The first expirience in the evaluation of the preoperative chemoterapy in a patient with a soft tissue sarcoma using dynamic contrast-enhanced magnetic resonance imaging
Abstract
Soft tissue sarcomas (STS) are rare mesodermal tumors represent approximately 1% of malignant neoplasms in adults. The pattern of growth, clinical behaviour and prognosis refer soft tissue sarcomas to one of the most malignant tumors. The survival rate of the patients with STS mostly depends on the effective and early started treatment. Over the past decades, the success in the treatment of STS was reached due to development and use of neoadjuvant chemotherapy. That is why grows the necessity in evaluation of efficiency of chemotherapy to modify the initial therapeutic approach. A newer functional imaging technique, such as dynamic contrast-enhanced MRI (DCE MRI), is being developed for better evaluation of response to preoperative treatment. Review of the literature identifies a high potential of DCE MRI in detection of highly vascularized zones in tumor, which correlate with zones of residual viable tumor on pathologic examination. In this preliminary report of a clinical trial of DCE MRI is shown a high informativeness of the method in assessing of response to chemotherapy in a patient with clear cell sarcoma of soft tissues.
About the Authors
Y. A. Zamogilnaya
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
N. V. Kochergina
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
B. Y. Bokhyan
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
O. A. Anurova
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
A. B. Bludov
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
A. S. Nered
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
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Review
For citations:
Zamogilnaya Y.A., Kochergina N.V., Bokhyan B.Y., Anurova O.A., Bludov A.B., Nered A.S. The first expirience in the evaluation of the preoperative chemoterapy in a patient with a soft tissue sarcoma using dynamic contrast-enhanced magnetic resonance imaging. Bone and soft tissue sarcomas, tumors of the skin. 2011;(2):78-82. (In Russ.)
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