J., Soule E.H., Taylor W.F. et al. Fibrosarcoma: a clinicopathologic and statistical study of 199 tumors of the soft tissues of the extremities and trunk. Cancer (Philad.). 1974, v. 33, p. 888-897.
46. Scott S.M., Reiman H.M., Pritchard D.J. Soft tissue fibrosarcoma. A clinicopathologic study of 132 cases. Cancer (Philad.). 1989, v. 64, p. 925-931.
47. Shurch W., Seemayer T.A., Gabbiani G. The myofibroblast. Am. J. Surg. Pathol. 1998, v. 22, p. 141-147.
48. Simon M.P., Pedeutor F., Sirvent N. et al. Deregulation of the plateled-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. Nat. Genet. 1997, v. 15, p. 95-98.
49. Spunt S.L., Skapek S.X., Coffin C.M. Pediatric Nonrhabdomyosarcoma Soft Tissue Sarcomas. The Oncologist. 2008, v. 13, p. 668-678.
50. Stout A.P. Fibrosarcoma. The malignant tumor of fibroblasts. Cancer (Philad.). 1948, v. 1, p. 30-63.
51. Stout A.P. Fibrosarcoma in infant and children. Cancer (Philad.). 1962, v. 15, p. 1028-1040.
52. Suh C.H., Ordones N.G., Mackay B. Fibrosarcoma: observations on the ultrastructure. Ultrastruct. Pathol. 1993, v. 17, p. 221-229.
53. Tardio J.C. CD34-reative tumors of the skin. An update review of an ever-growing list of lesions. J. Cutan. Pathol. 2009, v. 36, p. 89-102.
54. Vallet-Decouvelaere A.V., Dry S.M., Fletcher C.D.M. Atipical and malignant solitary fibrous tumors in extratoracic locations: evidence of their comparability to intra-thoracic tumors. Am. J. Surg. Pathol. 1998, v. 22, p. 1501-15011.
55. Van de Rijn M., Rouse R.V. CD34: a review. Appl. Immunohistochem. 1994, v. 2, p. 71-80.
56. Wilks S. Lecture on pathological anatomy. London: Longman. 1859.
57. Weiss S.W., Enzinger F.M. Myxoid variant of malignant fibrous histiocytoma. Cancer (Philad.). 1977, v. 39, p. 1672-1685.
Review
For citations:
Bliznyukov O.P. Fibroblstic sarcomas. Bone and soft tissue sarcomas, tumors of the skin. 2012;(2):22-33. (In Russ.)
Views:
444
Email this article 
