Clinical efficacy and safety of isolated limb perfusion with hyperthermia. Comparative study in patients with limb melanoma

Abstract

Aim. Аssessment of the effectiveness of patients with melanoma limbs treatment using the isolated perfusion chemotherapy in the conditions of hyperthermia.
Methods. It performed the analysis of 41 patients with lower extremity of disseminated melanoma treatment results. Patients were divided into 2 groups: main group – 24 patients received treatment with an isolated regional perfusion (prI), melphalan (10 mg/ l volume of the lower limbs); comparison group – 17 patients are treated with conventional methods with the implementation of mutilation were used. When the prI used the original methodology for monitoring chemotherapy income levels in the systemic circulation.
Results. It was found that the application of the procedure of isolated regional perfusion for locally disseminated melanoma of the skin contributes to significant increase in survival of patients: the overall two-year survival rate was up to 91,7% compared to 53,8% with standard treatment. local toxicity associated with carrying out the isolated limb perfusion was regional, in most cases did not exceed grade I and II on the extent Wieberdink scale. no cases of systemic toxicity of grade I–II CTC scale were observed, confirming the satisfactory safety of this method in the treatment of cancer.
Conclusion. method of isolated regional limb perfusion is clinically effective and safe in the treatment of locally disseminated melanoma of the skinlimbs, its use can reduce the incidence of recurrence of the disease and avoid performing the amputation surgery.