Rare case of primary cardiac osteosarcoma
A. D. Darenskaya,
B. M. Medvedeva,
O. A. Anurova,
O. V. Romanova,
E. I. Borisova,
A. Yu. Kashcheeva,
S. L. Gutorov https://doi.org/10.17650/2219-4614-2024-16-3-71-80
Abstract
Primary cardiac osteosarcoma is an extremely rare malignant tumor, its incidence is less than 10 % of all primary cardiac sarcomas. Currently, less than 100 cases of this disease have been reported, and there is no consensus on the optimal approaches to treatment. The article presents a clinical case of primary cardiac osteosarcoma noting the effectiveness of two chemotherapy lines and describes difficulties in tumor morphology interpretation.
About the Authors
A. D. Darenskaya
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Anna Dmitrievna Darenskaya
24 Kashirskoe Shosse, Moscow 115522
B. M. Medvedeva
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
O. A. Anurova
V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Russian Federation
Russian Federation
4 Akademika Oparina St., Moscow 117997
O. V. Romanova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
E. I. Borisova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
A. Yu. Kashcheeva
Sechenov University, Ministry of Health of Russia
Russian Federation
Russian Federation
Bld. 2, 8 Trubetskaya St., Moscow 119048
S. L. Gutorov
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
References
1. Patel J., Sheppard M.N. Pathological study of primary cardiac and pericardial tumours in a specialist UK Centre: surgical and autopsy series. Cardiovasc Pathol 2010;19(6):343–52. DOI: 10.1016/j.carpath.2009.07.005
2. Lam K.Y., Dickens P., Chan A.C. Tumors of the heart. A 20-year experience with a review of 12,485 consecutive autopsies. Arch Pathol Lab Med 1993;117(10):1027–31.
3. Travis W.D., Brambilla E., Burke A.P. et al. WHO classification of tumours of the lung, pleura, thymus and heart. 4th edn. Lyon: International Agency for Research on Cancer, 2015.
4. Burke A., Tavora F. The 2015 WHO classification of tumors of the heart and pericardium. J Thorac Oncol 2016;11(4):441–52. DOI: 10.1016/j.jtho.2015.11.009
5. Putnam J.B. Jr, Sweeney M.S., Colon R. et al. Primary cardiac sarcomas. Ann Thorac Surg 1991;51(6):906–10. DOI: 10.1016/0003-4975(91)91003-e
6. Burke A.P., Cowan D., Virmani R. Primary sarcomas of the heart. Cancer 1992;69(2):387–95. DOI: 10.1002/1097-0142(19920115)69:2<387::aidcncr2820690219>3.0.co;2-n
7. Hamidi M., Moody J.S., Weigel T.L., Kozak K.R. Primary cardiac sarcoma. Ann Thorac Surg 2010;90(1):176–81. DOI: 10.1016/j.athoracsur.2010.03.065
8. Agaimy A., Rösch J., Weyand M., Strecker T. Primary and metastatic cardiac sarcomas: a 12-year experience at a German heart center. Int J Clin Exp Pathol 2012;5(9):928–38.
9. Wang J.G., Liu B., Gao H. et al. Primary cardiac osteosarcoma. Heart Lung Circ 2016;25(7):698–704. DOI: 10.1016/j.hlc.2016.01.006
10. Aguilar C.A., Donet J.A., Galarreta C.I., Yabar A. A primary cardiac osteosarcoma: Case report and review of the literature. J Cardiol Cases 2012;7(2):e29–33. DOI: 10.1016/j.jccase.2012.09.010
11. Mhadgut H., Manthri S., Youssef B., Jaishankar D. The rarest of the rare: a case of primary cardiac osteosarcoma with a review of the literature. Cureus 2021;13(7):e16492. DOI: 10.7759/cureus.16492
12. Chen R., Xu Y., Zhu Y. Primary left atrium osteosarcoma with extensive ossification: a case report. Radiol Case Rep 2023;18(11):3844–8. DOI: 10.1016/j.radcr.2023.08.017
13. Karagöz Özen D.S., Oztürk M.A., Selcukbiricik F. et al. Primary osteosarcoma of the heart: experience of an unusual case. Case Rep Oncol 2013;6(1):224–8. DOI: 10.1159/000351123
14. Luo H., Lei Y., Su C. et al. Primary cardiac osteosarcoma in a 42-year-old woman. J Cardiothorac Surg 2010;5:120. DOI: 10.1186/1749-8090-5-120
15. Takeuchi I., Kawaguchi T., Kimura Y. et al. Primary cardiac osteosarcoma in a young man with severe congestive heart failure. Intern Med 2007;46(10):649–51. DOI: 10.2169/internalmedicine.46.6267
