Notochordal tumors (chordoma). Differential diagnosis. Immunohistochemical markers
Abstract
Chordomas, low-grade chondrosarcomas, metastatic carcinomas share many histological features, generating at times, considerable diagnostic difficulty and, not infrequently, requiring immunohistochemical analysis for appropriate classification. In an effort to clarify the diagnosis and differentiation with other cartilaginous tumors, samples from 58 patients with sacrum chordoma were examined by immunohistochemistry with a panel of antibodies. The panel included antibodies to cytokeratin (CK), epithelial membrane antigen (EMA), D2-40, GFAP (glial fibrillary acidic protein), NSE (neuron-specific enolase), chromogranin, TTF-1 (thyroid transcription factor), PSA, CDX-2, mammaglobin. The conventional chordoma stained for CK (16/16) EMA (13/16), NSE (12/16) and was negative for chromogranin, GFAP. Specific markers were helpful in differential with metastatic carcinomas. Chordomas are difficult to excise because of their location and intimate relation to critical structures. Two cases of dedifferentiated chordoma were described.
About the Authors
I. V. Boulytcheva
N.N. Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
Moscow
Franco Bertoni
Casa di Cura Villa Erbosa University of Bologna
Italy
Italy
Patrizia Bacchini
Casa di Cura Villa Erbosa University of Bologna
Italy
Italy
E. R. Musaev
N.N. Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
Moscow
References
1. Mitchell A., Scheithauer B.W., Unni K.K. et al. Chordoma and chondroid neoplasms of the spheno-occiput. A immunohistochemical study of 41 cases with prognostic and nosologic implications. Cancer. 1993, v. 72, No. 10, p. 2943-2949.
2. Hoch B.L., Nielsen G.P., Liebsh N.G. et al. Base of skull Chordomas in children and adolescents; a clinicopathologic study of 73 cases. Am. J. Surg. Pathol. 2006, v. 30, No. 70, p. 811-818.
3. Kyriakos M., Totty W.G., Lenke L.G. Giant vertebral notochordal rest: a lesion distinct from chordoma: discussion of an evolving concept. Am. J. Surg. Pathol. 2003, v. 27, No. 3, p. 396-406.
4. Yamaguchi T., Suzuki S., Ishiiwa H. et al. Benign notochordal cell tumors: a comparative histological study of benign notochordal cell tumors, classic chordomas, and notochordal vestides of fetal intervertebral discs. Am. J. Surg. Pathol. 2004, v. 28, p. 756-761.
5. Almefty K., Pravdenkova S., Colli B.O. et al. Chordoma and chondrosarcoma: similar, but quite different, skull base tumors. Cancer. 2007, v. 110, No. 11, p. 2457-2467.
6. Fuchs B., Dickey I.D., Yaszemski M.J. et al. Operative management of sacral chordoma. J. Bone Joint Surg. Am. 2005, v. 87, No. 10, p. 2211-2216.
7. O’Hara B.J., Paetau A., Miettinen M. Keratin subsets and monoclonal antibody HBME-1 in chordoma: immunohistochemical differential diagnosis between tumors simulating chordoma. Hum. Pathol. 1998, v. 29, No. 2, p. 119-126.
8. Cho H.Y., Lee M., Takei H. et al. Immunohistochemical comparison of chordoma with chondrosarcoma, myxopapillary ependymoma, chordoid meningioma. Appl. Immunoch
Review
For citations:
Boulytcheva I.V., Bertoni F., Bacchini P., Musaev E.R. Notochordal tumors (chordoma). Differential diagnosis. Immunohistochemical markers. Bone and soft tissue sarcomas, tumors of the skin. 2015;(2):31-35. (In Russ.)
Views:
820
Email this article 
