Prevalence and Clinical Significance of Merkel cell polyomavirus in Merkel cell carcinoma
Abstract
Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer that is often associated with Merkel cell polyomavirus (MCPyV) infection. MCPyV prevalence and its relationship with clinical features and prognosis in MCC remain unclear. The aim of the study was to investigate the frequency and pattern of the MCPyV expression in primary and metastatic tumors from patients with MCC and evaluate the role of MCPyV in prognosis of patients with MCC in russia.
About the Authors
K. V. Orlova
N.N Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
Moscow
V. V. Delektorskaya
N.N Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
Moscow
M. G. Yakubovskaya
N.N Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
Moscow
Y. V. Vishnevskaya
N.N Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
Moscow
T. T. Kondratieva
N.N Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
Moscow
N. F. Orel
N.N Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
Moscow
L. V. Demidov
N.N Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
Moscow
References
1. Schrama D., Peitsch W. et al. Merkel cell polyomavirus status is not associated with clinical course of Merkel cell carcinoma. J. Invest. Dermatol. 2011, v. 131, p. 1631-1638.
2. Albores-Saavedra J., Batich K, Chable-Montero F. Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study. J. Cutan. Pathol. 2010, v. 37 (1), p. 20-27.
3. Lunder E.J., Stern R.S. Merkel-cell carcinomas in patients treated with methoxsalen and ultraviolet A radiation. N. Engl. J. Med. 1998, v. 339, p. 1247-1248.
4. Houben R., Michel B., Vetter-Kauczok C.S. Absence of classical MAP kinase pathway signalling in Merkel cell carcinoma. J. Invest. Dermatol. 2006, v. 126, p. 1135-1142.
5. Turk T., Crncevic Z. et al. Spontaneous regression of Merkel cell carcinoma in a patient with chronic lymphocytic leukemia: a case report. Journal of Medical Case Reports. 2009, No. 3, p. 7270.
6. Gross L. Proc. Soc. Exp. Biol. Med. 1953, v. 83, p. 414. [PubMed: 13064287].
7. Feng H., Shuda M., Chang Y., Moore P. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Sience. 2008, v. 319, p. 1096-1100.
8. Киселев Ф.Л., Имянитов Е.Н., Киселева Н.П., Левина Е.С. Молекулярная онкология: от вирусной теории к лечению рака. M.: ГЕОС. 2013, с. 38-40.
9. Rodig S.J., Cheng J., Wardzala J. et al. Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus. J. Clin. Invest. 2012, v. 122, p. 4645-4653.
Review
For citations:
Orlova K.V., Delektorskaya V.V., Yakubovskaya M.G., Vishnevskaya Y.V., Kondratieva T.T., Orel N.F., Demidov L.V. Prevalence and Clinical Significance of Merkel cell polyomavirus in Merkel cell carcinoma. Bone and soft tissue sarcomas, tumors of the skin. 2014;(3-4):58-62. (In Russ.)
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