Сartilaginous bone tumors and matix metalloproteinases 1, 2, 9
Abstract
The expression levels of MMP-1,-2,-9 has been investigated in 10 benign cartilaginous tumors (osteochondroma - 5, chondroma - 5) and 39 chondrosarcomas (classic central - 14, periosteal - 4, dedifferentiated - 7, secondary - 14). The matrix metalloproteinase expression was negative in all examined benign human cartilaginous bone tumors. Our study have shown significant positive expression of metalloproteinase in chondrosarcoma cells: MMP-1 in 84,6% of cases, MMP-2 in 73,7 % of cases, MMP-9 in 97,4% of cases with the expression levels from 10 to 60%. No correlation was found between MMP-1 levels and gender of the patient, size and grade of the tumor, but correlate with the age. Expression of MMP-1 was more prominent in central and dedifferentiated chondrosarcomas. The levels of MMP-1(+) are closely associated with 3 year free survival and 5 year overall survival rate. The MMP-1 expression suggested aggressive behavior of the tumor. MMP-2 expression in chondrosaromas did not reflect clinical features, histological grade and variations of the tumor, and did not show prognostic value. MMP-9 expression correlate with the grade and size of the tumor (T criteria). MMP-9 expression more than 40% highly correlate with poor prognosis, less than 40% express positive factor for the 3 year free survival. The size of the tumor T3 in combination with MMP-9 expression more than 40% was considered a risk factor for relapse within
About the Authors
И. Булычева
Отделение патологической анатомии Московской онкологической больницы № 62
Russian Federation
Russian Federation
Н. Кушлинский
Российский онкологический научный центр им. Н.Н. Блохина РАМН
Russian Federation
Russian Federation
Ю. Соловьев
Российский онкологический научный центр им. Н.Н. Блохина РАМН
Russian Federation
Russian Federation
Е. Тен
Российский онкологический научный центр им. Н.Н. Блохина РАМН
Russian Federation
Russian Federation
Е. Дворова
Российский онкологический научный центр им. Н.Н. Блохина РАМН
Russian Federation
Russian Federation
А. Махсон
Отделение патологической анатомии Московской онкологической больницы № 62
Russian Federation
Russian Federation
I. V. Boulytcheva
Pathology Department Moscow oncology hospital № 62
Russian Federation
Russian Federation
N. E. Kushlinsky
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
Yu. N. Soloviev
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
E. A. Ten
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
E. K. Dvorova
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
A. N. Makhson
Pathology Department Moscow oncology hospital № 62
Russian Federation
Russian Federation
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For citations:
, , , , , , Boulytcheva I.V., Kushlinsky N.E., Soloviev Yu.N., Ten E.A., Dvorova E.K., Makhson A.N. Сartilaginous bone tumors and matix metalloproteinases 1, 2, 9. Bone and soft tissue sarcomas, tumors of the skin. 2011;(1):44-49. (In Russ.)
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