Content of soluble form of vascular endothelial adhesion molecule type 1 (sVCAM-1) in the serum of patients with bone tumors
Abstract
Представлены результаты сравнительного анализа уровней sVCAM-1 в сыворотке крови практически здоровых людей (n=50), больных злокачественными (n=152) и пограничными (n=14) опухолями костей с учетом основных клинических и морфологических характеристик заболевания. У пациентов с новообразованиями костей среднее содержание sVCAM-1 в сыворотке крови было достоверно выше, чем у практически здоровых людей. Не выявлено различий в содержании sVCAM-1 при пограничных и злокачественных опухолях костей. У пациентов с положительным эффектом от химиотерапевтического лечения, соответствующим 3-4-й степени лечебного патоморфоза опухоли, исходные уровни sVCAM-1 были ниже по сравнению с больными, у которых отметили резистентность к химиотерапии или 1-2-ю степень лечебного патоморфоза.
About the Authors
I. V. Babkina
Moscow University of Medicine and Dentistry
Russian Federation
Russian Federation
E. Yu. Russo
Moscow University of Medicine and Dentistry
Russian Federation
Russian Federation
Yu. N. Soloviev
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
I. N. Kuznetsov
Moscow University of Medicine and Dentistry
Russian Federation
Russian Federation
E. A. Ten
Moscow University of Medicine and Dentistry
Russian Federation
Russian Federation
N. E. Kushlinsky
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
M. D. Aliev
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
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Review
For citations:
Babkina I.V., Russo E.Yu., Soloviev Yu.N., Kuznetsov I.N., Ten E.A., Kushlinsky N.E., Aliev M.D. Content of soluble form of vascular endothelial adhesion molecule type 1 (sVCAM-1) in the serum of patients with bone tumors. Bone and soft tissue sarcomas, tumors of the skin. 2012;(1):52-54. (In Russ.)
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