Limb-sparing treatment results for spontaneous canine osteosarcoma patients with allogenic bone transplantation

Background. Canine osteosarcoma is a most common bone tumor in dogs, usually involving long tubular bones lesion. Limb-sparing treatment method allows to save extremity functionality and sufficiently improve quality of life in comparison with amputation. Objective. Analysis of survival rates and local results after limb-sparing treatment of canine osteosarcoma using bio-implantation (de-immunized allogenic bone populated with recipient stromal mesenchymal cell preparation). Materials and methods. Group of 25 dogs underwent a combined treatment including cisplatinum chemotherapy (60-70 mg/m² i/v infusion at 14-21 day intervals, up to 4 cycles) and wide segmental resection of the affected bone with a bio-implant defect replacement. Overall survival, progression-free survival and local recurrence frequency in the group were analyzed. Results. The median overall survival was 321 day, and median progression-free was 222 days. 4 cases (16.6%) of local relapse were recorded, 2 of which were confirmed by radiography and histological examination, and 2 other by radiography only. Conclusion. Efficiency of the canine appendicular osteosarcoma combined limb-sparing treatment is comparable with amputation practice results (according to scientific literature) while foregoing method is preferable due to higher life quality of patients.

bioimplantation, bone, limb-sparing surgery, osteosarcoma, dog

1. Mitchell KE, Boston SE, Kung M, Dry S, Straw RC, Ehrhart NP, Ryan SD. Outcomes of Limb-Sparing Surgery Using Two Generations of Metal Endoprosthesis in 45 Dogs With Distal Radial Osteosarcoma. A Veterinary Society of Surgical Oncology Retrospective Study. Vet Surg. 2016;45(1):36-43. DOI: 10.1111/vsu.12423. PMID: 26731595.

2. MacDonald TL, Schiller TD. Limb-sparing surgery using tantalum metal endoprosthesis in a dog with osteosarcoma of the distal radius. Can Vet J. 2010; 51(5):497-500. PMID: 20676291.

3. Jehn C, Farese J, Lewis D et al. Current treatment options for dogs with appendicular osteosarcoma. Vet Med. 2005;100:295-305.

4. Gassel A, Bilbrey S. Limb-sparing surgery for appendicular osteosarcoma in dogs. Vet Med. 2003;98:119-124.

5. Jehn C, Farese J, Lewis D et al. Current treatment options for dogs with appendicular osteosarcoma. Vet Med. 2005;100:295-305.

6. Morello E, Buracco P, Martano M et al. Bone allografts and adjuvant cisplatin for the treatment of canine appendicular osteosarcoma in 18 dogs. J Small Anim Pract. 2001;42(2):61-66. PMID: 11263699.

7. Lascelles BD, Dernell WS, Correa MT et al. Improved survival associated with postoperative wound infection in dogs treated with limb-salvage surgery for osteosarcoma. Ann Surg Oncol. 2005;12(12):1073-1083. DOI: 10.1245/ASO.2005.01.011. PMID: 16252138.

8. Szewczyk M, Lechowski R, Zabielska K. What do we know about canine osteosarcoma treatment? Review. Vet Res Commun. 2015;39(1):61-67.

9. Корнюшенков ЕА, Голуб ЛВ, Анисимова НЮ и соавт. Новые пути решения проблемы замещения дефектов при обширной резекции у животных с опухолями костей. Российский ветеринарный журнал. Мелкие домашние и дикие животные. 2013;3:12-16.

10. Liptak JM, Dernell WS, Ehrhart N et al. Cortical allograft and endoprosthesis for limb-sparing surgery in dogs with distal radial osteosarcoma: a prospective clinical comparison of two different limb-sparing techniques. Vet Surg. 2006;35(6):518-533. DOI: 10.1111/j.1532-950X.2006.00185.x. PMID: 16911152.

11. MacDonald TL, Schiller TD. Limb-sparing surgery using tantalum metal endoprosthesis in a dog with osteosarcoma of the distal radius. Can Vet J. 2010;51(5):497-500. PMID: 20676291.

12. Withrow SJ, Liptak JM, Straw RC et al. Biodegradable cisplatin polymer in limb-sparing surgery for canine osteosarcoma. Ann Surg Oncol. 2004;11(7):705-713. DOI: 10.1245/ ASO.2004.10.008. PMID: 15231525.

13. Анисимова НЮ, Копылов АН, Корнюшенков ЕА и соавт. Стерильный деиммунизированный матрикс для замещения расширенных дефектов костной ткани. Саркомы костей, мягких тканей и опухоли кожи. 2013;(2):49-54.