BONE CHONDROSARCOMA DIAGNOSTIC DIFFICULTIES OF VARYING MALIGNANCY GRADES

Abstract

Biopsy and operating material was analyzed in patients who were diagnosed with bone chondrosarcoma and underwent surgery in the departments of CITO clinic named by N. Priorov since 1987 to 2009 years. Clinical and morphological features of chondrosarcoma were assessed by three grade of malignancy which based on the histologic features such as the size of the nucleus, mitotic activity, the presence of binuclear and polynuclear cells, cell density, the nature of the extracellular matrix, as well as clinical and radiological data. Among 458 cases which were diagnosed during this period as a conventional chondrosarcoma, 228 cases (49,78%) were classified as a low, 152 (33,18%) as a middle and 78 (17,03%) as a high degree of malignancy. Regardless of grade chondrosarcoma most commonly affects the femur, pelvis, humerus. Histological differences of chondroproducing benign and lowgrade malignant tumors are minimal and greatly subjective, that dictates the necessity of more objective estimation methods to grade cartilage forming tumors. In the some cases, the histological criteria for malignancy of chondrosarcoma are depending on anatomical localization of the pathological process. Cytological and histological diagnosis of chondrosarcoma should be based on the data from the mandatory clinics and methods of radiation diagnosis in specialized centers, dealing with bone cancer.