The combined treatment oflocally advanced soft tissue. Sarcomas (STS)
Abstract
115 patients with locally advanced STS treated in MRRC RAMS were analyzed. In group 1 were included 32 patients who received preoperative thermo-chemo-radiotherapy (TCRT) and surgery with intraoperative radiation therapy (IORT). The group 2 consisted of 31 patients treated with preoperative chemo-radiotherapy (CRT) followed by surgery with IORT. The group 3 included 22 patients received TCRT, without surgery. The control group consisted of 30 patients treated with surgery only. IORT didn’t increase an incidence of postoperative complications. None of the patients in group 1 had local recurrence during 5 years. The locoregional-recurrence-free-survival (LRFS), metastasis-free survival and overall survival rates (86-100%, 70-49%, 80-64%) at 5 years were higher in groups with IORT compared to the control (32, 18, 25,5%). Rates of recurrence in group 3 (TCRT) didn’t differ significantly from the control during the first 4 years, moreover, the first year LRFS was even higher (p=0,05).
About the Authors
A. L. Zubarev
Medical Radiological Research Centre of the Russian Academy of Medical Science
Russian Federation
Russian Federation
G. T. Kudryavtseva
Medical Radiological Research Centre of the Russian Academy of Medical Science
Russian Federation
Russian Federation
A. A. Kurilchik
Medical Radiological Research Centre of the Russian Academy of Medical Science
Russian Federation
Russian Federation
O. K. Kurpeshev
Medical Radiological Research Centre of the Russian Academy of Medical Science
Russian Federation
Russian Federation
A. L. Starodubtsev
Medical Radiological Research Centre of the Russian Academy of Medical Science
Russian Federation
Russian Federation
References
1. Atlas of tumor pathology. 3 Series. Fascicle 30. Tumors of the soft tissues. Bethesda, Maryland, 2001, p. 1-420.
2. Fletcher Ch.D.M., Unni K.K., Mertens F. (eds.) World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of Soft Tissue and Bone. Lyon: IARS press, 2002, р. 264-270.
3. Давыдов М.И., Аксель E.M. Статистика злокачественных новообразований в России и странах СНГ в 2004 г. Вестник Российского онкологического научного центра им. Н.Н. Блохина РАМН. 2006, т. 17, № 3 (приложение 1), с. 45-66.
4. Jemal A., Tiwari R.C., Murray Т. et al. Cancer statistics, 2004, CA Cancer J. Clin. 2004, v. 54, p. 8.
5. Курпешев O.K., Бердов Б.А. Результаты локальной гипертермии в онкологии. Рос. онкологии, журн. 1999, No. 2, с. 48-52.
6. Calvo F.A., Santos М., Azinovic I. Intraoperative radiotherapy: Literature Updating with overview of result presented at the 6-International Symposium of Intraoperative radiation therapy. Rays. 1998, v. 23, No. 3, p. 439-461.
7. Azinovic I., Monge R.M., Aristu J.J. et al. Intraoperative radiotherapy electron boost followed by moderate doses of external beam radiotherapy in resected soft-tissue sarcoma of the extremities. Radiother Oncol. 2003, v. 67 (3), p. 331-337.
8. Иванов C.M., Ткачёв С.И., Бохян Б.Ю. и соавт. Терморадиохимиотерапия неоперабельных сарком мягких тканей. Вопросы онкологии. 2005, т.51,№3, с. 350-354.
9. Therasse Р., Arbuck S.G., Eisenhauer Е.А. et al. New guidelines to evaluate the response to treatment in solid tumors. Journal of the National Cancer Institute. 2000, v. 92, No. 3, p. 205-216.
10. Kaplan E.L., Meier P. Nonparametric estimation from incomplete observations. J. Amer. Stat. Ass. 1958, v. 53, p. 457-481.
11. Киселёва E.C., ЕолдобенкоЕВ., Канаев E.B. и соавт. Лучевая терапия злокачественных опухолей. М., «Медицина». 1996, 464 с.
12. Алиев М.Д., Мехтиева Н.И., Бохян Б.Ю. Факторы прогноза сарком мягких тканей. Вопросы онкологии. 2005, т. 51, № 3, с. 288-299.
13. Ramanathan R.C., A’Hem R., Fisher C., Thomas J.M. Prognostic index for extremity soft tissue sarcomas with isolated local recurrence. Ann. Surg. Oncol. 2001, v. 8, p. 278-289.
14. Engellau J., Anderson H., Ridholm A. et al. Time dependence of prognostic factors for patients with soft tissue sarcoma: a Scandinavian Sarcoma Group Study of 338 malignant fibrous histiocytomas. Cancer (Philad.). 2004, v. 100, p. 2233-2239.
Review
For citations:
Zubarev A.L., Kudryavtseva G.T., Kurilchik A.A., Kurpeshev O.K., Starodubtsev A.L. The combined treatment oflocally advanced soft tissue. Sarcomas (STS). Bone and soft tissue sarcomas, tumors of the skin. 2010;(2):35-38. (In Russ.)
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