Брахитератия при саркомах мягких тканей (обзор литературы)
Д. А. Буров,
Д. И. Федосеенко,
Н. С. Петроченко,
О. В. Козлов,
А. Г. Сальков,
Б. Ю. Бохян,
М. В. Черных,
А. К. Валиев https://doi.org/10.17650/2219-4614-2024-16-4-43-52
Аннотация
В статье представлен анализ публикаций, посвященных эффективности брахитерапии при саркомах мягких тканей. Показано, что этот метод представляет собой важную часть комбинированного лечения данной патологии, а показания к его применению постоянно расширяются. Авторы указывают на высокий уровень локального контроля над заболеванием (от 50 до 96 % случаев). Наибольшая эффективность брахитерапии наблюдается в комбинации с хирургическим удалением опухоли.
Ключевые слова
При поддержке: Работа выполнена при финансовой поддержке Российского научного фонда (грант № 23-65-00003).
Об авторах
Д. А. Буров
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России
Россия
Россия
Денис Александрович Буров
115522 Москва, Каширское шоссе, 24
Д. И. Федосеенко
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России
Россия
Россия
115522 Москва, Каширское шоссе, 24
Н. С. Петроченко
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России
Россия
Россия
115522 Москва, Каширское шоссе, 24
О. В. Козлов
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России
Россия
Россия
115522 Москва, Каширское шоссе, 24
А. Г. Сальков
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России
Россия
Россия
115522 Москва, Каширское шоссе, 24
Б. Ю. Бохян
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России
Россия
Россия
115522 Москва, Каширское шоссе, 24
М. В. Черных
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России
Россия
Россия
115522 Москва, Каширское шоссе, 24
А. К. Валиев
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России
Россия
Россия
115522 Москва, Каширское шоссе, 24
Список литературы
1. Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual data. Lancet 1997;350(9092): 1647–54.
2. Alekhteyar K.M., Leung D.H., Brennan M.F., Harrison L.B. The effect of combined external beam radiotherapy and brachytherapy on local control and wound complications in patients with high-grade soft tissue sarcomas of the extremity with positive microscopic margin. Int J Radiat Oncol Biol Phys 1996;36(2):321–4. DOI: 10.1016/s0360-3016(96)00331-8
3. Alektiar K.M., Brennan M.F., Singer S. Local control comparison of adjuvant brachytherapy to intensity-modulated radiotherapy in primary high-grade sarcoma of the extremity. Cancer 2011;117(14):3229–34. DOI: 10.1002/cncr.25882
4. Guzik G., Łyczek J., Kowalik Ł. Surgical resection with adjuvant brachytherapy in soft tissue sarcoma of the extremity – a case report. J Contemp Brachyther 2012;4(4):227–31. DOI: 10.5114/jcb.2012.32557
5. Lawrenz J.M., Johnson S.R., Zhu K. et al. Adjuvant radiation after primary resection of atypical lipomatous tumors of the extremity reduces local recurrence but increases complications: a multicenter evaluation. Sarcoma 2022;2022:2091677. DOI: 10.1155/2022/2091677
6. Manir K.S., Basu A., Choudhury K.B. et al. Interstitial brachytherapy in soft tissue sarcoma: a 5 years institutional experience with cobalt 60-based high-dose-rate brachytherapy system. J Contemp Brachyther 2018;10(5):431–8. DOI: 10.5114/jcb.2018.78994
7. Muhic A., Hovgaard D., Mørk Petersen M. et al. Local control and survival in patients with soft tissue sarcomas treated with limb sparing surgery in combination with interstitial brachytherapy and external radiation. Radiother Oncol 2008;88(3):382–7. DOI: 10.1016/j.radonc.2008.06.002
8. Roeder F. Radiation therapy in adult soft tissue sarcoma – current knowledge and future directions: a review and expert opinion. Cancers 2020;12(11):3242. DOI: 10.3390/cancers12113242
