Molecular, biological and diagnostic features of Ewing sarcoma and undifferentiated small round cell sarcomas of bone and soft tissue
https://doi.org/10.17650/2070-9781-2021-13-1-24-31
Abstract
Ewing’s sarcoma is a highly malignant small round cell tumor with a unique rearrangement of the EWSR1 (FUS) gene with partners genes of ETS family. Tumors with Ewing's sarcoma morphological features lacking without specific EWSR1 rear-rangement called undifferentiated small round cell sarcomas of bone and soft tissue. This group includes: sarcomas with СIC gene rearrangement, sarcomas with BCOR gene rearrangement and sarcomas with EWSR1 (FUS) gene rearrangement with non-ETS gene-partner. Clinical, morphological and molecular genetic characteristics of these groups of tumors will be described below
About the Authors
K. Y. Sinichenkova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology, Ministry of Healh of Russia
Russian Federation
Russian Federation
1 Samory Mashela St., Moscow 117198
V. Y. Roschin
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology, Ministry of Healh of Russia
Russian Federation
Russian Federation
1 Samory Mashela St., Moscow 117198
A. E. Druy
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology, Ministry of Healh of Russia
Russian Federation
Russian Federation
1 Samory Mashela St., Moscow 117198
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Review
For citations:
Sinichenkova K.Y., Roschin V.Y., Druy A.E. Molecular, biological and diagnostic features of Ewing sarcoma and undifferentiated small round cell sarcomas of bone and soft tissue. Bone and soft tissue sarcomas, tumors of the skin. 2021;13(1):24-31. (In Russ.) https://doi.org/10.17650/2070-9781-2021-13-1-24-31
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