Early diagnosis of skin melanoma in the samara region in 1995–2019 using multi-agent technology
https://doi.org/10.17650/2070-9781-2020-12-4-22-31
- Р Р‡.МессенРТвЂВВВВВВВВжер
- РћРТвЂВВВВВВВВнокласснРСвЂВВВВВВВВРєРСвЂВВВВВВВВ
- LiveJournal
- Telegram
- ВКонтакте
- РЎРєРѕРїРСвЂВВВВВВВВровать ссылку
Full Text:
Abstract
Melanoma of the skin (MS) is a tumor with a predictable course, when diagnosed at the pT1a stage, the patient has an almost 100 % chance of curing the disease. Diagnosis of MS is carried out mainly by doctors of primary contact, the accuracy of the diagnosis is low. In a large industrial region with more than three million people, a study was conducted that showed a significant increase in the number of cases. In this regard, a multi-agent technology for melanoma diagnostics was developed in the Samara region. From 2010 to 2019, an experiment was carried out to introduce a multi-agent system for early diagnosis of MS, the results were analyzed for the period of its use (2010– 2019) and in comparison with another period – 2000–2009.
The aim of the study is to assess the effectiveness of early diagnosis of MS in the period from 1995 to 2019 in the Samara region in connection with the introduction of multi-agent technology.
Materials and methods.A retrospective analysis of the quality of diagnostics was carried out using a multi-agent system, consisting of the author’s expert system based on artificial intelligence (patent for invention No 2018620399, 2018613016), and without its implementation for the periods from 2000–2009 and 2010–2019. The primary documentation was analyzed: form 7, 35, 025/u. The coefficients of reliability (t, p) of the proportion of stages I–II and “thin” skin melanoma, linear and polynomial trend approximations were calculated. The result of histological examination was used as a reference method.
Results.It was shown that the proportion of diagnosed MS at stages I–II significantly increased as a result of the introduction of a multi-agent system (t= 0.04113219, p<0.05), the proportion of “immature” MS did not give statistically significant changes (t= 0.07303817, p>0.05).
Conclusion.It was concluded that for effective diagnosis of MS at stages I–II, the use of multi-agent technology is sufficient, but for diagnosis at the pre-invasive stage it is ineffective and requires an increase in the number of trained expert doctors.
About the Authors
E. Yu. NeretinRussian Federation
50 Solnechnaya St., Samara 443031
227 Chapayevskaya St., Samara 443001
T. G. Zolotareva
Russian Federation
50 Solnechnaya St., Samara 443031
50 Solnechnaya St., Samara 443031
References
1. Schadendorf D., van Akkooi A.C.J., Berking C. et al. Melanoma. Lancet 2018;392(10151):971−84. https://doi.org/10.1016/S0140-6736(18)31559-9. PMID: 30238891
2. Quintanilla-Dieck M.J., Bichakjian C.K. Management of Early-Stage Melanoma. Facial Plast Surg Clin North Am 2019; 27(1):35−42. https://doi.org/10.1016/j.fsc.2018.08.003. PMID: 30420071.
3. Higgins H.W. 2 nd, Lee K.C., Galan A., Leffell D.J. Melanomain situ: Part I. Epidemiology, Screening, and Clinical Features. J Am Acad Dermatol 2015;73(2):181−90, quiz 191−2. https://doi.org/10.1016/j.jaad.2015.04.014. PMID: 26183967.
4. Corneli P., Zalaudek I., Magaton Rizzi G., di Meo N. Improving the Early Diagnosis of Early Nodular Melanoma: Can We Do Better? Expert Rev Anticancer Ther 2018;18(10):1007−12. https://doi.org/10.1080/14737140.2018.1507822. PMID: 30079779.
5. Dinnes J., Deeks J.J., Grainge M.J. et al. Visual Inspection for Diagnosing Cutaneous Melanoma in Adults. Cochrane Database Syst Rev 2018;12(12):CD013194. https://doi.org/10.1002/14651858.CD013194. PMID: 30521684.
6. Dinnes J., Deeks J.J., Chuchu N. et al. Dermoscopy, With and Without Visual Inspection, for Diagnosing Melanoma in Adults. Cochrane Database Syst Rev 2018;12(12):CD011902. https://doi.org/10.1002/14651858.CD011902.pub2. PMID: 30521682.
7. Tarhini A.A., Lorigan P., Leachman S. Operable Melanoma: Screening, Prognostication, and Adjuvant and Neoadjuvant Therapy. Am Soc Clin Oncol Educ Book 2017;37:651−60. https://doi.org/10.14694/EDBK_174930.
8. Ferris L.K., Saul M.I., Lin Y. et al. A Large Skin Cancer Screening Quality Initiative: Description and First-Year Outcomes. JAMA Oncol 2017;3(8):1112−15. https://doi.org/10.1001/jamaoncol.2016.6779.
