Preview

Bone and soft tissue sarcomas, tumors of the skin

Advanced search

Diagnostic and treatment of secondary chondrosarcoma of the femur with multiple recurrences. Case report

https://doi.org/10.17650/2782-3687-2022-14-2-52-60

Abstract

Chondrosarcoma is one of the most common tumors in adults. Resectable chondrosarcomas requires surgical treatment, and tend to local recurrence, often repeatedly.
A case report of a 38 years old female patient with secondary chondrosarcoma of femur is presented. The role of multidisciplinary team in tactic choice of primary treatment and recurrence treatment is shown.

About the Authors

A. V. Fedorova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

Alexandra Vladimirovna Fedorova

24 Kashirskoe Shosse, Moscow 115478



E. A. Sushentsov
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

24 Kashirskoe Shosse, Moscow 115478



D. K. Agaev
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

24 Kashirskoe Shosse, Moscow 115478



N. V. Kochergina
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

24 Kashirskoe Shosse, Moscow 115478



A. B. Bludov
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

24 Kashirskoe Shosse, Moscow 115478



Y. A. Shchipakhina
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

24 Kashirskoe Shosse, Moscow 115478



G. S. Batyrova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation

24 Kashirskoe Shosse, Moscow 115478



References

1. Soft Tissue and Bone Tumors. Ed. by WHO Classification of Tumours Editorial Boards. 5th edn. Lyon: IARC, 2020.

2. Dahlin D., Unni K.K. Chondrosarcoma (primary, secondary, dedifferentiated, and clear cell). Bone tumors: general aspects and data on 8,542 cases. 4th edn. Springfield, III: Thomas, 1986. Pp. 227–259.

3. Соловьев Ю.Н. Хрящеобразующие опухоли. Патолого-анатомическая диагностика опухолей человека. Руководство для врачей. Под ред. Н.А. Краевского, А.В. Смольянникова. М.: Медицина, 1993.

4. Murphey M.D., Walker E.A., Wilson A.J. et al. From the archives of the AFIP: imaging of primary chondrosarcoma: radiologicpathologic correlation. Radiographics 2003:23(5):1245–78. DOI: 10.1148/rg.235035134.

5. Bulycheva I.V., Fedorova A.V., Klein M.J., Soloviev Yu.N. Atlas of orthopedic pathology. Vol. 1. Cartilage-forming tumors. Moscow: ABC-press, 2021. 192 p. (In Russ.).

6. Bjornsson J., McLeod R.A., Unni K.K. et al. Primary chondrosarcoma of long bones and limb girdles. Cancer 1998;83(10):2105–19.

7. Eriksson A.I., Schiller A., Mankin H.J. The management of chondrosarcoma of bone. Clin Orthop Relat Res 1980;153:44–66.

8. Ishida T., Kikuchi F., Machinami R. Histological grading and morphometric analysis of cartilaginous tumours. Virchows Arch A Pathol Anat Histopathol 1991;418(2):149–55. DOI: 10.1007/BF01600290.

9. Meachim G. Histological grading of chondrosarcomata. J Bone Joint Surg Br 1979;61-B(4):393–4. DOI: 10.1302/0301-620X.61B4.500745.

10. Sanchez-Rodriguez V., Medina-Romero F., Gomez Rodriguez-Bethencourt M.A. et al. Value of the bone scintigraphy in multiple osteochondromatosis with sarcomatous degeneration. Rev Esp Med Nucl Imagen Mol 2012;31(5):270–4.

11. Bernard S.A., Murphey M.D., Flemming D.J., Kransdorf M.J. Improved differentiation of benign osteochondromas from secondary chondrosarcomas with standardized measurement of cartilage cap at CT and MR imaging. Radiology 2010;255(3):857–65. DOI: 10.1148/radiol.10082120.

12. Ahmed A.R., Tan T.S., Unni K.K. et al. Secondary chondrosarcoma in osteochondroma: report of 107 patients. Clin Orthop Relat Res 2003;411:193–206. DOI: 10.1097/01.blo.0000069888.31220.2b.

13. Aliyev M.D., Soloviev Yu.N., Kharatishvili T.K. et al. Chondrosarcoma of the bone. Moscow: INFRA-M, 2006. (In Russ.).

