Chemoperfusion as a method of choice in sarcomas treatment
Abstract
Increased incidence of melanoma and soft tissue sarcomas of the extremities is observed nowadays. High probability of developing locally advanced forms of melanoma and soft tissue sarcomas of extremities lead to the use of combined treatment methods is quite high. In the 21st century the possibility of isolated limb perfusion chemotherapy gives patients a high objective response to therapy without their systemic administration, improving quality of life through the limb salvage. This review describes currently used therapeutic agents, results of ongoing clinical trials and personal data.
About the Authors
G. I. GaftonRussian Federation
U. V. Semiletova
Russian Federation
K. U. Senchik
Russian Federation
A. M. Belyaev
Russian Federation
I. G. Gafton
Russian Federation
References
1. Курбатов Г.К. и соавт. Анализ лечения злокачественной меланомы кожи в отделении общей онкологии ГУЗ АКОД за период с 2007 по 2009 г. Достижения современной онкологии. Под ред. д-ра мед. наук проф. А.Ф. Лазарева. Барнаул, 2010.
2. Рязанцева А.А. и соавт. Молекулярно-биологические подходы к дифференциальной диагностике меланомы кожи. Архив патологии. Москва, «Медицина». 2009, т. 71, № 5.
3. Тришкин В.А. и соавт. Оценка эффективности комбинированного лечения больных первичными саркомами мягких тканей конечностей, подвергшихся сберегательным операциям. Вопросы онкологии. 2009, т. 55, № 6, с. 722-726.
4. Феденко А.А., Горбунова В.А. Лечение диссеминированных сарком мягких тканей. Состояние проблемы в России. Вопросы онкологии. 2009, т. 55, № 5, с. 644-648.
5. Чиссов В.И. и соавт. Злокачественные новообразования в России в 2007 году (Заболеваемость и смертность). М., 2009.
6. Alexander H.R. Jr., Butler C.C. Development of isolated hepatic perfusion via the operative and percutaneous techniques for patients with isolated and unresectable liver metastases. Cancer J. 2010, v. 16 (2), p. 132-141.
7. Koops H.S., Vaglini M., Suciu S. et al. Prophylactic isolated limb perfusion for localized, high-risk limb melanoma: results of a multicenter randomized Phase III trial. European organization for research and treatment of cancer malignant melanoma cooperative group protocol 18832, the world health organization melanoma program trial 15, and the north american perfusion group southwest oncology group-8593. J. Clin. Oncol. 1998, v. 16 (9), p. 2906-2912.
8. Balch C.M., Buzaid A.C., Soong S.J. et al. Final version of the American joint committee on cancer staging system for cutaneous melanoma. Journal of Clinical Oncology. 2001, v. 19, No. 16, p. 3635-3648.
9. Creech O. Jr., Krementz E.T, Ryan R.F. et al. Chemotherapy of cancer: regional perfusion utilizing extracorporeal circuit. Ann. Surg. 1958, v. 148, p. 616-632.
10. De Wilt J.H., Manusama E.R et al. Prerequisites for effective isolated limb perfusion using tumour necrosis factor alpha and melphalan in rats. Br. J. Cancer. 1999, v. 80 (1–2), p. 161-166.
11. Eggermont A.M., de Wilt J.H.W., ten Hagen T.L.M. Current uses of isolated limb perfusion in the clinic and a model system for new strategies. Lancet Oncol. 2003, v. 4, p. 429-437.
12. Flaherty K.T., Puzanov I., Kim K.B. et al. Inhibition of mutated, activated BRAF in metastatic melanoma. The New England Journal of Medicine. 2010, v. 363, No. 9, p. 809-819.
13. Hayes A.J. Isolated limb perfusion with melphalan and tumor necrosis factor alpha for advanced melanoma and soft-tissue sarcoma. Ann. Surg. Oncol. 2007, v. 14(1), p. 230-238.
14. Hodi F.S., O’Day S.J., McDermott D.F. et al. Improved survival with ipilimumab in patients with metastatic melanoma. The New England Journal of Medicine. 2010, v. 363, No. 8, p. 711-723.
15. Hoekstra H.J. The European approach to in-transit melanoma lesions. International Journal of Hyperthermia. 2008, v. 24, No. 3, p. 227-237.
16. Klaase J.M, Kroon B.B et al. Prognostic factors for tumor response and limb recurrence-free interval in patients with advanced melanoma of the limbs treated with regional isolated perfusion with melphalan. Surgery. 1994, v. 115, p. 39-45.
17. Klaase J.M., Kroon B.B.R. et al. Relation between calculated melphalan peak concentrations and toxicity in regional isolated perfusion for melanoma. Reg. Cancer Treat. 1992, v. 4, p. 309-312.
18. Klauser J.M., Lev-Chelouche D., Meller I. et al. Isolated limb perfusion in the treatment of advanced soft-tissue sarcomas. Musculoskeletal Cancer Surgery. 2001, p. 75-84.
19. Klopp C.T., Alford T.C. et al. Fractional intra-arterial cancer chemotherapy. Ann. Surg. 1950, v. 132, p. 811-832.
20. Liénard D., Eggermont A.M. et al. Isolated limb perfusion with tumour necrosis factor-alpha and melphalan with or without interferon-gamma for the treatment of in-transit melanoma metastases: a multicentre randomized phase II study. Melanoma Res. 1999, v. 9 (5), p. 491-502.
21. McDermott D.F. et al. Двойное слепое рандомизированное исследование II фазы комбинации сорафениба и дакарбазина у больных с распространенной меланомой: сообщение исследовательской группы 11715. Journal of Clinical Oncology, русское издание. 2008, т. 2, № 3, с. 176-183.
22. Minor D.R., Allen R.E. et al. A clinical and pharmacokinetic study of isolated limb perfusion with heat and melphalan for melanoma. Cancer. 1985, v. 55, p. 2638-2644.
23. Pollock R.E. The seminal role of Cancer in our under- standing of sarcoma. Cancer. 2008, v. 113 (7 Suppl.), p. 1969-1979.
24. Ryan R.F., Krementz E.T. et al. Selected perfusion of isolated viscera with chemotherapeutic agents an using an extracorporeal circuit. S.Forum. 1957, v. 8, p. 158-161.
25. Thompson J.F., Gianoutsos M.P. Isolated limb perfusion for melanoma: effectiveness and toxicity of cisplatin compared with that of melphalan and other drugs. World J. Surg. 1992, v. 16 (2), p. 227-233.
26. Wernberg J.A. et al. Isolated regional Therapy. The Chemotherapy Source Book, Perry M.C. 2008, p. 99-107.
Review
For citations:
Gafton G.I., Semiletova U.V., Senchik K.U., Belyaev A.M., Gafton I.G. Chemoperfusion as a method of choice in sarcomas treatment. Bone and soft tissue sarcomas, tumors of the skin. 2015;(4):42-47. (In Russ.)