Molecular markers in diagnostics of bone tumors
Abstract
There has been tremendous progress in the last decade in understanding of the behavior and molecular pathogenesis of sarcomas, which may ultimately lead to more effective therapy and prognostification for these rare malignancies. Bone and soft tissue sarcomas are uncommon group of tumors, they are histologically, behaviorally, and genetically diverse, and their pathogenesis is poorly understood. The increasing role of molecular diagnostics is up to date, this knowledge relates to the potential role of newer targeted therapies. The importance of multidisciplinary care, integration of histologic, molecular, radiographic and clinical data in the management of bone sarcomas is difficult to overestimate.
About the Authors
I. V. Bulytcheva
FGBU N.N. Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
Y. N. Soloviov
FGBU N.N. Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
N. E. Kushlinskiy
FGBU N.N. Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
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Review
For citations:
Bulytcheva I.V., Soloviov Y.N., Kushlinskiy N.E. Molecular markers in diagnostics of bone tumors. Bone and soft tissue sarcomas, tumors of the skin. 2013;(3):73-78. (In Russ.)
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