Пэгфилграстим в профилактике и лечении постцитостатической нейтропении
Аннотация
Нейтропения является одним из самых частых осложнений цитостатической терапии. Для снижения риска развития нейтропенических осложнений почти два десятилетия используются миелоидные факторы роста. Современные рекомендации предполагают рутинное использование факторов роста при риске развития фебрильной нейтропении более 20%. Миелоидные факторы роста сокращают продолжительность нейтропении и позволяют проводить дозо-интенсивные и уплотненные режимы в полном объеме. Пэгфилграстим - пэгилированный рекомбинантный гранулоцитарный колониестимулирующий фактор (G-CSF) пролонгированного действия. В каждом цикле химиотерапии препарат вводится только один раз. Данные ряда исследований свидетельствуют, что пэгфилграстим не уступает филграстиму в профилактике нейтропении, но эффективнее снижает частоту фебрильной нейтропении. В обзоре рассматриваются нейтропения и ее осложнения, фармакологические свойства и опыт клинического применения пэгфилграстима.
Об авторах
А. А. Феденко
Российский онкологический научный центр им Н.Н. Бохина РАМН
Россия
Россия
Д. Л. Строяковский
62-я городская клиническая больница
Россия
Россия
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Рецензия
Для цитирования:
Феденко А.А., Строяковский Д.Л. Пэгфилграстим в профилактике и лечении постцитостатической нейтропении. Саркомы костей, мягких тканей и опухоли кожи. 2010;(3):54-62.
For citation:
Fedenko A.A., Stroyakovsky D.L. Pegfilgrastim in the treatment and prophylaxis of postcytostatic neutropenia. Bone and soft tissue sarcomas, tumors of the skin. 2010;(3):54-62. (In Russ.)
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