Preview

Bone and soft tissue sarcomas, tumors of the skin

Advanced search

Rib graph bone grafting in the treatment of a patient with Ewing sarcoma of the pelvic bones

https://doi.org/10.17650/2219-4614-2025-17-3-76-82

Abstract

The Ewing sarcoma is one of the two most common bone tumors that occur during childhood and adolescence. This pathology in more than 50 % of cases occurs in the 2nd decade of life and is rare in adults older than 30 years. In men, the Ewing sarcoma develops more often (male-to-female ratio is 1.5:1). This disease is rare in Black patients and Asians. Ewing sarcoma usually occurs in the metaphysis or diaphysis of the long bones of the extremities. Lesions of the pelvic region, ribs and shoulder blades are less common. The most common foci of metastasis are the lungs, bones, and bone marrow.

The article describes a clinical case of treatment of a 12-year-old girl with Ewing sarcoma of the pelvic bones (chemotherapy with a surgical stage: single-stage bone grafting of the resected section of the pubic bone using a rib graft).

About the Authors

S. O.  Gunyakov
Moscow  Regional  Oncological  Dispensary;  State  Scientific  Center  of  the  Russian  Federation  – A. I.  Burnazyan  Federal Medical  Biophysical  Center,  Russian  Federal  Medical   and  Biological  Agency
Russian Federation

6  Karbysheva  St.,  Balashikha  143900

23  Marshala  Novikova  St.,  Moscow  123098



A. V.  Khizhnikov
Moscow  Regional  Oncological  Dispensary;  State  Scientific  Center  of  the  Russian  Federation  – A. I.  Burnazyan  Federal Medical  Biophysical  Center,  Russian  Federal  Medical   and  Biological  Agency; Russian  State  Social  University
Russian Federation

6  Karbysheva  St.,  Balashikha  143900

23  Marshala  Novikova  St.,  Moscow  123098

 Bld. 1,  4  Vil’gel’ma  Peaka  St.,  Moscow  119226



M.  Yu.  Rykov
Russian  State  Social  University; Russian  Research  Institute  of  Health
Russian Federation

Maxim Yurievich Rykov

Bld. 1,  4  Vil’gel’ma  Peaka  St.,  Moscow  119226

11  Dobrolyubova  St.,  Moscow  127254



References

1. Hamilton S.N., Carlson R., Hasan H. et al. Long-term outcomes and complications in pediatric Ewing sarcoma. Am J Clin Oncol 2017;40(4):423–8. DOI: 10.1097/COC.0000000000000176

2. Raciborska A., Bilska K., Rychlowska-Pruszynska M. et al. Internal hemipelvectomy in the management of pelvic Ewing sarcoma – are outcomes better than with radiation therapy? J Pediatr Surg 2014;49(10):1500–4. DOI: 10.1016/j.jpedsurg.2014.04.013

3. La T.H., Meyers P.A., Wexler L.H. et al. Radiation therapy for Ewing’s sarcoma: results from Memorial Sloan-Kettering in the modern era. Int J Radiat Oncol Biol Phys 2006;64(2):544–50. DOI: 10.1016/j.ijrobp.2005.07.299

4. Paulino A.C., Nguyen T.X., Mai W.Y. An analysis of primary site control and late effects according to local control modality in non-metastatic Ewing sarcoma. Pediatr Blood Cancer 2007;48(4):423–9. DOI: 10.1002/pbc.20754

5. Brown A.P., Fixsen J.A., Plowman P.N. Local control of Ewing’s sarcoma: an analysis of 67 patients. Br J Radiol 1987;60(711):261–8. DOI: 10.1259/0007-1285-60-711-261

6. Hesla A.C., Tsagozis P., Jebsen N. et al. Improved prognosis for patients with ewing sarcoma in the sacrum compared with the innominate bones: the Scandinavian Sarcoma Group Experience. J Bone Joint Surg Am 2016;98(3):199–210. DOI: 10.2106/JBJS.O.00362

7. Paulussen M., Ahrens S., Dunst J. et al. Localized Ewing tumor of bone: final results of the cooperative Ewing’s sarcoma study CESS 86. J Clin Oncol 2001;19(6):1818–29. DOI: 10.1200/JCO.2001.19.6.1818

8. McLean T.W., Hertel C., Young M.L. et al. Late events in pediatric patients with Ewing sarcoma/primitive neuroectodermal tumor of bone: the Dana–Farber Cancer Institute/Children’s Hospital experience. J Pediatr Hematol Oncol 1999;21(6):486–93.

9. Sinkovics J.G., Plager C., Ayala A.G. et al. Ewing sarcoma: its course and treatment in 50 adult patients. Oncology 1980;37(2):114–9. DOI: 10.1159/000225417

10. Gehan E.A., Nesbit M.E. Jr, Burgert E.O. Jr et al. Prognostic factors in children with Ewing’s sarcoma. Natl Cancer Inst Monogr 1981;56:273–8.

