The combined treatment oflocally advanced soft tissue. Sarcomas (STS)
Abstract
115 patients with locally advanced STS treated in MRRC RAMS were analyzed. In group 1 were included 32 patients who received preoperative thermo-chemo-radiotherapy (TCRT) and surgery with intraoperative radiation therapy (IORT). The group 2 consisted of 31 patients treated with preoperative chemo-radiotherapy (CRT) followed by surgery with IORT. The group 3 included 22 patients received TCRT, without surgery. The control group consisted of 30 patients treated with surgery only. IORT didn’t increase an incidence of postoperative complications. None of the patients in group 1 had local recurrence during 5 years. The locoregional-recurrence-free-survival (LRFS), metastasis-free survival and overall survival rates (86-100%, 70-49%, 80-64%) at 5 years were higher in groups with IORT compared to the control (32, 18, 25,5%). Rates of recurrence in group 3 (TCRT) didn’t differ significantly from the control during the first 4 years, moreover, the first year LRFS was even higher (p=0,05).
About the Authors
A. L. Zubarev
Medical Radiological Research Centre of the Russian Academy of Medical Science
Russian Federation
Russian Federation
G. T. Kudryavtseva
Medical Radiological Research Centre of the Russian Academy of Medical Science
Russian Federation
Russian Federation
A. A. Kurilchik
Medical Radiological Research Centre of the Russian Academy of Medical Science
Russian Federation
Russian Federation
O. K. Kurpeshev
Medical Radiological Research Centre of the Russian Academy of Medical Science
Russian Federation
Russian Federation
A. L. Starodubtsev
Medical Radiological Research Centre of the Russian Academy of Medical Science
Russian Federation
Russian Federation
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Review
For citations:
Zubarev A.L., Kudryavtseva G.T., Kurilchik A.A., Kurpeshev O.K., Starodubtsev A.L. The combined treatment oflocally advanced soft tissue. Sarcomas (STS). Bone and soft tissue sarcomas, tumors of the skin. 2010;(2):35-38. (In Russ.)
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