9. Strohmaier S., Zwierzchowski G. Comparison of (60) Co and (192) Ir sources in HDR brachytherapy. J Contemp Brachytherapy 2011;4: 199–208. DOI: 10.5114/jcb.2011.26471
10. Abarca T., Gao Y., Monga V. et al. Improved survival for extremity soft tissue sarcoma treated in high-volume facilities. J Surg Oncol 2018;117(7):1479–86. DOI: 10.1002/jso.25052
11. Emory C.L., Montgomery C.O., Potter B.K. et al. Early complications of high-dose-rate brachytherapy in soft tissue sarcoma: a comparison with traditional external-beam radiotherapy. Clin Orthop Relat Res 2012;470(3):751–8. DOI: 10.1007/s11999-011-2106-5
12. Casali P.G., Jost L., Sleijfer S. et al. Soft Tissue sarcomas: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol 2008;19(Suppl. 2):ii89–93. DOI: 10.1093/annonc/mdn101
13. DeLaney T.F., Trofimov A.V., Engelsman M., Suit H.D. Advanced-technology radiation therapy in the management of bone and soft tissue sarcomas. Cancer Control 2005;12(1):27–35. DOI: 10.1177/107327480501200104
14. Ghadimi M.P.H., Rehders A., Knoefel W.T. Multimodal management in soft tissue sarcoma of the trunk and extremities. Chirurg 2014;85(5):378–82. DOI: 10.1007/s00104-013-2690-x
15. Martínez-Monge R., San Julián M., Amillo S. et al. Perioperative highdose-rate brachytherapy in soft tissue sarcomas of the extremity and superficial trunk in adults: initial results of a pilot study. Brachytherapy 2005;4(4):264–70. DOI: 10.1016/j.brachy.2005.06.003
16. Gimeno M., San Julián M., Cambeiro M. et al. Long-term results of perioperative high dose rate brachytherapy (PHDRB) and external beam radiation in adult patients with soft tissue sarcomas of the extremities and the superficial trunk: final results of a prospective controlled study. Radiother Oncol 2019;135:91–9. DOI: 10.1016/j.radonc.2019.02.011
17. Mariani L., Miceli R., Kattan M.W. et al. Validation and adaptation of a nomogram for predicting the survival of patients with extremity soft tissue sarcoma using a three-grade system. Cancer 2005;103(2):402–8. DOI: 10.1002/cncr.20778
18. Miller E.D., Xu-Welliver M., Haglund K.E. The role of modern radiation therapy in the management of extremity sarcomas. J Surg Oncol 2015;111(5):599–603. DOI: 10.1002/jso.23823
19. Burningham Z., Hashibe M., Spector L., Schiffman J.D. The epidemiology of sarcoma. Clin Sarcoma Res 2012;2(1):14. DOI: 10.1186/2045-3329-2-14
20. Fontanesi J., Mott M.P., Lucas D.R. et al. The role of irradiation in the management of locally recurrent non-metastatic soft tissue sarcoma of extremity/trunkal locations. Sarcoma 2004;8(2–3):57–61. DOI: 10.1080/13577140412331332785
21. Klein J., Ghasem A., Huntley S. et al. Does an algorithmic approach to using brachytherapy and external beam radiation result in good function, local control rates, and low morbidity in patients with extremity soft tissue sarcoma? Clin Orthop Relat Res 2018;476(3):634–44. DOI: 10.1007/s11999.0000000000000079
22. Roeder F., Lehner B., Saleh-Ebrahimi L. et al. Intraoperative electron radiation therapy combined with external beam radiation therapy and limb sparing surgery in extremity soft tissue sarcoma: a retrospective single center analysis of 183 cases. Radiother Oncol 2016;119(1):22–9. DOI: 10.1016/j.radonc.2015.11.014
23. Maples W.J., Buskirk S.J. Multimodality treatment of upper extremity bone and soft tissue sarcomas. Hand Clin 2004;20(2):221–5. DOI: 10.1016/j.hcl.2004.03.021
24. Цховребов Е.Е., Богдаев Ю.М., Суслова В.А. Брахитерапия в комплексном лечении сарком мягких тканей. Диагностическая и интервенционная радиология 12(2 Приложение № 1);21–2.
