Breast sarcomas and phyllodes tumors. Clinical and genetic features
Abstract
Complex research which helps to answer a part of the questions, concerning phyllodes tumors treatment diagnostics was carried out. These tumors are characterized as tumors that have a two component structure with the predominant development of mesenchymal component, which in sarcomas is the absolute part. In molecular genetic position it is shown, that germinal mis-sense mutation R1699W of BRCA1 gene carriers have high probability of malignant phyllodes tumor developing and allelic losses at locus D22S264 ofTP5 gene determine the progression of the disease.
About the Authors
I. K. Vorotnikov
N.N. Blokhin Russian Cancer Research Center, RussianAcademy of Medical Sciences
Russian Federation
Russian Federation
D. A. Denchik
N.N. Blokhin Russian Cancer Research Center, RussianAcademy of Medical Sciences
Russian Federation
Russian Federation
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Review
For citations:
Vorotnikov I.K., Denchik D.A. Breast sarcomas and phyllodes tumors. Clinical and genetic features. Bone and soft tissue sarcomas, tumors of the skin. 2010;(4):24-29. (In Russ.)
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