14. Gelderblom H., Hogendoorn P.C., Dijkstra S.D. et al. The clinical approach towards chondrosarcoma. Oncologist 2008;13(3):320–9. DOI: 10.1634/theoncologist.2007-0237.

15. Mirra J. Intramedullary cartilageand chondroid-producing tumors. In: Bone Tumors Clinical, Radiologic and Pathologic Correlations. Ed. by J.M. Mirra, R.H. Gold. Philadelphia: Lea & Febiger, 1989. Pp. 439–690.

16. Sofronov D.I., Sushentsov E.A., Musaev E.R. et al. Endoprosthetics of the pelvis with an individual 3D implant. Sarkomy kostej, myagkikh tkanej i opukholi kozhi = Bone and soft tissue sarcomas, tumors of the skin 2018;10(3):5–11. (In Russ.).

17. Gelderblom H., Hogendoorn P.C., Dijkstra S.D. et al. The clinical approach towards chondrosarcoma. Oncologist 2008;13(3):320–9. DOI: 10.1634/theoncologist.2007-0237.

18. Fiorenza F., Abudu A., Grimer R.J. et al. Risk factors for survival and local control in chondrosarcoma of bone. J Bone Joint Surg Br 2002;84(1):93–9. DOI: 10.1302/0301-620x.84b1.11942.

19. Unni K. Chondrosarcoma (primary, secondary, dedifferentiated, and clear cell). In: Dahlin’s bone tumors general aspects and data on 11,087 cases. Ed. by K. Unni. Philadelphia: Lippincot-Raven Publishers, 1996. Pp. 71–108.

20. Errani C., Tsukamoto S., Ciani G. et al. Risk factors for local recurrence from atypical cartilaginous tumour and enchondroma of the long bones. Eur J Orthop Surg Traumatol 2017;27(6):805–11. DOI: 10.1007/s00590-017-1970-4.

21. Brown M.T., Gikas P.D., Bhamra J.S. et al. How safe is curettage of low-grade cartilaginous neoplasms diagnosed by imaging with or without pre-operative needle biopsy? Bone Joint J 2014;96-B(8):1098–105. DOI: 10.1302/0301-620X.96B8.32056.

22. Angelini A., Guerra G., Mavrogenis A.F. et al. Clinical outcome of central conventional chondrosarcoma. J Surg Oncol 2012;106(8): 929–37. DOI: 10.1002/jso.23173.

23. Evans H.L., Ayala A.G., Romsdahl M.M. Prognostic factors in chondrosarcoma of bone: a clinicopathologic analysis with emphasis on histologic grading. Cancer 1977;40(2):818–83. DOI: 10.1002/1097-0142(197708)40:2 <818::aid-cncr2820400234>3.0.co;2-b.

24. Brien E.W., Mirra J.M., Kerr R. Benign and malignant cartilage tumors of bone and joint: their anatomic and theoretical basis with an emphasis on radiology, pathology and clinical biology. I. The intramedullary cartilage tumors. Skeletal Radiol 1997;26(6):325–53. DOI: 10.1007/s002560050246.

25. Kristensen I.B., Sunde L.M., Jensen O.M. Chondrosarcoma. Increasing grade of malignancy in local recurrence. Acta Pathol Microbiol Immunol Scand A 1986;94(2):73–7.

26. Duchman K.R., Lynch C.F., Buckwalter J.A., Miller B.J. Estimated cause-specific survival continues to improve over time in patients with chondrosarcoma. Clin Orthop Relat Res 2014;472(8):2516–25. DOI: 10.1007/s11999-014-3600-3.

27. Kobayashi H., Kotoura Y., Hosono M. et al. Diagnostic value of Tc-99m (V) DMSA for chondrogenic tumors with positive Tc-99m HMDP uptake on bone scintigraphy. Clin Nucl Med 1995;20(4):361–4. DOI: 10.1097/00003072-199504000-00015.

28. Subhawong T.K., Winn A., Shemesh S.S. et al. F-18 FDG PET differentiation of benign from malignant chondroid neoplasms: a systematic review of the literature. Skeletal Radiol 2017;46(9): 1233–9. DOI: 10.1007/s00256-017-2685-7.

