Preview

Bone and soft tissue sarcomas, tumors of the skin

Advanced search

Primary mandibular tumors, treatment, reconstruction and prognosis

Abstract

Background. Morphologically both mandibular sarcomas and sarcomas of other origin are very similar, but have difference in there clinical manifestation. Surgery is a gold standard. After partial mandibular resection simultaneous reconstruction is used to improve functional and esthetic aspects. Materials and methods. 82 patients with primary mandibular sarcomas were observed in the Russia Cancer Research Center from I960 till 2008. Osteosarcoma was the most common histological subtype. Surgery alone is the standard of care. Combined chemoradiotherapy is rarely used for specific histological subtypes. Simultaneous reconstruction was made in 23 patients. Reconstructive plate was used in 8 patients. In 3 cases musculo-cutaneous transferred flap was used. Vasculorised bone grafts were transplanted inl5 cases. Results. 5 - year survival in surgery group was 48%. None of patients who received chemoradiotherapy reached 4 year survival checkpoint. Local recurrences were higher when 2 or more anatomic areas where involved. Conclusion. Surgery is still a golden standard of care. Histological subtype, tumor location, surgery technique are the main prognostic factors.

About the Authors

M. A. Kropotov
N.N. Blokhin Russian Cancer Research Center, Russian Academy ofMedical Sciences
Russian Federation


V. A. Sobolevskiy
N.N. Blokhin Russian Cancer Research Center, Russian Academy ofMedical Sciences
Russian Federation


References

1. Воробьев Ю.И. Мегавольтная лучевая терапия злокачественных новообразований верхней челюсти. Автореф. дисс. докт. мед. наук. М., 1972.

2. Колесов А.А. Новообразования лицевого скелета. М., «Медицина». 1969.

3. Процык В.С. Комбинированное лечение злокачественных опухолей верхней челюсти. Автореф. дисс. докт. мед. наук. Киев, 1984.

4. Goepfert Н., Raymond А.К., Spires J.R. et al. Osteosarcoma of the head and neck. The cancer bulletin. 1990, v. 42, No. 5, p. 347-354.

5. Langman A.W., Kaplan M.J., Mattay K. Ewing sarcoma of the mandible. Otolaringol head and neck surg. 1989, v. 100, No. 1, p. 74-77.

6. Mellor T.K., Worrall S.F. Quality of life following treatment for oral quamous cell carcinoma. J. of Craniomaxillofacial Surgery, 1996, v. 23, s. l,p.75.

7. Peters E., Cohen M., Altini M. et al. Rhabdomyosarcoma of the oral and paraoral region. «Cancer», 1989, v. 63, p. 963-966.

8. Rogers S.N., Hannah L., Lowe D. et al. Quality of life 5-10 years after Primary Surgery for oral and oro-pharyngeal cancer. J. of Craniomaxillofacial Surgery, 1999, v. 27, p.187-191.

9. Silveberg B., Banis J.C., Acland R.D. Mandibular reconstruction with microvascular bone transfer. Am. J. Surg., 1985, v. 150, p. 440-446.

10. Shockley W.W., Weisser M.C., Pillsbury H.C. Immediate mandibular replacement using reconstruction plates. 1991, v. 117, p. 745-749.


Review

For citations:


Kropotov M.A., Sobolevskiy V.A. Primary mandibular tumors, treatment, reconstruction and prognosis. Bone and soft tissue sarcomas, tumors of the skin. 2010;(2):9-21. (In Russ.)

Views: 151


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2219-4614 (Print)
ISSN 2782-3687 (Online)