Ultrasound evaluation of the local metastasis of primary melanoma
Abstract
Background. The aim of our study was to improve the diagnosis of cutaneous melanoma by synthesis, systematization and development of new ultrasound criteria for the primary tumor. Materials and methods. The prospective analysis of the ultrasound study results of primary skin melanoma of different localization in 140 patients. The results of preoperative ultrasound examination were compared with data of histology of the resected tumor. Results. Ultrasonic semiotic signs of the primary tumor were developed. A dependence of the ultrasound picture of the thickness of melanoma was revealed. The most common characteristics of primary skin melanoma are homogeneous structure of low echogenicity (85 (65,9%) cases) and fusiform (79 (61,2%) cases). Conclusion. Ultrasound allows to evaluate the local metastasis of primary skin melanoma and measure its thickness (r=0,91; p<0,001) on pre-operative stage with a high degree of confidence. This contributes early selection of appropriate treatment and increase survival of patients with malignant cutaneous melanoma.
About the Authors
G. S. Allakhverdyan
N.N. Blokhin Russian Cancer Research Center, Russian Academy ofMedical Sciences
Russian Federation
Russian Federation
M. A. Chekalova
N.N. Blokhin Russian Cancer Research Center, Russian Academy ofMedical Sciences
Russian Federation
Russian Federation
N. V. Kokosadze
N.N. Blokhin Russian Cancer Research Center, Russian Academy ofMedical Sciences
Russian Federation
Russian Federation
References
1. Eyre H.J., Smith R.A., Mettlin C.J. Melanoma and Nonmelanoma Skin. Cancer Med. Ed.: Bast R.C., Kufe D.W, Pollock R.E., Weichselbaum R.R., Holland J.F., Frei E., Gansler T.S.
2. Landis S.H., Murray T., Bolden S., Wtngo P.A. Cancer statistics, 1999 CA. CancerJ. Clin. 1999, v. 49,p. 18-33.
3. Лалетин В.Е, Минакин Н.И., Кожевников А.Б. Диагностика и лечение меланомы кожи. Сиб. мед. журн. 1995, № 1,т.2,с.43-49.
4. Селюжинский И.В., Найденов Ю.Н. Некоторые вопросы диагностики и лечения меланомы кожи. Вестник дерматолог. и венеролг. 1995, № 2, с. 59-62.
5. Breslow A. Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. Ann. Surg. 1970, v. 172, p. 902-908.
6. Lassau N., Koscielny S., AvrilV-F. et al. Prognostic Value of Angiogenesis Evaluated with High- Frequency and Color Doppler Sonography for Preoperative Assessment of Melanomas. AJR2002, v. 178, p. 1547-1551.
7. Harland C.C., Kale S.G., Jackson P. et al. Differentiation of common benign pigmented skin lesions from melanoma by high-resolution ultrasound. Br. J. Dermatol. 2000, v. 143 (2), p. 281-289.
8. Pennasilico G., Santini A., Bono R. etal. Preoperative ultrasonographic measurement of melanoma thickness with 20 MHz probe. Radiol. Med. (Torino). 1994, v. 88 (4), p. 388-391.
9. Гланц С. Медико-биологическая статистика. Пер. с англ. М., «Практика». 1999, 459 с.
10. Реброва О.Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ STATISTICA. М., «МедиаСфера». 2003, 312 с.
Review
For citations:
Allakhverdyan G.S., Chekalova M.A., Kokosadze N.V. Ultrasound evaluation of the local metastasis of primary melanoma. Bone and soft tissue sarcomas, tumors of the skin. 2010;(2):60-63. (In Russ.)
Views:
78
Email this article 
