Нейрофиброматоз: генетическая гетерогенность и дифференциальная диагностика
Аннотация
Понятие «нейрофиброматоз» объединяет ряд генетически самостоятельных нозологических форм - нейрофиброматоз тип 1, нейрофиброматоз тип 2, шванноматоз, а также ряд клинических состояний неясной этиологии. В обзоре приводятся диагностические критерии нейрофиброматоза 1 - и 2-го типов, шванноматоза, современные данные литературы по молекулярно-генетическим аспектам патологии: этиологии, фенотип-генотип корреляциям, представления о механизмах патогенеза и подходах к лечению.
Об авторах
Л. Н. Любченко
НИИ клинической онкологии РОНЦ им. Н.Н. Блохина РАМН
Россия
Россия
М. Г. Филиппова
НИИ клинической онкологии РОНЦ им. Н.Н. Блохина РАМН
Россия
Россия
L. Lubchenko
N.N. Blokhin Russian Cancer Research Center
Россия
Россия
M. Filippova
N.N. Blokhin Russian Cancer Research Center
Россия
Россия
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Рецензия
Для цитирования:
Любченко Л.Н., Филиппова М.Г., , Нейрофиброматоз: генетическая гетерогенность и дифференциальная диагностика. Саркомы костей, мягких тканей и опухоли кожи. 2011;(4):29-36.
For citation:
, , Lubchenko L.N., Filippova M.G. NEUROFIBROMATOSIS - CLINICAL POLYMORPHISM AND TREATMENT APPROACHES. Bone and soft tissue sarcomas, tumors of the skin. 2011;(4):29-36. (In Russ.)
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