25. Arifi S., Belbaraka R., Rahhali R., Ismaili N. Treatment of adult soft tissue sarcomas: an overview. Rare Cancers Ther 2015;3(1):69–87. DOI: 10.1007/s40487-015-0011-x
26. Laskar S., Bahl G., Puri A. et al. Perioperative interstitial brachytherapy for soft tissue sarcomas: prognostic factors and long-term results of 155 patients. Ann Surg Oncol 2007;14(2):560–7. DOI: 10.1245/s10434-006-9137-2
27. Aronowitz J.N., Pohar S.S., Liu L. et al. Adjuvant high dose rate brachytherapy in the management of soft tissue sarcoma: a dose-toxicity analysis. Am J Clin. Oncol 2006;29(5):508–13. DOI: 10.1097/01.coc.0000231433.97407.c8
28. Daigeler A., Zmarsly I., Hirsch T. et al. Long-term outcome after local recurrence of soft tissue sarcoma: a retrospective analysis of factors predictive of survival in 135 patients with locally recurrent soft tissue sarcoma. Br J Cancer 2014;110(6):1456–64. DOI: 10.1038/bjc.2014.21
29. Fontanesi J., Mott M.P., Kraut M.J. et al. The role of postoperative irradiation in the treatment of locally recurrent incompletely resected extra-abdominal desmoid tumors. Sarcoma 2004;8(2–3):83–6. DOI: 10.1080/13577140410001710512
30. Larrier N.A., Czito B.G., Kirsch D.G. Radiation therapy for soft tissue sarcoma: indications and controversies for neoadjuvant therapy, adjuvant therapy, intraoperative radiation therapy, and brachytherapy. Surg Oncol Clin N Am 2016;25(4):841–60. DOI: 10.1016/j.soc.2016.05.012
31. Pasquali S., Palassini E., Stacchiotti S. et al. Neoadjuvant treatment: a novel standard? Curr Opin Oncol 2017;29(4):253–9. DOI: 10.1097/CCO.0000000000000372
32. Röper B., Heinrich C., Kehl V. et al. Study of preoperative radiotherapy for sarcomas of the extremities with intensity-modulation, imagguidance and small safety-margins (PREMISS). BMC Cancer 2015;15:904. DOI: 10.1186/s12885-015-1633-y
33. Spoto R., Vavassori A., Dicuonzo S. et al. Adjuvant radiotherapy treatment for soft tissue sarcoma of extremities and trunk. A retrospective mono-institutional analysis. Neoplasma 2020;67(6):1447–55. DOI: 10.4149/neo_2020_200325N305
34. Llacer C., Delannes M., Minsat M. et al. Low-dose intraoperative brachytherapy in soft tissue sarcomas involving neurovascular structure. Radiother Oncol 2006;78(1):10–6. DOI: 10.1016/j.radonc.2005.12.002
35. Naghavi A.O., Fernandez D.C., Mesko N. et al. American brachytherapy society consensus statement for soft tissue sarcoma brachytherapy. Brachytherapy 2017;16(3):466–89. DOI: 10.1016/j.brachy.2017.02.004
36. Alektiar K.M., Leung D., Zelefsky M.J. et al. Adjuvant brachytherapy for primary high-grade soft tissue sarcoma of the extremity. Ann Surg Oncol 2002;9(1):48–56. DOI: 10.1245/aso.2002.9.1.48
37. Beltrami G., Rüdiger H.A., Mela M.M. et al. Limb salvage surgery in combination with brachytherapy and external beam radiation for high-grade soft tissue sarcomas. Eur J Surg Oncol 2008;34(7):811–6. DOI: 10.1016/j.ejso.2007.08.011
38. Cortesi A., Galuppi A., Frakulli R. et al. Adjuvant radiotherapy with brachytherapy boost in soft tissue sarcomas. J Contemp Brachyther 2017;9(3):256–62. DOI: 10.5114/jcb.2017.68215
39. Kaushal A., Citrin D. The role of radiation therapy in the management of sarcomas. Surg Clin N Am 2008;88(3):629–46. DOI: 10.1016/j.suc.2008.03.005
40. Lazzaro G., Lazzari R., Pelosi G. et al. Pulsed dose-rate perioperative interstitial brachytherapy for soft tissue sarcomas of the extremities and skeletal muscles of the trunk. Ann Surg Oncol 2005;12(11):935–42. DOI: 10.1245/ASO.2005.11.004
41. Nandra R., Hwang N., Matharu G. et al. One-year mortality in patients with bone and soft tissue sarcomas as an indicator of delay in presentation. Ann R Coll Surg Engl 2015;97(6):425–33. DOI: 10.1308/003588415X14181254790284
