The sterile deimmunized matrix for the replacement of extended defects in bone
Abstract
On the base of N.N. Blokhin Russian Cancer Research Center of RAMs had been designed the method of acquiring sterile deimmunized matrix from donor bone. This matrix can be used as a base for bioimplants for replacing bone defects. The aim of the research was the estimation of influence of the chemical treatment to the bone mechanical properties and the suppression of acute implant rejection. It was proved that the method provides sterilization and decreases immunogenicity of the matrix (absence of any degradation signs and absence of rejection reaction spreading during syngenic heterotopic transplantation in mice). After applying this method, we do not observe any signs of decreasing of mechanical properties (yield stress, Young's modulus, ultimate stress) in comparison with intact bone.
Keywords
матрикс,
кость,
деиммунизация,
прочность,
стерильность,
matrix,
bone,
deimmunization,
strength,
sterility
About the Authors
N. Yu. Anisimova
FGBU N.N. Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
A. N. Kopylov
FGBU N.N. Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
E. A. Kornyushenkov
FGBU N.N. Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
D. E. Mitrushkin
FGBU N.N. Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
A. V. Maximkin
National university of science and Technology «MISIS»
Russian Federation
Russian Federation
E. A. Sushenzov
FGBU N.N. Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
M. V. Kiselevsky
FGBU N.N. Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
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Review
For citations:
Anisimova N.Yu., Kopylov A.N., Kornyushenkov E.A., Mitrushkin D.E., Maximkin A.V., Sushenzov E.A., Kiselevsky M.V. The sterile deimmunized matrix for the replacement of extended defects in bone. Bone and soft tissue sarcomas, tumors of the skin. 2013;(2):49-54. (In Russ.)
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