29. De Beuckeleer L.H., De Schepper A.M., Ramon F. Magnetic resonance imaging of cartilaginous tumors: is it useful or necessary? Skeletal Radiol 1996;25(2): 137–41. DOI: 10.1007/s002560050050.

30. Kransdorf M.J., Murphey M.D. Imaging of soft-tissue musculoskeletal masses: fundamental concepts. Radiographics 2016;36(6):1931–48. DOI: 10.1148/rg.2016160084.

31. Федорова А.В., Кочергина Н.В., Булычева И.В. и др. Возможности магнитно-резонансной томографии с контрастированием в уточнении степени дифференцировки хондросаркомы: клиническое наблюдение. Бюллетень сибирской медицины 2018;17(3):235–41. Fedorova A.V., Kochergina N.V., Bulycheva I.V. et al. The possibilities of magnetic resonance imaging with contrast in clarifying the degree of differentiation of chondrosarcoma: clinical observation. Byulleten’ sibirskoj mediciny = Bulletin of Siberian Medicine 2018;17(3):235–41. (In Russ.). DOI: 10.20538/1682-0363-2018-3-235-241.

32. Verstraete K.L., Van der Woude H.J., Hogendoorn P.C. et al. Dynamic contrastenhanced MR imaging of musculoskeletal tumors: basic principles and clinical applications. J Magn Reson Imaging 1996;6(2):311–21. DOI: 10.1002/jmri.1880060210.

33. Dahlin D.C., Henderson E.D. Chondrosarcoma, a surgical and pathological problem; review of 212 cases. J Bone Joint Surg Am 1956;38-A(5): 1025–38.

34. Mirra J.M., Gold R., Downs J. et al. A new histologic approach to the differentiation of enchondroma and chondrosarcoma of the bones. A clinicopathologic analysis of 51 cases. Clin Orthop Relat Res 1985;201:214–37.

35. Konishi E., Nakashima Y., Mano M. et al. Primary central chondrosarcoma of long bone, limb girdle and trunk: Analysis of 174 cases by numerical scoring on histology. Pathol Int 2015;65(9):468–75. DOI: 10.1111/pin.12324.

36. Welkerling H., Dreyer T., Delling G. Morphological typing of chondrosarcoma: a study of 94 cases. Virchows Arch A Pathol Anat Histopathol 1991;418(5):419–25. DOI: 10.1007/BF01605928.

37. Kwee R.M., Kwee T.C. Diagnostic performance of MRI in detecting locally recurrent soft tissue sarcoma: systematic review and meta-analysis. Eur Radiol 2022;32(6):3915–30. DOI: 10.1007/s00330-021-08457-w.

38. Guermazi A., Roemer F.W. Compositional MRI assessment of cartilage: what is it and what is its potential for sports medicine? Br J Sports Med 2016;50(15):896–7. DOI: 10.1136/bjsports-2015-095146.

39. Varma D.G., Ayala A.G., Carrasco C.H. et al. Chondrosarcoma: MR imaging with pathologic correlation. Radiographics 1992;12(4):687–704. DOI: 10.1148/radiographics.12.4.1636034.

40. Righi A., Pacheco M., Cocchi S. et al. Secondary peripheral chondrosarcoma arising in solitary osteochondroma: variables influencing prognosis and survival. Orphanet J Rare Dis 2022;17(1):1–8. DOI: 10.1186/s13023-022-02210-2.

41. Musaev E.R., Sofronov D.I., Sushentsov E.A. et al. Secondary chondrosarcoma of the pelvis. Clinical example and literature review. Sarkomy kostej, myagkikh tkanej i opukholi kozhi = Bone and soft tissue sarcomas, tumors of the skin 2017;4:17–22. (In Russ.).


Review

For citations:


Fedorova A.V., Sushentsov E.A., Agaev D.K., Kochergina N.V., Bludov A.B., Shchipakhina Y.A., Batyrova G.S. Diagnostic and treatment of secondary chondrosarcoma of the femur with multiple recurrences. Case report. Bone and soft tissue sarcomas, tumors of the skin. 2022;14(2):52‑60. (In Russ.) https://doi.org/10.17650/2782-3687-2022-14-2-52-60

Views: 251


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2219-4614 (Print)
ISSN 2782-3687 (Online)