Thermo-chemo-radio-therapy in the combined treatment of locally advanced soft tissue sarcomas (STS)

118 patients with locally advanced STS examined and treated in MRRC were analyzed. In group 1 were included 31 patients treated by only surgery (S). The group 2 consisted of 33 patients treated with preoperative chemo-radiotherapy (CRT) followed by S. The group 3 included 22 patients received preoperative thermo-chemo-radiotherapy (TCRT) and S. The group 4 consisted of 32 patients, who received preoperative TCRT and S with intraoperative radiation therapy (IORT). Preoperative TCRT increased number of patients with stage III & IV of tumor therapeutic pathomorphism. TCRT and IORT didn't increase an incidence of complications and allowed to perform an increase organ-saving operations. None of the patients in group with TCRT had local recurrence during 3-5 years. The locoregional-recurrence-free-survival (LRFS), metastasis-free survival and overall survival rates (73-100, 56-88, 68-95%) were higher in group with combined treatment compared to first group (30, 20,5, 29%) respectively.

soft tissues sarcomas, combined treatment, local hyperthermia, radiation therapy, thermo-chemo-radiotherapy

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