Prognostic significance of the biological subtype for the choice of surgical treatment tactics for early breast cancer (Literature review)

Abstract

The purpose of this systematic review is to identify the dependence of the subtype of breast cancer and the risk of developing a local-regional recurrence after breast-conserving surgery and radical mastectomy. The main predictors in the development of relapse in breast cancer can be considered young age, the degree of tumor malignancy, the size of the tumor node, the presence of lymphovascular invasion or lymph node involvement and adverse tumor subtypes. At present, there is no single-valued data on the choice of surgical treatment tactics for various biological subtypes, however effective systemic therapy as well as radiotherapy reduces the frequency of local recurrences after performing breast-conserving surgery in unfavorable tumor subtypes and, according to the results of studies, the overall and disease-free survival is comparable, as in the case of mastectomy. Breast-conserving surgery can be performed in young patients with unfavorable tumor subtypes, provided all the possibilities of modern chemoradiotherapy are used.