TOWARDS INDIVIDUALIZED TREATMENT: PREDICTIVE FACTORS FOR CHEMOTHERAPY RELATED TOXIC EFFECT
Abstract
Many drugs have been used for the treatment of cancer patients, but there is little information about how predictive factors can be used to aid treatment response and anticipate toxic effect related to anticancer treatment. There is a marked variability in drug handling between individual patients and this variability is based on genotyping individual patients. In this review we focus on genetic characteristics of xenobiotic-metabolizing enzymes. We also discuss the most valuable genetic predictive factors that relate to the toxic effects experienced by cancer patients treated with anticancer chemotherapy and the future prospects in this field of investigation.
About the Authors
М. Абрамов
Российский онкологический научный центр им. Н.Н. Блохина РАМН
Russian Federation
Russian Federation
А. Шварова
Российский онкологический научный центр им. Н.Н. Блохина РАМН
Russian Federation
Russian Federation
Е. Степанова
Российский онкологический научный центр им. Н.Н. Блохина РАМН
Russian Federation
Russian Federation
M. E. Abramov
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
A. V. Shvarova
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
E. V. Stepanova
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
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Review
For citations:
, , , Abramov M.E., Shvarova A.V., Stepanova E.V. TOWARDS INDIVIDUALIZED TREATMENT: PREDICTIVE FACTORS FOR CHEMOTHERAPY RELATED TOXIC EFFECT. Bone and soft tissue sarcomas, tumors of the skin. 2011;(4):73-76. (In Russ.)
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