9. Hartman R.I., Lin J.Y. Cutaneous Melanoma-A Review in Detection, Staging, and Management. Hematol Oncol Clin North Am 2019;33(1):25−38. https://doi.org/10.1016/j.hoc.2018.09.005.
10. Tracey E.H., Vij A. Updates in Melanoma. Dermatol Clin 2019;37(1):73−82. https://doi.org/10.1016/j.det.2018.08.003.
11. Ko D., Lipner S.R. Comment on: “The first 30 years of the American Academy of Dermatology skin cancer screening program: 1985−2014”. J Am Acad Dermatol 2019;80(1):e23. https://doi.org/10.1016/j.jaad.2018.08.056.
12. Prado G., D'Amore P., Tagliero A. et al. A cross-sectional study of trends in the stage of melanoma at diagnosis in the United States from 2001−2011. J Am Acad Dermatol 2016;75(5):1057−9. https://doi.org/10.1016/j.jaad.2016.07.030.
13. Moloney F.J., Guitera P., Coates E. et al. Detection of primary melanoma in individuals at extreme high risk: a prospective 5-year follow-up study. JAMA Dermatol 2014;150(8):819−27. https://doi.org/10.1001/jamadermatol.2014.514. PMID: 24964862.
14. Shellenberger R., Nabhan M., Kakaraparthi S. Melanoma Screening: A Plan for Improving Early Detection. Ann Med 2016;48(3):142−8. https://doi.org/10.3109/07853890.2016.1145795. PMID: 26911192.
15. Kaiser M., Schiller J., Schreckenberger C. The effectiveness of a population-based skin cancer screening program: evidence from Germany. Eur J Health Econ 2018;19(3):355−67 https://doi.org/10.1007/s10198-017-0888-4.
16. Stang A., Garbe C., Autier P., Jöckel K.H. The many unanswered questions related to the German skin cancer screening programme. Eur J Cancer 2016;64:83−8. https://doi.org/10.1016/j.ejca.2016.05.029.
17. Wernli K.J., Henrikson N.B., Morrison C.C. et al. Screening for Skin Cancer in Adults: An Updated Systematic Evidence Review for the U.S. Preventive Services Task Force [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2016 Jul. Report No.: 14-05210-EF-1. U.S. Preventive Services Task Force Evidence Syntheses, formerly Systematic Evidence Reviews.
18. Katalinic A., Eisemann N., Waldmann A. Skin Cancer Screening in Germany. Documenting Melanoma Incidence and Mortality From 2008 to 2013. Dtsch Arztebl Int 2015;112(38):629−34. https://doi.org/10.3238/arztebl.2015.0629.
19. Hübner J., Waldmann A., Eisemann N. et al. Association between risk factors and detection of cutaneous melanoma in the setting of a population-based skin cancer screening. Eur J Cancer Prev 2017;27(6):1. https://doi.org/10.1097/CEJ.0000000000000392.
20. Barr R.G. Foreword to the Second Set of WFUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography. Ultrasound Med Biol 2017; 43(1):1−3.
21. Waldmann A., Nolte S., Weinstock M.A. et al. Skin cancer screening participation and impact on melanoma incidence in Germany − an observational study on incidence trends in regions with and without population-based screening. Br J Cancer 2012;106(5):970−4. https://doi.org/10.1038/bjc.2012.22.
22. Hübner J., Eisemann N., Brunßen A., Katalinic A. [Skin cancer screening in Germany: review after ten years] [Article in German]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2018 Dec;61(12):1536-43. https://doi.org/10.1007/s00103-018-2836-6. PMID: 30411137.
23. Roncati L., Pusiol T., Piscioli F. Prognostic Predictors of Thin Melanoma in ClinicoPathological Practice. Acta Dermatovenerol Croat 2017;25(2):159−60. PMID: 28871933.
24. Klapperich M.E., Bowen G.M., Grossman D. Current Controversies in Early-Stage Melanoma: Questions on Management and Surveillance. J Am Acad Dermatol 2019;80(1):15−25. https://doi.org/10.1016/j.jaad.2018.03.054. PMID: 30553299.
25. Scott J.D., McKinley B.P., Bishop A., Trocha S.D. Treatment and Outcomes of Melanoma With a Breslow's Depth Greater Than or Equal to One Millimeter in a Regional Teaching Hospital. Am Surg 2005;71(3):198−201.
26. Gershenwald J., Scolyer R., Hess K. et al. Melanoma of the skin. In: AJCC Cancer Staging Manual 8th ed. edn. Edited by Amin M., Edge S., Greene F. et al. New York: Springer International Publishing; 2017. Pp. 563−85.
Review
For citations:
Neretin E.Yu., Zolotareva T.G. Early diagnosis of skin melanoma in the samara region in 1995–2019 using multi-agent technology. Bone and soft tissue sarcomas, tumors of the skin. 2020;12(4):22-31. (In Russ.) https://doi.org/10.17650/2070-9781-2020-12-4-22-31
ISSN 2782-3687 (Online)