Молекулярно-биологические и диагностические особенности саркомы Юинга и группы недифференцированных мелкокруглоклеточных опухолей костей и мягких тканей

Саркома Юинга – высокозлокачественная мелкокруглоклеточная опухоль, обладающая уникальной перестройкой гена EWSR1 (FUS) с генами-партнерами семейства ETS. Опухоли, обладающие морфологическими характеристиками саркомы Юинга, но не имеющие патогномоничной перестройки, входят в группу недифференцированных мелкокруглоклеточных опухолей костей и мягких тканей, куда также относятся саркомы с перестройкой генов CIC, BCOR, EWSR1 (FUS) с другими генами, не являющимися членами семейства ETS. Ниже будут изложены клинико-морфологические и молекулярно-генетические особенности данных групп злокачественных новообразований.

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