11. Thomas I.H., Cole W.G., Waters K.D., Menelaus M.B. Function after partial pelvic resection for Ewing’s sarcoma. J Bone Joint Surg Br 1987;69(2):271–5. DOI: 10.1302/0301-620X.69B2.3818759

12. De Santis E., Rossetti D., Pallotta F., Pannone A. Current trends in the treatment of Ewing’s sarcoma. Ital J Orthop Traumatol 1988;14(1):49–58.

13. Evans R., Nesbit M., Askin F. et al. Local recurrence, rate and sites of metastases, and time to relapse as a function of treatment regimen, size of primary and surgical history in 62 patients presenting with non-metastatic Ewing’s sarcoma of the pelvic bones. Int J Radiat Oncol Biol Phys 1985;11(1):129–36. DOI: 10.1016/0360-3016(85)90371-2

14. Rosen G., Caparros B., Nirenberg A. et al. Ewing’s sarcoma: ten-year experience with adjuvant chemotherapy. Cancer 1981;47(9):2204–13. DOI: 10.1002/1097-0142(19810501)47:9<2204::aid-cncr2820470916>3.0.co;2-a

15. Wilkins R.M., Pritchard D.J., Burgert E.O. Jr, Unni K.K. Ewing’s sarcoma of bone. Experience with 140 patients. Cancer 1986;58(11):2551–5. DOI: 10.1002/1097-0142(19861201)58:11<2551::aid-cncr2820581132>3.0.co;2-y

16. Capanna R., Toni A., Sudanese A. et al. Ewing’s sarcoma of the pelvis. Int Orthop 1990;14(1):57–61. DOI: 10.1007/BF00183366

17. Scully S.P., Temple H.T., O’Keefe R.J. et al. Role of surgical resection in pelvic Ewing’s sarcoma. J Clin Oncol 1995;13(9):2336–41. DOI: 10.1200/JCO.1995.13.9.2336

18. Indelicato D.J., Keole S.R., Shahlaee A.H. et al. Impact of local management on long-term outcomes in Ewing tumors of the pelvis and sacral bones: the University of Florida experience. Int J Radiat Oncol Biol Phys 2008;72(1):41–8. DOI: 10.1016/j.ijrobp.2007.12.014

19. Jawad M.U., Haleem A.A., Scully S.P. Malignant sarcoma of the pelvic bones: treatment outcomes and prognostic factors vary by histopathology. Cancer 2011;117(7):1529–41. DOI: 10.1002/cncr.25684

20. Hoffmann C., Ahrens S., Dunst J. et al. Pelvic Ewing sarcoma: a retrospective analysis of 241 cases. Cancer 1999;85(4):869–77. DOI: 10.1002/(sici)1097-0142(19990215)85:4<869::aid-cncr14>3.0.co;2-8

21. Foulon S., Brennan B., Gaspar N. et al. Can postoperative radiotherapy be omitted in localised standard-risk Ewing sarcoma? An observational study of the Euro-E.W.I.N.G group. Eur J Cancer 2016;61:128–36. DOI: 10.1016/j.ejca.2016.03.075

22. Whelan J., Hackshaw A., McTiernan A. et al. Survival is influenced by approaches to local treatment of Ewing sarcoma within an international randomised controlled trial: analysis of EICESS-92. Clin Sarcoma Res 2018;8:6. DOI: 10.1186/s13569-018-0093-y.

23. Andreou D., Ranft A., Gosheger G. et al. Which factors are associated with local control and survival of patients with localized pelvic Ewing’s sarcoma? A retrospective analysis of data from the Euro-EWING99 Trial. Clin Orthop Relat Res 2020;478(2):290–302. DOI: 10.1097/CORR.0000000000000962

24. Guder W.K., Hardes J., Nottrott M. et al. Pelvic Ewing sarcoma: a retrospective outcome analysis of 104 patients who underwent pelvic tumor resection at a single supra-regional center. J Orthop Surg Res 2020;15(1):534. DOI: 10.1186/s13018-020-02028-3

25. Anderton J., Moroz V., Marec-Bérard P. et al. International randomised controlled trial for the treatment of newly diagnosed EWING sarcoma family of tumours – EURO EWING 2012 Protocol. Trials 2020;21(1):96. DOI: 10.1186/s13063-019-4026-8


Review

For citations:


Gunyakov S.O.,  Khizhnikov A.V., Rykov M.Yu. Rib graph bone grafting in the treatment of a patient with Ewing sarcoma of the pelvic bones. Bone and soft tissue sarcomas, tumors of the skin. 2025;17(3):76-82. (In Russ.) https://doi.org/10.17650/2219-4614-2025-17-3-76-82

Views: 130


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2219-4614 (Print)
ISSN 2782-3687 (Online)