16. Mozafari R., Mohebbi Z., Shooshtarizadeh T., Sotoude H. Primary cardiac osteosarcoma: A rare cause of chest pain in a young man. Indian J Cancer 2019;56(1):86–7. DOI: 10.4103/ijc.IJC_259_18
17. Koçak H., Karapolat S., Gündogdu C. et al. Primary cardiac osteosarcoma in a pregnant woman. Heart Vessels 2006;21(1):56–8. DOI: 10.1007/s00380-005-0830-z
18. Bae D.H., Park S., Kim M. et al. Cardiac osteosarcoma: a case report and literature review. Front Cardiovasc Med 2023;10:1215389. DOI: 10.3389/fcvm.2023.1215389
19. Dell’Amore A., Asadi N., Caroli G. et al. Recurrent primary cardiac osteosarcoma: a case report and literature review. Gen Thorac Cardiovasc Surg 2014;62(3):175–80. DOI: 10.1007/s11748-013-0236-2
20. Li Y., Ye T., Gu Q. et al. Primary, cardiac, fibroblastic osteosarcoma: a case report. Medicine (Baltimore) 2018;97(1):e9543. DOI: 10.1097/MD.0000000000009543
21. Seidal T., Wandt B., Lundin S.E. Primary chondroblastic osteogenic sarcoma of the left atrium. Case report. Scand J Thorac Cardiovasc Surg 1992;26(3):233–6. DOI: 10.3109/14017439209099084
22. Zanella M., Falconieri G., Bussani R. et al. Polypoid osteosarcoma of the left atrium: report of a new case with autopsy confirmation and review of the literature. Ann Diagn Pathol 1998;2(3):167–72. DOI: 10.1016/s1092-9134(98)80004-x
23. Moeri-Schimmel R., Pras E., Desar I. et al. Primary sarcoma of the heart: case report and literature review. J Cardiothorac Surg 2020;15(1):104. DOI: 10.1186/s13019-020-01157-4
24. Devbhandari M.P., Meraj S., Jones M.T. et al. Primary cardiac sarcoma: reports of two cases and a review of current literature. J Cardiothorac Surg 2007;2:34. DOI: 10.1186/1749-8090-2-34
25. Cumming A.R., Shillitoe A.J. Ballvalve mitral obstruction by a sarcoma of a pulmonary vein. Br Heart J 1957;19(2):287–9. DOI: 10.1136/hrt.19.2.287
26. Ye Z., Shi H., Peng T., Han A. Clinical and pathological features of high grade primary cardiac osteosarcoma. Interact Cardiovasc Thorac Surg 2011;12(1):94–5. DOI: 10.1510/icvts.2010.249300
27. Nowrangi S.K., Ammash N.M., Edwards W.D. et al. Calcified left ventricular mass: unusual clinical, echocardiographic, and computed tomographic findings of primary cardiac osteosarcoma. Mayo Clin Proc 2000;75(7):743–7. DOI: 10.4065/75.7.743
28. Zhang L., Ellis J., Kumar D., Deng T. Primary right ventricular osteosarcoma. Can J Cardiol 2008;24(3):225–6. DOI: 10.1016/s0828-282x(08)70590-7
29. Sogabe O., Ohya T. Right ventricular failure due to primary right ventricle osteosarcoma. Gen Thorac Cardiovasc Surg 2007;55(1):19–22. DOI: 10.1007/s11748-006-0053-y
30. Forslund T., Melin J., Seppä A. Primary osteosarcoma of the right heart ventricle and atrium; a case report. Clin Med Oncol 2008;2:43–6. DOI: 10.4137/cmo.s541
31. Lurito K.J., Martin T., Cordes T. Right atrial primary cardiac osteosarcoma. Pediatr Cardiol 2002;23(4):462–5. DOI: 10.1007/s00246-002-0151-2
32. Dohi T., Ohmura H., Daida H., Amano A. Primary right atrial cardiac osteosarcoma with congestive heart failure. Eur J Cardiothorac Surg 2009;35(3):544–6. DOI: 10.1016/j.ejcts.2008.12.009
33. Chan E.Y., Ali A., Zubair M.M. et al. Primary cardiac sarcomas: Treatment strategies. J Thorac Cardiovasc Surg 2023;166(3): 828–38.e2. DOI: 10.1016/j.jtcvs.2021.10.070
34. Zhang P.J., Brooks J.S., Goldblum J.R. et al. Primary cardiac sarcomas: a clinicopathologic analysis of a series with follow-up information in 17 patients and emphasis on long-term survival. Hum Pathol 2008;39(9):1385–95. DOI: 10.1016/j.humpath.2008.01.019
35. Simpson L., Kumar S.K., Okuno S.H. et al. Malignant primary cardiac tumors: review of a single institution experience. Cancer 2008;112(11):2440–6. DOI: 10.1002/cncr.234
Review
For citations:
Darenskaya A.D., Medvedeva B.M., Anurova O.A., Romanova O.V., Borisova E.I., Kashcheeva A.Yu., Gutorov S.L. Rare case of primary cardiac osteosarcoma. Bone and soft tissue sarcomas, tumors of the skin. 2024;16(3):71-80. (In Russ.) https://doi.org/10.17650/2219-4614-2024-16-3-71-80
Views:
1430
Email this article 