42. Potter J.W., Jones K.B., Barrott J.J. Sarcoma – the standard-bearer in cancer discovery. Crit Rev Oncol Hematol 2018;126:1–5. DOI: 10.1016/j.critrevonc.2018.03.007
43. Alektiar K.M., Zelefsky M.J., Brennan M.F. Morbidity of adjuvant brachytherapy in soft tissue sarcoma of the extremity and superficial trunk. Int J Radiat Oncol Biol Phys 2000;47(5):1273–9. DOI: 10.1016/s0360-3016(00)00587-3
44. Correa R., Gómez-Millán J., Lobato M. et al. Radiotherapy in soft-tissue sarcoma of the extremities. Clin Transl Oncol 2018;20(9):1127–35. DOI: 10.1007/s12094-018-1848-x
45. Kretzler A., Molls M., Gradinger R. et al. Intraoperative radiotherapy of soft tissue sarcoma of the extremity. Strahlenther Onkol 2004;180(6):365–70. DOI: 10.1007/s00066-004-1191-8
46. Moureau-Zabotto L., Thomas L., Bui B.N. et al. Management of soft tissue sarcomas (STS) in first isolated local recurrence: a retrospective study of 83 cases. Radiother Oncol 2004;73(3):313–9. DOI: 10.1016/j.radonc.2004.05.008
47. Naghavi A.O., Gonzalez R.J., Scott J.G. et al. Implications of staged reconstruction and adjuvant brachytherapy in the treatment of recurrent soft tissue sarcoma. Brachytherapy 2016;15(4):495–503. DOI: 10.1016/j.brachy.2016.03.013
48. Delaney T.F. Radiation therapy: neoadjuvant, adjuvant, or not at all. Surg Oncol Clin N Am 2012;21(2):215–41. DOI: 10.1016/j.soc.2011.12.005
49. Sarria G.R., Petrova V., Wenz F. et al. Intraoperative radiotherapy with low energy x-rays for primary and recurrent soft-tissue sarcomas. Radiat Oncol 2020;15(1):110. DOI: 10.1186/s13014-020-01559-7
50. Bradley J.A., Kleinman S.H., Rownd J. et al. Adjuvant high dose rate brachytherapy for soft tissue sarcomas: initial experience report. J Contemp Brachyther 2011;3(1):3–10. DOI: 10.5114/jcb.2011.21036
51. Shukla N.K., Deo S.V.S. Soft tissue sarcoma – review of experience at a tertiary care cancer centre. Indian J Surg Oncol 2011;2(4):309–12. DOI: 10.1007/s13193-011-0119-x
52. Healey J.H. CORR insights®: does an algorithmic approach to using brachytherapy and external beam radiation result in good function, local control rates, and low morbidity in patients with extremity soft tissue sarcoma? Clin Orthop Relat Res 2018;476(3):645–7. DOI: 10.1007/s11999.0000000000000184
53. Ren C., Shi R., Min L. et al. Experience of interstitial permanent i125 brachytherapy for extremity soft tissue sarcomas. Clin Oncol 2014;26(4):230–5. DOI: 10.1016/j.clon.2014.01.004
54. Torres M.A., Ballo M.T., Butler C.E. et al. Management of locally recurrent soft-tissue sarcoma after prior surgery and radiation therapy. Int J Radiat Oncol Biol Phys 2007;67(4):1124–9. DOI: 10.1016/j.ijrobp.2006.10.036
55. Kattan M.W., Leung D.H.Y., Brennan M.F. Postoperative nomogram for 12-year sarcoma-specific death. JCO 2002;20(3):791–6. DOI: 10.1200/JCO.2002.20.3.791
56. San Miguel I., San Julian M., Cambeiro M. et al. Determinants of toxicity, patterns of failure, and outcome among adult patients with soft tissue sarcomas of the extremity and superficial trunk treated with greater than conventional doses of perioperative high-doserate brachytherapy and external beam radiotherapy. Int J Radiat Oncol Biol Phys 2011;81(4):529–39. DOI: 10.1016/j.ijrobp.2011.04.063
57. Atean I., Pointreau Y., Rosset P. et al. Prognostic factors of extremity soft tissue sarcoma in adults. A single institutional analysis. Cancer Radiother 2012;16(8):661–6. DOI: 10.1016/j.canrad.2012.05.021
58. Mierzwa L.M., McCluskey C.M., Barrett W.L. et al. Interstitial brachytherapy for soft tissue sarcoma: a single institution experience. Brachytherapy 2007;6(4):298–303. DOI: 10.1016/j.brachy.2007.08.004
59. Alektiar K.M., Hong, L., Brennan M.F. et al. Intensity modulated radiation therapy for primary soft tissue sarcoma of the extremity: preliminary results. Int J Radiat Oncol Biol Phys 2007;68(2):458–64. DOI: 10.1016/j.ijrobp.2006.12.054
60. Rimner A., Brennan M.F., Zhang Z. et al. Influence of compartmental involvement on the patterns of morbidity in soft tissue sarcoma of the thigh. Cancer 2009;115(1):149–57. DOI: 10.1002/cncr.23975
61. Rudert M., Burgkart R., Gradinger R., Rechl H. Surgical treatment of musculoskeletal soft tissue sarcomas. Chirurg 2009;80(3):194–201. DOI: 10.1007/s00104-008-1595-6
62. Mukherji A., Sinnatamby M. Malignant soft tissue sarcoma of the shoulder treated by surface mould brachytherapy boost in an adjuvant setting. J Contemp Brachyther 2017;9(2):167–73. DOI: 10.5114/jcb.2017.67392
63. Petera J., Soumarová R., Růzicková J. et al. Perioperative hyperfractionated high-dose rate brachytherapy for the treatment of soft tissue sarcomas: multicentric experience. Ann Surg Oncol 2010;17(1):206–10. DOI: 10.1245/s10434-009-0684-1
64. Murray P.M. Soft tissue sarcoma of the upper extremity. Hand Clin 2004;20(3):325–33. DOI: 10.1016/j.hcl.2004.03.007
65. Vavassori A., Pennacchioli E., Augugliaro M. et al. Adjuvant high-dose-rate interstitial brachytherapy for malignant peripheral nerve sheath tumor of the foot: a case report. J Contemp Brachyther 2021;13(3):338–46. DOI: 10.5114/jcb.2021.106204
66. Baumert B.G., Infanger M., Reiner B., Davis J.B. A novel technique using customised templates for the application of fractionated interstitial HDR brachytherapy to the tumour bed in soft-tissue sarcomas located in the extremities. Clin Oncol 2004;16(7):457–60. DOI: 10.1016/j.clon.2004.06.020
67. Rachbauer F., Sztankay A., Kreczy A. et al. High-dose-rate intraoperative brachytherapy (IOHDR) using flab technique in the treatment of soft tissue sarcomas. Strahlenther Onkol 2003;179(7):480–5. DOI: 10.1007/s00066-003-1063-7
68. Schuetze M.S., Ray M.E. Adjuvant therapy for soft tissue sarcoma. J Natl Compr Cancer Netw 2005;3(2):207–13. DOI: 10.6004/jnccn.2005.0013
69. Schneider F., Clausen S., Thölking J. et al. A novel approach for superficial intraoperative radiotherapy (IORT) using a 50 KV x-ray source: a technical and case report. J Appl Clin Med Phys 2014;15(1):167–76. DOI: 10.1120/jacmp.v15i1.4502
70. Ballo M.T., Lee A.K. current results of brachytherapy for soft tissue sarcoma. Curr Opin Oncol 2003;15(4):313–8. DOI: 10.1097/00001622-200307000-00006
71. Roeder F., Krempien R. Intraoperative radiation therapy (IORT) in soft-tissue sarcoma. Radiat Oncol 2017;12(1):20. DOI: 10.1186/s13014-016-0751-2
72. Mccarter M.D., Jaques D.P., Brennan M.F. Randomized clinical trials in soft tissue sarcoma. Surg Oncol Clin N Am 2002;11(1):11–22. DOI: 10.1016/s1055-3207(03)00073-5
Рецензия
Для цитирования:
Буров Д.А., Федосеенко Д.И., Петроченко Н.С., Козлов О.В., Сальков А.Г., Бохян Б.Ю., Черных М.В., Валиев А.К. Брахитератия при саркомах мягких тканей (обзор литературы). Саркомы костей, мягких тканей и опухоли кожи. 2024;16(4):43-52. https://doi.org/10.17650/2219-4614-2024-16-4-43-52
For citation:
Burov D.A., Fedoseenko D.I., Petrochenko N.S., Kozlov O.V., Salkov A.G., Bokhyan B.Yu., Chernykh M.V., Valiev A.K. Brachytherapy in soft tissue sarcomas (literature review). Bone and soft tissue sarcomas, tumors of the skin. 2024;16(4):43-52. (In Russ.) https://doi.org/10.17650/2219-4614-2024-16-4-43-52
Просмотров:
721
Послать статью по эл. почте 
